Publications
211 results found
Cox B, Hadjantonakis AK, Collins JE, et al., 2000, Cloning and expression throughout mouse development of <i>mfat1</i>, a homologue of the <i>Drosophila</i> tumour suppressor gene <i>fat</i>, DEVELOPMENTAL DYNAMICS, Vol: 217, Pages: 233-240, ISSN: 1058-8388
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- Citations: 38
Janes PW, Ley SC, Magee AI, et al., 2000, The role of lipid rafts in T cell antigen receptor (TCR) signalling, SEMINARS IN IMMUNOLOGY, Vol: 12, Pages: 23-34, ISSN: 1044-5323
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- Citations: 354
Small V, Caveman, Magee AI, et al., 2000, Data not shown or data not allowed? (multiple letters), Journal of Cell Science, Vol: 113, Pages: 363-364, ISSN: 0021-9533
Messent AJ, Blissett MJ, Smith GL, et al., 2000, Expression of a single fair of desmosomal glycoproteins readers the corneal epithelium unique amongst stratified epithelia, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 41, Pages: 8-15, ISSN: 0146-0404
North AJ, Bardsley WG, Hyam J, et al., 1999, Molecular map of the desmosomal plaque, JOURNAL OF CELL SCIENCE, Vol: 112, Pages: 4325-4336, ISSN: 0021-9533
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- Citations: 171
Honjo H, Uzzaman M, Takagishi Y, et al., 1999, Altered patterns of gap junction distribution and anisotropic conduction properties in rats with pressure overload-induced hypertrophied ventricle, CIRCULATION, Vol: 100, Pages: 559-559, ISSN: 0009-7322
Janes PW, Ley SC, Magee AI, 1999, Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor, JOURNAL OF CELL BIOLOGY, Vol: 147, Pages: 447-461, ISSN: 0021-9525
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- Citations: 689
Magee T, Marshall C, 1999, New insights into the interaction of Ras with the plasma membrane, CELL, Vol: 98, Pages: 9-12, ISSN: 0092-8674
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- Citations: 130
Rickman L, Simrak D, Stevens HP, et al., 1999, N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma, HUMAN MOLECULAR GENETICS, Vol: 8, Pages: 971-976, ISSN: 0964-6906
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- Citations: 174
Roberts GA, Burdett IDJ, Pidsley SC, et al., 1998, Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression, EUROPEAN JOURNAL OF CELL BIOLOGY, Vol: 76, Pages: 192-203, ISSN: 0171-9335
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- Citations: 16
Cox B, Hadjantonakis K, Magee A, 1998, Role of a novel fat-like cadherin in mouse development., Publisher: ACADEMIC PRESS INC, Pages: 201-201, ISSN: 0012-1606
Bañó MC, Jackson CS, Magee AI, 1998, Pseudo-enzymatic S-acylation of a myristoylated Yes protein tyrosine kinase peptide <i>in vitro</i> may reflect non-enzymatic S-acylation <i>in vivo</i>, BIOCHEMICAL JOURNAL, Vol: 330, Pages: 723-731, ISSN: 0264-6021
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- Citations: 60
Marcozzi C, Burdett IDJ, Buxton RS, et al., 1998, Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion, JOURNAL OF CELL SCIENCE, Vol: 111, Pages: 495-509, ISSN: 0021-9533
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- Citations: 107
Kabouridis PS, Magee AI, Ley SC, 1997, S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes, EMBO JOURNAL, Vol: 16, Pages: 4983-4998, ISSN: 0261-4189
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- Citations: 314
Zlatkine P, Mehul B, Magee AI, 1997, Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif, JOURNAL OF CELL SCIENCE, Vol: 110, Pages: 673-679, ISSN: 0021-9533
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- Citations: 125
Marsden MD, Collins JE, Greenwood MD, et al., 1997, Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2), GENE, Vol: 186, Pages: 237-247, ISSN: 0378-1119
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- Citations: 26
Zlatkine P, Magee AI, 1997, Chapter 4 lipid modifications of proteins and their relevance to protein targeting, Principles of Medical Biology, Vol: 7, Pages: 67-91, ISSN: 1569-2582
All of the diverse types of lipid modification of proteins discovered in recent years can contribute in varying degree to protein targeting within cells. Frequently, multiple lipid modifications on a single protein act in concert with one another, or with primary amino acid sequences, to specify membrane binding and intracellular targeting. Outstanding questions which must be addressed in the coming years are as follows: (i) What are the enzymes involved in lipid modification of proteins and how are they regulated? (ii) How do lipid moieties contribute to membrane binding and targeting; is this via lipid-lipid or lipid-protein interactions or both? (iii) Are there other as yet unidentified lipid modifications? These questions will require the full range of modem molecular cell biological and biochemical approaches for their answer. Copyright © 1997 by JAI Press Inc.
