Imperial College London

DrTeresaNorat

Faculty of MedicineSchool of Public Health

Academic Visitor
 
 
 
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+44 (0)20 7594 3454t.norat

 
 
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Location

 

509Variety Club WingSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

292 results found

Molina-Montes E, Wark PA, Sanchez M-J, Norat T, Jakszyn P, Lujan-Barroso L, Michaud DS, Crowe F, Allen N, Khaw K-T, Wareham N, Trichopoulou A, Adarakis G, Katarachia H, Skeie G, Henningsen M, Broderstad AR, Berrino F, Tumino R, Palli D, Mattiello A, Vineis P, Amiano P, Barricarte A, Huerta J-M, Duell EJ, Quiros J-R, Ye W, Sund M, Lindkvist B, Johansen D, Overvad K, Tjonneland A, Roswall N, Li K, Grote VA, Steffen A, Boeing H, Racine A, Boutron-Ruault M-C, Carbonnel F, Peeters PHM, Siersema PD, Fedirko V, Jenab M, Riboli E, Bueno-de-Mesquita Bet al., 2012, Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort, INTERNATIONAL JOURNAL OF CANCER, Vol: 131, Pages: E1134-E1147, ISSN: 0020-7136

Journal article

Aune D, Chan DSM, Vieira AR, Rosenblatt DAN, Vieira R, Greenwood DC, Cade JE, Burley VJ, Norat Tet al., 2012, Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies, ANNALS OF ONCOLOGY, Vol: 23, Pages: 2536-2546, ISSN: 0923-7534

Journal article

Druesne-Pecollo N, Touvier M, Barrandon E, Chan DSM, Norat T, Zelek L, Hercberg S, Latino-Martel Pet al., 2012, Excess body weight and second primary cancer risk after breast cancer: a systematic review and meta-analysis of prospective studies, BREAST CANCER RESEARCH AND TREATMENT, Vol: 135, Pages: 647-654, ISSN: 0167-6806

Journal article

May AM, Adema LE, Romaguera D, Vergnaud A-C, Agudo A, Ekelund U, Steffen A, Orfanos P, Slimani N, Rinaldi S, Mouw T, Rohrmann S, Hermann S, Boeing H, Bergmann MM, Jakobsen MU, Overvad K, Wareham NJ, Gonzalez C, Tjonneland A, Halkjaer J, Key TJ, Spencer EA, Hellstrom V, Manjer J, Hedblad B, Lund E, Braaten T, Clavel-Chapelon F, Boutron-Ruault M-C, Rodriguez L, Sanchez MJ, Dorronsoro M, Barricarte A, Maria Huerta J, Naska A, Trichopoulou A, Palli D, Pala V, Norat T, Mattiello A, Tumino R, van der Daphne A, Bueno-de-Mesquita HB, Riboli E, Peeters PHMet al., 2012, Determinants of non- response to a second assessment of lifestyle factors and body weight in the EPIC-PANACEA study, BMC Medical Research Methodology, Vol: 12, ISSN: 1471-2288

Background: This paper discusses whether baseline demographic, socio-economic, health variables, length offollow-up and method of contacting the participants predict non-response to the invitation for a secondassessment of lifestyle factors and body weight in the European multi-center EPIC-PANACEA study.Methods: Over 500.000 participants from several centers in ten European countries recruited between 1992 and2000 were contacted 2–11 years later to update data on lifestyle and body weight. Length of follow-up as well asthe method of approaching differed between the collaborating study centers. Non-responders were compared withresponders using multivariate logistic regression analyses.Results: Overall response for the second assessment was high (81.6%). Compared to postal surveys, centers wherethe participants completed the questionnaire by phone attained a higher response. Response was also high incenters with a short follow-up period. Non-response was higher in participants who were male (odds ratio 1.09(confidence interval 1.07; 1.11), aged under 40 years (1.96 (1.90; 2.02), living alone (1.40 (1.37; 1.43), less educated(1.35 (1.12; 1.19), of poorer health (1.33 (1.27; 1.39), reporting an unhealthy lifestyle and who had either a low(<18.5 kg/m2, 1.16 (1.09; 1.23)) or a high BMI (>25, 1.08 (1.06; 1.10); especially ≥30 kg/m2, 1.26 (1.23; 1.29)).Conclusions: Cohort studies may enhance cohort maintenance by paying particular attention to the subgroupsthat are most unlikely to respond and by an active recruitment strategy using telephone interviews.

