Imperial College London
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Dr Tiago C. Luis

Faculty of Medicine, Department of Immunology and Inflammation

Sir Henry Dale Fellow
 
 
 
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Contact

 

t.luis Website

 
 
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Location

 

9N4bCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Duarte:2018:10.1182/blood-2017-06-788505,
author = {Duarte, S and Woll, PS and Buza-Vidas, N and Chin, DWL and Boukarabila, H and Luis, TC and Stenson, L and Bouriez-Jones, T and Ferry, H and Mead, AJ and Atkinson, D and Jin, S and Clark, S-A and Wu, B and Repapi, E and Gray, N and Taylor, S and Mutvei, AP and Tsoi, YL and Nerlov, C and Lendahl, U and Jacobsen, SEW},
doi = {10.1182/blood-2017-06-788505},
journal = {Blood},
pages = {1712--1719},
title = {Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis},
url = {http://dx.doi.org/10.1182/blood-2017-06-788505},
volume = {131},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Although an essential role for canonical Notch signaling in generation of hematopoietic stem cells in the embryo and in thymic T-cell development is well established, its role in adult bone marrow (BM) myelopoiesis remains unclear. Some studies, analyzing myeloid progenitors in adult mice with inhibited Notch signaling, implicated distinct roles of canonical Notch signaling in regulation of progenitors for the megakaryocyte, erythroid, and granulocyte-macrophage cell lineages. However, these studies might also have targeted other pathways. Therefore, we specifically deleted, in adult BM, the transcription factor recombination signal-binding protein J κ (Rbpj), through which canonical signaling from all Notch receptors converges. Notably, detailed progenitor staging established that canonical Notch signaling is fully dispensable for all investigated stages of megakaryocyte, erythroid, and myeloid progenitors in steady state unperturbed hematopoiesis, after competitive BM transplantation, and in stress-induced erythropoiesis. Moreover, expression of key regulators of these hematopoietic lineages and Notch target genes were unaffected by Rbpj deficiency in BM progenitor cells.
AU  - Duarte,S
AU  - Woll,PS
AU  - Buza-Vidas,N
AU  - Chin,DWL
AU  - Boukarabila,H
AU  - Luis,TC
AU  - Stenson,L
AU  - Bouriez-Jones,T
AU  - Ferry,H
AU  - Mead,AJ
AU  - Atkinson,D
AU  - Jin,S
AU  - Clark,S-A
AU  - Wu,B
AU  - Repapi,E
AU  - Gray,N
AU  - Taylor,S
AU  - Mutvei,AP
AU  - Tsoi,YL
AU  - Nerlov,C
AU  - Lendahl,U
AU  - Jacobsen,SEW
DO  - 10.1182/blood-2017-06-788505
EP  - 1719
PY  - 2018///
SN  - 0006-4971
SP  - 1712
TI  - Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis
T2  - Blood
UR  - http://dx.doi.org/10.1182/blood-2017-06-788505
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430688700014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://ashpublications.org/blood/article/131/15/1712/36842/Canonical-Notch-signaling-is-dispensable-for-adult
UR  - http://hdl.handle.net/10044/1/109515
VL  - 131
ER  -
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