Angst BD, Khan LUR, Severs NJ, et al., 1997, Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium, CIRCULATION RESEARCH, Vol: 80, Pages: 88-94, ISSN: 0009-7330
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- Citations: 195
Galbiati F, Guzzi F, Magee AI, et al., 1996, Chemical inhibition of myristoylation of the G-protein G(i1)alpha by 2-hydroxymyristate does not interfere with its palmitoylation or membrane association - Evidence that palmitoylation, but not myristoylation, regulates membrane attachment, BIOCHEMICAL JOURNAL, Vol: 313, Pages: 717-720, ISSN: 0264-6021
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- Citations: 33
ROBERTS GA, PIDSLEY SC, MAGEE AI, et al., 1995, INHIBITION OF DESMOSOME FORMATION IN MDCK CELLS BY SYNTHESIS OF TYPE-2 DESMOCOLLIN ANTISENSE RNA, MOLECULAR BIOLOGY OF THE CELL, Vol: 6, Pages: 1111-1111, ISSN: 1059-1524
MCCALLUM JF, WISE A, GRASSIE MA, et al., 1995, THE ROLE OF PALMITOYLATION OF THE GUANINE-NUCLEOTIDE-BINDING PROTEIN G(11)ALPHA DEFINING INTERACTION WITH THE PLASMA-MEMBRANE, BIOCHEMICAL JOURNAL, Vol: 310, Pages: 1021-1027, ISSN: 0264-6021
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- Citations: 40
McCallum JF, Wise A, Grassie MA, et al., 1995, The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane., Biochem J, Vol: 310 ( Pt 3), Pages: 1021-1027, ISSN: 0264-6021
Mutations of Cys-9 to serine, Cys-10 to serine and a combination of both alterations were produced in a cDNA encoding murine G11 alpha to potentially interfere with the ability of the expressed polypeptides to act as substrates for post-translational palmitoylation. Each of these mutants and the wild-type protein were expressed in simian COS-1 cells. Mutation of either cysteine-9 or cysteine-10 decreased the degree of palmitoylation of the protein by some 80% compared with the wild-type, while the double mutant totally failed to incorporate [3H]palmitate. By contrast, in all transfections the endogenously expressed simian G11 alpha incorporated [3H]palmitate to similar levels. Particulate and cytoplasmic fractions from these cells were subjected to SDS/PAGE under conditions which allow resolution of primate and rodent forms of G11 alpha. Immunoblotting of these fractions demonstrated that in all cases the endogenously expressed simian G11 alpha was exclusively associated with the particulate fraction, as was the transfected and expressed wild-type murine G11 alpha. By contrast, each of the mutated forms of murine G11 alpha displayed a distribution in which approx. 70% of the expressed protein was present in the particulate fraction and 30% in the supernatant. To examine the conformation of the particulate expressed forms of murine G11 alpha, these fractions were treated with various concentrations of sodium cholate and immunoblots were subsequently performed on the solubilized and remaining particulate proteins. Whereas essentially all of the endogenous simian G11 alpha was solubilized by treatment with 1% (w/v) sodium cholate and some 50% with 0.32% cholate, expressed wild-type murine G11 alpha was more recalcitrant to solubilization. However, that fraction of wild-type murine G11 alpha which was solubilized behaved identically to the endogenous simian G11 alpha on Superose-12 gel-exclusion chromatography. The particulate fraction of the C9S/C10S double mutant of m
MILLIGAN G, GRASSIE MA, WISE A, et al., 1995, G-PROTEIN PALMITOYLATION - REGULATION AND FUNCTIONAL-SIGNIFICANCE, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 23, Pages: 583-587, ISSN: 0300-5127
