Imperial College London
Alternate

Professor Toby Maher

Faculty of Medicine, National Heart & Lung Institute

Professor of Interstitial Lung Disease
 
 
 
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Contact

 

+44 (0)20 7594 2151t.maher

 
 
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Assistant

 

Ms Georgina Moss +44 (0)20 7594 2151

 
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Location

 

364Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Leeming:2021:10.1186/s12931-020-01590-y,
author = {Leeming, DJ and Genovese, F and Sand, JMB and Rasmussen, DGK and Christiansen, C and Jenkins, G and Maher, TM and Vestbo, J and Karsdal, MA},
doi = {10.1186/s12931-020-01590-y},
journal = {Respiratory Research},
pages = {1--7},
title = {Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis},
url = {http://dx.doi.org/10.1186/s12931-020-01590-y},
volume = {22},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory Syndrome (SARS) survivor's consequent to SARS-Cov-2 infection. Thus there is an urgent medical need for identification of readily available biomarkers that in patients with SARS-Cov-2 infection are able to; (1) identify patients in most need of medical care prior to admittance to an intensive care unit (ICU), and; (2) identify patients post-infection at risk of developing persistent fibrosis of lungs with subsequent impaired quality of life and increased morbidity and mortality. An intense amount of research have focused on wound healing and Extracellular Matrix (ECM) remodelling of the lungs related to lung function decline in pulmonary fibrosis (PF). A range of non-invasive serological biomarkers, reflecting tissue remodelling, and fibrosis have been shown to predict risk of acute exacerbations, lung function decline and mortality in PF and other interstitial lung diseases (Sand et al. in Respir Res 19:82, 2018). We suggest that lessons learned from such PF studies of the pathological processes leading to lung function decline could be used to better identify patients infected with SARS-Co-V2 at most risk of acute deterioration or persistent fibrotic damage of the lung and could consequently be used to guide treatment decisions.
AU  - Leeming,DJ
AU  - Genovese,F
AU  - Sand,JMB
AU  - Rasmussen,DGK
AU  - Christiansen,C
AU  - Jenkins,G
AU  - Maher,TM
AU  - Vestbo,J
AU  - Karsdal,MA
DO  - 10.1186/s12931-020-01590-y
EP  - 7
PY  - 2021///
SN  - 1465-9921
SP  - 1
TI  - Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis
T2  - Respiratory Research
UR  - http://dx.doi.org/10.1186/s12931-020-01590-y
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33546680
UR  - https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01590-y
UR  - http://hdl.handle.net/10044/1/86043
VL  - 22
ER  -
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