Dr Tom McKinnon is a Senior Lecturer in the Department of Immunology and Inflammation, specifically working in the field of thrombosis and haemostasis in collaboration with Professor Mike Laffan.
Tom graduated in 2003 with a first class degree in Biomedical Science and was awarded an Institute of Biomedical Science Presidents prize for outstanding achievement. He then obtained his PhD in 2007 at Imperial College under Professor Mike Laffan examining the role of glycosylation on the structure and function of Von Willebrand Factor. He continued this work as a post-doctoral research associate funded by the BHF, then in 2011 was awarded a prestigious BHF intermediate basic science fellowship to investigate the functional role of the C-terminal domains of Von Willebrand Factor and was appointed as a senior lecturer in June 2019.
The major focus of his research is the structure and function of Von Willebrand Factor and the bleeding disorder Von Willebrands disease. He is also focused on how VWF and its interaction with various binding partners may be exploited as anti-thrombotic targets. In collaboration with Apollo Therapeutics Tom is currently developing novel strategies to safely inhibit VWF function. In addition, he is involved in the development of shear-based assays for the analysis of blood coagulation and endothelial cell function under physiological flow conditions and is working on producing low cost microfluidic systems.
Tom is co-course director for MSc Molecular Medicine where he has promoted the use of innovative and interactive teaching and assessment methods to enhance the student experience. In addition, he is module 3 lead for the Haematology BSc and teaches on several other MSc pathways. Tom also supports various outreach programmes to encourage students from disadvantaged backgrounds to aim for careers in science and medicine.
et al., 2021, Blocking von Willebrand factor free thiols inhibits binding to collagen under high and pathological shear stress, Journal of Thrombosis and Haemostasis, Vol:19, ISSN:1538-7836, Pages:358-369
et al., 2021, SARS-CoV-2 antibody point-of-care testing in dialysis and kidney transplant patients with COVID-19., Kidney Medicine, Vol:3, ISSN:2590-0595, Pages:54-59.e1
et al., 2019, The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing, Blood, Vol:133, ISSN:0006-4971, Pages:2559-2569
et al., 2019, Evaluation of von Willebrand factor concentrates by platelet adhesion to collagen using an in vitro flow assay, Research and Practice in Thrombosis and Haemostasis, Vol:3, ISSN:2475-0379, Pages:126-135
et al., 2019, Gene therapy for thrombotic thrombocytopaenic purpura, Annual Conference of the British Society for Gene and Cell Therapy, Mary Ann Liebert, Pages:A14-A14, ISSN:1043-0342