Summary
The Luis lab focuses on the role of the bone marrow microenvironment in the regulation of blood stem cell function. Our goal is to decode the molecular crosstalk between stem cells and their niches, and define it's role in the maintenance of homeostasis and the development of haematological malignancies.
For more information visit our Lab Website.
haematopoietic stem cells lab
We welcome informal enquires about opportunities to work in our team. If you are interested in joining the lab please get in touch
Selected Publications
Journal Articles
Carrelha J, Meng Y, Kettyle LM, et al., 2018, Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells, Nature, Vol:554, ISSN:0028-0836, Pages:106-+
Beerman I, Luis TC, Singbrant S, et al., 2017, The evolving view of the hematopoietic stem cell niche, Experimental Hematology, Vol:50, ISSN:0301-472X, Pages:22-26
Luis TC, Luc S, Mizukami T, et al., 2016, Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors, Nature Immunology, Vol:17, ISSN:1529-2908, Pages:1424-1435
Luis TC, Tremblay CS, Manz MG, et al., 2016, Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?, Experimental Hematology, Vol:44, ISSN:0301-472X, Pages:908-912
Sanjuan-Pla A, Macaulay IC, Jensen CT, et al., 2013, Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy, Nature, Vol:502, ISSN:0028-0836, Pages:232-+
Luis TC, Naber BAE, Roozen PPC, et al., 2011, Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion, Cell Stem Cell, Vol:9, ISSN:1934-5909, Pages:345-356