Imperial College London
Alternate

Professor Toby Maher

Faculty of Medicine, National Heart & Lung Institute

Professor of Interstitial Lung Disease
 
 
 
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Contact

 

+44 (0)20 7594 2151t.maher

 
 
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Assistant

 

Ms Georgina Moss +44 (0)20 7594 2151

 
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Location

 

364Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Byrne:2020:10.1084/jem.20191236,
author = {Byrne, A and powell, J and O'Sullivan, B and Ogger, P and Hoffland, A and Cook, J and Bonner, K and Hewitt, R and Simone, W and Ghai, P and Walker, S and Lukowski, S and Molyneaux, P and Saglani, S and Chambers, D and Maher, T and Lloyd, C},
doi = {10.1084/jem.20191236},
journal = {Journal of Experimental Medicine},
pages = {1--9},
title = {Dynamics of human monocytes and airway macrophages during healthy aging and post-transplant},
url = {http://dx.doi.org/10.1084/jem.20191236},
volume = {217},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The ontogeny of airway macrophages (AMs) in human lung and their contribution to disease are poorly mapped out. In mice, aging is associated with an increasing proportion of peripherally, as opposed to perinatally derived AMs. We sought to understand AM ontogeny in human lung during healthy aging and after transplant. We characterized monocyte/macrophage populations from the peripheral blood and airways of healthy volunteers across infancy/childhood (2–12 yr), maturity (20–50 yr), and older adulthood (>50 yr). Single-cell RNA sequencing (scRNA-seq) was performed on airway inflammatory cells isolated from sex-mismatched lung transplant recipients. During healthy aging, the proportions of blood and bronchoalveolar lavage (BAL) classical monocytes peak in adulthood and decline in older adults. scRNA-seq of BAL cells from lung transplant recipients indicates that after transplant, the majority of AMs are recipient derived. These data show that during aging, the peripheral monocyte phenotype is consistent with that found in the airways and, furthermore, that the majority of human AMs after transplant are derived from circulating monocytes.
AU  - Byrne,A
AU  - powell,J
AU  - O'Sullivan,B
AU  - Ogger,P
AU  - Hoffland,A
AU  - Cook,J
AU  - Bonner,K
AU  - Hewitt,R
AU  - Simone,W
AU  - Ghai,P
AU  - Walker,S
AU  - Lukowski,S
AU  - Molyneaux,P
AU  - Saglani,S
AU  - Chambers,D
AU  - Maher,T
AU  - Lloyd,C
DO  - 10.1084/jem.20191236
EP  - 9
PY  - 2020///
SN  - 0022-1007
SP  - 1
TI  - Dynamics of human monocytes and airway macrophages during healthy aging and post-transplant
T2  - Journal of Experimental Medicine
UR  - http://dx.doi.org/10.1084/jem.20191236
UR  - https://rupress.org/jem/article/doi/10.1084/jem.20191236/133575/Dynamics-of-human-monocytes-and-airway-macrophages
UR  - http://hdl.handle.net/10044/1/75303
VL  - 217
ER  -
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