DrTonyNolan

Faculty of Natural Sciences, Department of Life Sciences

Honorary Senior Lecturer

Contact

t.nolan

Assistant

Mrs Lucy Collyns +44 (0)20 7594 5395

Location

Sir Alexander Fleming BuildingSouth Kensington Campus

Summary

I am a molecular biologist trying to manipulate the biology of the mosquitoes in ways that can interfere with their ability to transmit disease. I work mostly on the mosquito Anopheles gambiae, the main vector of the most severe form of human malaria in Africa. I am applying this work in the fields of genetic control, such as gene drive, and in understanding the genetics of insecticide resistance.

Since January 2019 I have taken up a position at group leader at the Liverpool School of Tropical Medicine but I will continue to hold an honorary appointment at Imperial to maintain some of my research and teaching interests there.

Selected Publications

Journal Articles

Bernardini F, Kriezis A, Galizi R, et al.Bernardini F, Kriezis A, Galizi R, Nolan T, Crisanti A close, 2019, Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis, Scientific Reports, Vol:9, ISSN:2045-2322

Kyrou K, Hammond AM, Galizi R, et al.Kyrou K, Hammond AM, Galizi R, Kranjc N, Burt A, Beaghton AK, Nolan T, Crisanti A close, 2018, A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes, Nature Biotechnology, Vol:36, ISSN:1087-0156, Pages:1062-1066

Hammond AM, Kyrou K, Bruttini M, et al.Hammond AM, Kyrou K, Bruttini M, North A, Galizi R, Karlsson X, Kranjc N, Carpi FM, D'Aurizio R, Crisanti A, Nolan T close, 2017, The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito, PLOS Genetics, Vol:13, ISSN:1553-7390

Bernardini F, Galizi R, Wunderlich M, et al.Bernardini F, Galizi R, Wunderlich M, Taxiarchi C, Kranjc N, Kyrou K, Hammond A, Nolan T, Lawniczak MNK, Papathanos PA, Crisanti A, Windbichler N close, 2017, Cross-Species Y Chromosome Function Between Malaria Vectors of the Anopheles gambiae Species Complex., Genetics, ISSN:0016-6731

Hammond A, Kyrou K, Bruttini M, et al.Hammond A, Kyrou K, Bruttini M, North A, Galizi R, Karlsson X, Carpi F, D’Aurizio R, Crisanti A, Nolan T close, 2017, The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito, PLOS Genetics, ISSN:1553-7390

NOLAN T, CRISANTI A, 2017, Using gene drives to limit the spread of malaria, Scientist, Vol:31, ISSN:0890-3670

Beaghton A, Hammond A, Nolan T, et al.Beaghton A, Hammond A, Nolan T, Crisanti A, Godfray HCJ, Burt A close, 2017, Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing, Genetics, Vol:205, Pages:1587-1596

Open Access Link

Nolan T, Crisanti A, 2016, DRIVING OUT MALARIA, Scientist, Vol:31, Pages:24-31

Hammond A, Galizi R, Kyrou K, et al.Hammond A, Galizi R, Kyrou K, Simoni A, Siniscalchi C, Katsanos D, Gribble M, Baker D, Marois E, Russell S, Burt A, Windbichler N, Crisanti A, Nolan T close, 2016, A CRISPR-Cas9 gene drive system-targeting female reproduction in the malaria mosquito vector Anopheles gambiae, Nature Biotechnology, Vol:34, ISSN:1087-0156, Pages:78-83

Castellano L, Rizzi E, Krell J, et al.Castellano L, Rizzi E, Krell J, Di Cristina M, Galizi R, Mori A, Tam J, De Bellis G, Stebbing J, Crisanti A, Nolan T close, 2015, The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs, Bmc Genomics, Vol:16

Open Access Link

Neafsey DE, Waterhouse RM, Abai MR, et al.Neafsey DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA, Allen JE, Amon J, Arca B, Arensburger P, Artemov G, Assour LA, Basseri H, Berlin A, Birren BW, Blandin SA, Brockman AI, Burkot TR, Burt A, Chan CS, Chauve C, Chiu JC, Christensen M, Costantini C, Davidson VLM, Deligianni E, Dottorini T, Dritsou V, Gabriel SB, Guelbeogo WM, Hall AB, Han MV, Hlaing T, Hughes DST, Jenkins AM, Jiang X, Jungreis I, Kakani EG, Kamali M, Kemppainen P, Kennedy RC, Kirmitzoglou IK, Koekemoer LL, Laban N, Langridge N, Lawniczak MKN, Lirakis M, Lobo NF, Lowy E, MacCallum RM, Mao C, Maslen G, Mbogo C, McCarthy J, Michel K, Mitchell SN, Moore W, Murphy KA, Naumenko AN, Nolan T, Novoa EM, O Loughlin S, Oringanje C, Oshaghi MA, Pakpour N, Papathanos PA, Peery AN, Povelones M, Prakash A, Price DP, Rajaraman A, Reimer LJ, Rinker DC, Rokas A, Russell TL, Sagnon NF, Sharakhova MV, Shea T, Simao FA, Simard F, Slotman MA, Somboon P, Stegniy V, Struchiner CJ, Thomas GWC, Tojo M, Topalis P, Tubio JMC, Unger MF, Vontas J, Walton C, Wilding CS, Willis JH, Wu Y-C, Yan G, Zdobnov EM, Zhou X, Catteruccia F, Christophides GK, Collins FH, Cornman RS, Crisanti A, Donnelly MJ, Emrich SJ, Fontaine MC, Gelbart W, Hahn MW, Hansen IA, Howell PI, Kafatos FC, Kellis M, Lawson D, Louis C, Luckhart S, Muskavitch MAT, Ribeiro JM, Riehle MA, Sharakhov IV, Tu Z, Zwiebel LJ, Besansky NJ close, 2015, Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes, Science, Vol:347

Volohonsky G, Terenzi O, Soichot J, et al.Volohonsky G, Terenzi O, Soichot J, Naujoks DA, Nolan T, Windbichler N, Kapps D, Smidler AL, Vittu A, Costa G, Steinert S, Levashina EA, Blandin SA, Marois E close, 2015, Tools for Anopheles gambiae Transgenesis, G3-genes Genomes Genetics, Vol:5, Pages:1151-1163

Open Access Link

Fuchs S, Behrends V, Bundy JG, et al.Fuchs S, Behrends V, Bundy JG, Crisanti A, Nolan T close, 2014, Phenylalanine Metabolism Regulates Reproduction and Parasite Melanization in the Malaria Mosquito, Plos One, Vol:9

Open Access Link

Fuchs S, Rende E, Crisanti A, et al.Fuchs S, Rende E, Crisanti A, Nolan T close, 2014, Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival, Scientific Reports, Vol:4

Open Access Link

Catteruccia F, Nolan T, Loukeris TG, et al.Catteruccia F, Nolan T, Loukeris TG, Blass C, Savakis C, Kafatos FC, Crisanti A close, 2000, Stable germline transformation of the malaria mosquito Anopheles stephensi, Nature, Vol:405, Pages:959-962

More Publications