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BibTex format

@article{Barringer:2019:biohorizons/hzy013,
author = {Barringer, R},
doi = {biohorizons/hzy013},
journal = {Bioscience Horizons},
pages = {1--12},
title = {Illuminating the secrets of crystals: microcrystal electron diffraction in structural biology},
url = {http://dx.doi.org/10.1093/biohorizons/hzy013},
volume = {11},
year = {2019}
}

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TY  - JOUR
AB  - X-ray crystallography (XRC) has visualised biological macromolecules in exquisite detail for over 50 years, relying on a combination of mathematical principles to offer insight into atomic structures. Crystals can diffract various elec-tromagnetic waves aside from the conventional X-ray, offering an alternative approach to crystallographic structural analysis. Microcrystal Electron Diffraction (MicroED) illuminates crystals with electron waves instead of X-rays. Two specialised groups have demonstrated that MicroED can give high resolution (often atomic) data, and now appears to be developing into a powerful alternative method to XRC or electron microscopy of macromolecules. How Mi-croED compares to XRC will be key to assessing it as a stand-alone crystallographic technique. This review presents a critical analysis of MicroED, with comments on theoretical and practical aspects and suggestions of further work and development.
AU  - Barringer,R
DO  - biohorizons/hzy013
EP  - 12
PY  - 2019///
SN  - 1754-7431
SP  - 1
TI  - Illuminating the secrets of crystals: microcrystal electron diffraction in structural biology
T2  - Bioscience Horizons
UR  - http://dx.doi.org/10.1093/biohorizons/hzy013
UR  - https://academic.oup.com/biohorizons/article/doi/10.1093/biohorizons/hzy013/5256436
UR  - http://hdl.handle.net/10044/1/66521
VL  - 11
ER  -

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