Journal article

Jeurnink SM, Buchner FL, Bueno-de-Mesquita HB, Siersema PD, Boshuizen HC, Numans ME, Dahm CC, Overvad K, Tjonneland A, Roswall N, Clavel-Chapelon F, Boutron-Ruault MC, Morois S, Kaaks R, Teucher B, Boeing H, Buijsse B, Trichopoulou A, Benetou V, Zylis D, Palli D, Sieri S, Vineis P, Tumino R, Panico S, Ocke MC, Peeters PHM, Skeie G, Brustad M, Lund E, Sanchez-Cantalejo E, Navarro C, Amiano P, Ardanaz E, Ramon Quiros J, Hallmans G, Johansson I, Lindkvist B, Regner S, Khaw KT, Wareham N, Key TJ, Slimani N, Norat T, Vergnaud AC, Romaguera D, Gonzalez CAet al., 2012, Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European prospective investigation into cancer and nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 131, Pages: E963-E973, ISSN: 0020-7136

Journal article

Wark PA, Lau R, Norat T, Kampman Eet al., 2012, Magnesium intake and colorectal tumor risk: a case-control study and meta-analysis, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 622-631, ISSN: 0002-9165

Journal article

Romieu I, Ferrari P, Rinaldi S, Slimani N, Jenab M, Olsen A, Tjonneland A, Overvad K, Boutron-Ruault M-C, Lajous M, Kaaks R, Teucher B, Boeing H, Trichopoulou A, Naska A, Vasilopoulo E, Sacerdote C, Tumino R, Masala G, Sieri S, Panico S, Bueno-de-Mesquita HB, Van-der-A D, van Gils CH, Peeters PHM, Lund E, Skeie G, Asli LA, Rodriguez L, Navarro C, Amiano P, Sanchez M-J, Barricarte A, Buckland G, Sonestedt E, Wirfalt E, Hallmans G, Johansson I, Key TJ, Allen NE, Khaw K-T, Wareham NJ, Norat T, Riboli E, Clavel-Chapelon Fet al., 2012, Dietary glycemic index and glycemic load and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC), AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 345-355, ISSN: 0002-9165

Journal article

Aune D, Chan DSM, Vieira AR, Rosenblatt DAN, Vieira R, Greenwood DC, Norat Tet al., 2012, Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 356-373, ISSN: 0002-9165

Journal article

Aune D, Vieira AR, Chan DSM, Rosenblatt DAN, Vieira R, Greenwood DC, Cade JE, Burley VJ, Norat Tet al., 2012, Height and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies, CANCER CAUSES & CONTROL, Vol: 23, Pages: 1213-1222, ISSN: 0957-5243

Journal article

Rohrmann S, Steinbrecher A, Linseisen J, Hermann S, May A, Luan J, Ekelund U, Overvad K, Tjonneland A, Halkjaer J, Fagherazzi G, Boutron-Ruault M-C, Clavel-Chapelon F, Agnoli C, Tumino R, Masala G, Mattiello A, Ricceri F, Travier N, Amiano P, Ardanaz E, Chirlaque M-D, Sanchez M-J, Rodriguez L, Nilsson LM, Johansson I, Hedblad B, Rosvall M, Lund E, Braaten T, Naska A, Orfanos P, Trichopoulou A, van den Berg S, Bueno-de-Mesquita HB, Bergmann MM, Steffen A, Kaaks R, Teucher B, Wareham NJ, Khaw K-T, Crowe FL, Illner A-K, Slimani N, Gallo V, Mouw T, Norat T, Peeters PHMet al., 2012, The association of education with long-term weight change in the EPIC-PANACEA cohort, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 66, Pages: 957-963, ISSN: 0954-3007