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- Citations: 21
JACKSON CS, ZLATKINE P, BANO C, et al., 1995, DYNAMIC PROTEIN ACYLATION AND THE REGULATION OF LOCALIZATION AND FUNCTION OF SIGNAL-TRANSDUCING PROTEINS, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 23, Pages: 568-571, ISSN: 0300-5127
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- Citations: 21
MILLIGAN G, PARENTI M, MAGEE AI, 1995, THE DYNAMIC ROLE OF PALMITOYLATION IN SIGNAL-TRANSDUCTION (VOL 20, PG 181, 1995), TRENDS IN BIOCHEMICAL SCIENCES, Vol: 20, Pages: 256-256, ISSN: 0968-0004
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- Citations: 1
Milligan G, Parenti M, Magee AI, 1995, The dynamic role of palmitoylation in signal transduction., Trends Biochem Sci, Vol: 20, Pages: 181-187, ISSN: 0968-0004
Guanine nucleotide binding protein (G protein)-linked receptors, the alpha-subunits of heterotrimeric G proteins and members of the Src family of nonreceptor tyrosine kinases are among many polypeptides that are posttranslationally modified by the addition of palmitate, a long-chain fatty acid. Attachment of palmitate to these proteins is dynamic and may be regulated by their activation. The presence of palmitate appears to play a key role in the membrane localization of either the entire polypeptide or parts of it, and may regulate the interactions of these polypeptides with other proteins.
MILLIGAN G, PARENTI M, MAGEE AI, 1995, THE DYNAMIC ROLE OF PALMITOYLATION IN SIGNAL-TRANSDUCTION, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 20, Pages: 181-186, ISSN: 0968-0004
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- Citations: 289
MAGEE AI, 1995, CELL-ADHESION MOLECULES AND INTRACELLULAR SIGNALING - FROM FLY TO MAN, CELLULAR SIGNALLING, Vol: 7, Pages: 165-170, ISSN: 0898-6568
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- Citations: 6
Soto-Cruz I, Magee AI, 1995, Effect of synthetic peptides representing the hypervariable region of p21ras on Xenopus laevis oocyte maturation., Biochem J, Vol: 306 ( Pt 1), Pages: 11-14, ISSN: 0264-6021
The carboxy-terminal hypervariable regions of p21ras proteins have been highly conserved throughout evolution but no function has been assigned to them yet. This region has been suggested as a possible candidate for receptor recognition. We have tested the possibility of this region being involved in p21ras biological function. Synthetic peptides corresponding to the hypervariable domains of p21N-ras and p21K(B)-ras were microinjected into Xenopus oocytes to assess their effect on oocyte maturation. The K(B)-ras peptide inhibited insulin-dependent but not progesterone-dependent maturation, in contrast with the N-ras peptide which did not inhibit maturation significantly. A control peptide, with the same amino acid composition as the K(B)-ras peptide but with a scrambled sequence, and poly(D,L-lysine) were inactive. Pentalysine had partial activity which may be due to its mimicking the lysine-rich stretch of the K(B)-ras sequence. The data support the hypothesis that the K(B)-ras gene product specifically is involved in transducing the insulin and/or insulin-like growth factor 1 signal.
SOTOCRUZ I, MAGEE AI, 1995, EFFECT OF SYNTHETIC PEPTIDES REPRESENTING THE HYPERVARIABLE REGION OF P21(RAS) ON XENOPUS-LAEVIS OOCYTE MATURATION, BIOCHEMICAL JOURNAL, Vol: 306, Pages: 11-14, ISSN: 0264-6021
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- Citations: 3
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