Imperial College London

DrTonyNolan

Faculty of Natural SciencesDepartment of Life Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

t.nolan

 
 
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Assistant

 

Mrs Lucy Collyns +44 (0)20 7594 5395

 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

AREAS OF INTEREST

  • Oogenesis in the mosquito
  • Chorion formation in the mosquito egg
  • Sex determination mechanisms in the mosquito
  • Gene drive to modify insect vector populations
  • Sex chromosome biology in mosquitoes
  • The role of non-coding RNAs in the mosquito germline
  • CRISPR as a genome editing tool in the mosquito
  • Experimental evolution in the mosquito to rapidly select  traits
  • The genetics of insecticide resistance
  • Developing new functional genetics tool for different mosquito species

RELEVANT PUBLICATIONS

show research

A Beaghton, A Hammond, T Nolan, A Crisanti, HCJ Godfray, A Burt. Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing. Genetics 2017, 205 (4), 1587-1596

AB Hall, PA Papathanos, A Sharma, C Cheng, OS Akbari, L Assour, ...T Nolan… IV Sharakhov, ZJ Tu, NJ Besansky Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes PNAS 2016, 201525164

Roberto Galizi, Andrew Hammond, Kyros Kyrou, Chrysanthi Taxiarchi, Federica Bernardini, Samantha M O’Loughlin, Philippos-Aris Papathanos, Tony Nolan, Nikolai Windbichler, Andrea Crisanti A CRISPR-Cas9 sex-ratio distortion system for genetic control Scientific Reports 2016 Vol 6

Hammond A, Galizi R, Kyrou K, Simoni A, Siniscalchi C, Katsanos D, Gribble M, Baker D, Marois E, Russell S, Burt A, Windbichler N, Crisanti A, Nolan T. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature Biotechnology 2016, 34, 78–83 

L Castellano, E Rizzi, J Krell, M Di Cristina, R Galizi, A Mori, J Tam, G DeBellis, J Stebbing, A Crisanti, T Nolan.The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs BMC genomics 2015 Feb 19 16 (1), 100

DE Neafsey, RM Waterhouse, MR Abai, SS Aganezov, MA Alekseyev et al. Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes Science 2015 Jan 2 347 (6217), 1258522

G Volohonsky, O Terenzi, J Soichot, DA Naujoks, T Nolan…S Blandin, E Marois. Tools for Anopheles gambiae transgenesis G3: Genes| Genomes| Genetics 5 (6), 1151-1163

 S Fuchs, E Rende, A Crisanti, T Nolan. Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival Scientific Reports Jul 2;4:5526 

SB Thyme, SJS Boissel, SA Quadri, T Nolan, D Baker et al... Reprogramming homing endonuclease specificity through computational design and directed evolution Nucleic Acids Research 2014 42 (4), 2564-2576

Baker DA, Nolan T, Fischer B, Pinder A, Crisanti A, Russell S. A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae. BMC Genomics. 2011 Jun 7;12:296.

Nolan T, Papathanos P, Windbichler N, Magnusson K, Benton J, Catteruccia F, Crisanti A. Developing transgenic Anopheles mosquitoes for the sterile insect technique. Genetica. 2011 Jan;139(1):33-9.

T Nolan, G Cecere, C Mancone, T Alonzi, M Tripodi, C Catalanotto C cogoni The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A Nucleic Acids Research 2008, 36 (2), 532-538

Nolan T, Braccini L, Azzalin, De Toni A, Macino G, Cogoni C.  The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa. Nucleic Acids Research 2005 Mar 14;33(5):1564-73

Catteruccia F*, Nolan T*, Loukeris TG, Blass C, Savakis C, Kafatos FC, Crisanti A. Stable germline transformation of the malaria mosquito Anopheles stephensi. Nature. 2000 Jun 22;405(6789):959-62. (* joint first authors)