Journal article

Crowe FL, Key TJ, Appleby PN, Overvad K, Schmidt EB, Egeberg R, Tjonneland A, Kaaks R, Teucher B, Boeing H, Weikert C, Trichopoulou A, Ouranos V, Valanou E, Masala G, Sieri S, Panico S, Tumino R, Matullo G, Bueno-de-Mesquita HB, Boer JMA, Beulens JWJ, van der Schouw YT, Quiros JR, Buckland G, Sanchez M-J, Dorronsoro M, Huerta JM, Moreno-Iribas C, Hedblad B, Jansson JH, Wennberg P, Khaw K-T, Wareham N, Ferrari P, Illner A-K, Chuang S-C, Norat T, Danesh J, Riboli Eet al., 2012, Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 66, Pages: 950-956, ISSN: 0954-3007

Journal article

Romaguera D, Vergnaud A-C, Peeters PH, van Gils CH, Chan DSM, Ferrari P, Romieu I, Jenab M, Slimani N, Clavel-Chapelon F, Fagherazzi G, Perquier F, Kaaks R, Teucher B, Boeing H, von Ruesten A, Tjonneland A, Olsen A, Dahm CC, Overvad K, Ramon Quiros J, Gonzalez CA, Jose Sanchez M, Navarro C, Barricarte A, Dorronsoro M, Khaw K-T, Wareham NJ, Crowe FL, Key TJ, Trichopoulou A, Lagiou P, Bamia C, Masala G, Vineis P, Tumino R, Sieri S, Panico S, May AM, Bueno-de-Mesquita HB, Buechner FL, Wirfaelt E, Manjer J, Johansson I, Hallmans G, Skeie G, Benjaminsen Borch K, Parr CL, Riboli E, Norat Tet al., 2012, Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 150-163, ISSN: 0002-9165

Journal article

Chuang S-C, Norat T, Murphy N, Olsen A, Tjonneland A, Overvad K, Boutron-Ruault MC, Perquier F, Dartois L, Kaaks R, Teucher B, Bergmann MM, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Grioni S, Sacerdote C, Panico S, Palli D, Tumino R, Peeters PHM, Bueno-de-Mesquita B, Ros MM, Brustad M, Asli LA, Skeie G, Quiros JR, Gonzalez CA, Sanchez M-J, Navarro C, Aicua EA, Dorronsoro M, Drake I, Sonestedt E, Johansson I, Hallmans G, Key T, Crowe F, Khaw K-T, Wareham N, Ferrari P, Slimani N, Romieu I, Gallo V, Riboli E, Vineis Pet al., 2012, Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 164-174, ISSN: 0002-9165

Journal article

Aune D, Chan DSM, Vieira AR, Rosenblatt DAN, Vieira R, Greenwood DC, Norat Tet al., 2012, Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies, BREAST CANCER RESEARCH AND TREATMENT, Vol: 134, Pages: 479-493, ISSN: 0167-6806

Journal article

Travis RC, Allen NE, Appleby PN, Price A, Kaaks R, Chang-Claude J, Boeing H, Aleksandrova K, Tjonneland A, Johnsen NF, Overvad K, Ramon Quiros J, Gonzalez CA, Molina-Montes E, Jose Sanchez M, Larranaga N, Huerta Castano JM, Ardanaz E, Khaw K-T, Wareham N, Trichopoulou A, Karapetyan T, Rafnsson SB, Palli D, Krogh V, Tumino R, Vineis P, Bueno-de-Mesquita HB, Stattin P, Johansson M, Fedirko V, Norat T, Siddiq A, Riboli E, Key TJet al., 2012, Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC, CANCER CAUSES & CONTROL, Vol: 23, Pages: 1163-1171, ISSN: 0957-5243

Journal article

Ekelund U, Palla L, Brage S, Franks PW, Peters T, Balkau B, Diaz MJT, Huerta JM, Agnoli C, Arriola L, Ardanaz E, Boeing H, Clavel-Chapelon F, Crowe F, Fagherazzi G, Groop L, Hainaut P, Johnsen NF, Kaaks R, Khaw KT, Key TJ, de Lauzon-Guillain B, May A, Monninkhof E, Navarro C, Nilsson P, Ostergaard JN, Norat T, Overvad K, Palli D, Panico S, Redondo ML, Ricceri F, Rolandsson O, Romaguera D, Romieu I, Sanchez Perez MJ, Slimani N, Spijkerman A, Teucher B, Tjonneland A, Travier N, Tumino R, Vos W, Vigl M, Sharp S, Langenberg C, Forouhi N, Riboli E, Feskens E, Wareham NJet al., 2012, Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study, DIABETOLOGIA, Vol: 55, Pages: 1944-1952, ISSN: 0012-186X

