Summary
Tony Magee is Emeritus Professor of Membrane Biology at the National Heart and Lung Institute, Imperial College London. He is a Fellow of the Royal Society of Biology.
Professor Magee trained in biochemistry and protein chemistry and began work on lipid modification of proteins as a post-doc in 1980. He continued to work in this field as an independent investigator at the MRC's NIMR (Mill Hill, 1983-2001) and Imperial College London (2001-2020).
Professor Magee is an established leader in the field of protein lipidation and has been invited to speak at many international conferences and organise several colloquia and conferences. He has made major contributions in protein prenylation (co-discovering the prenylation of Ras proteins), protein acylation (of Ras proteins and Src family kinases) and lipid rafts (identifying a key role in T cell receptor signaling).
His current interests are in the enzymes catalyzing acylation of secreted proteins (e.g. Hedgehog proteins) and their role in cancer, in the functional role of protein acylation e.g. in signalling, and in novel applications of advanced light microscopy imaging.
Professor Magee established the Facility for Imaging by Light Microscopy (FILM) in 2006 and was academic lead until 2019. FILM is a multiuser facility in the Sir Alexander Fleming Building at South Kensington and ICTEM at Hammersmith campuses, currently with 12 microscopes (confocals, multiphotons, widefields, TIRF, superresolution, high content) providing access to state-of-the-art fluorescence microscopy. FILM has a highly experienced manager (Dr. A. Bruckbauer) and two support staff. The current academic lead is Professor Cristina Lo Celso.
Professor Magee currently holds a Wellcome Trust grant. He was the Director of Postgraduate Studies for the NHLI (2009-2019) and a Deputy Director of the Imperial College Graduate School (2005-2020).
Publications
Journals
Ritzefeld M, Zhang L, Xiao Z, et al., 2024, Design, synthesis and evaluation of inhibitors of hedgehog acyltransferase, Journal of Medicinal Chemistry, Vol:67, ISSN:0022-2623, Pages:1061-1078
Coupland CE, Andrei SA, Ansell TB, et al., 2021, Structure, mechanism, and inhibition of Hedgehog acyltransferase, Molecular Cell, Vol:81, ISSN:1097-2765, Pages:5025-+
Coupland CE, Andrei SA, Ansell TB, et al., 2021, Structure and Mechanism of Hedgehog Acyl Transferase, Molecular Cell, ISSN:1097-2765
Lanyon-Hogg T, Ritzefeld M, Zhang L, et al., 2021, Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)., Angew Chem Weinheim Bergstr Ger, Vol:133, ISSN:0044-8249, Pages:13654-13659
Lanyon-Hogg T, Ritzefeld M, Zhang L, et al., 2021, Photochemical probe identification of the small-molecule binding site in a mammalian membrane-bound O-acyltransferase, Angewandte Chemie International Edition, Vol:60, ISSN:1433-7851, Pages:13542-13547