Journal article

Hurst R, Hooper L, Norat T, Lau R, Aune D, Greenwood DC, Vieira R, Collings R, Harvey LJ, Sterne JAC, Beynon R, Savovic J, Fairweather-Tait SJet al., 2012, Selenium and prostate cancer: systematic review and meta-analysis, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 111-122, ISSN: 0002-9165

Journal article

Murphy N, Norat T, Ferrari P, Jenab M, Bueno-de-Mesquita B, Skeie G, Dahm CC, Overvad K, Olsen A, Tjonneland A, Clavel-Chapelon F, Boutron-Ruault MC, Racine A, Kaaks R, Teucher B, Boeing H, Bergmann MM, Trichopoulou A, Trichopoulos D, Lagiou P, Palli D, Pala V, Panico S, Tumino R, Vineis P, Siersema P, van Duijnhoven F, Peeters PHM, Hjartaker A, Engeset D, Gonzalez CA, Sanchez M-J, Dorronsoro M, Navarro C, Ardanaz E, Quiros JR, Sonestedt E, Ericson U, Nilsson L, Palmqvist R, Khaw K-T, Wareham N, Key TJ, Crowe FL, Fedirko V, Wark PA, Chuang S-C, Riboli Eet al., 2012, Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC), PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Langenberg C, Sharp SJ, Schulze MB, Rolandsson O, Overvad K, Forouhi NG, Spranger J, Drogan D, Maria Huerta J, Arriola L, de Lauzon-Guillan B, Tormo M-J, Ardanaz E, Balkau B, Beulens JWJ, Boeing H, Bueno-de-Mesquita HB, Clavel-Chapelon F, Crowe FL, Franks PW, Gonzalez CA, Grioni S, Halkjaer J, Hallmans G, Kaaks R, Kerrison ND, Key TJ, Khaw KT, Mattiello A, Nilsson P, Norat T, Palla L, Palli D, Panico S, Ramon Quiros J, Romaguera D, Romieu I, Sacerdote C, Sanchez M-J, Slimani N, Sluijs I, Spijkerman AMW, Teucher B, Tjonneland A, Tumino R, Daphne LVDA, van der Schouw YT, Feskens EJM, Riboli E, Wareham NJet al., 2012, Long-Term Risk of Incident Type 2 Diabetes and Measures of Overall and Regional Obesity: The EPIC-InterAct Case-Cohort Study, PLOS Medicine, Vol: 9, ISSN: 1549-1277

Background: Waist circumference (WC) is a simple and reliable measure of fat distribution that may add to the prediction oftype 2 diabetes (T2D), but previous studies have been too small to reliably quantify the relative and absolute risk of futurediabetes by WC at different levels of body mass index (BMI).Methods and Findings: The prospective InterAct case-cohort study was conducted in 26 centres in eight Europeancountries and consists of 12,403 incident T2D cases and a stratified subcohort of 16,154 individuals from a total cohort of340,234 participants with 3.99 million person-years of follow-up. We used Prentice-weighted Cox regression and randomeffects meta-analysis methods to estimate hazard ratios for T2D. Kaplan-Meier estimates of the cumulative incidence of T2Dwere calculated. BMI and WC were each independently associated with T2D, with WC being a stronger risk factor in womenthan in men. Risk increased across groups defined by BMI and WC; compared to low normal weight individuals (BMI 18.5–22.4 kg/m2) with a low WC (,94/80 cm in men/women), the hazard ratio of T2D was 22.0 (95% confidence interval 14.3;33.8) in men and 31.8 (25.2; 40.2) in women with grade 2 obesity (BMI$35 kg/m2) and a high WC (.102/88 cm). Among thelarge group of overweight individuals, WC measurement was highly informative and facilitated the identification of asubgroup of overweight people with high WC whose 10-y T2D cumulative incidence (men, 70 per 1,000 person-years;women, 44 per 1,000 person-years) was comparable to that of the obese group (50–103 per 1,000 person-years in men and28–74 per 1,000 person-years in women).Conclusions: WC is independently and strongly associated with T2D, particularly in women, and should be more widelymeasured for risk stratification. If targeted measurement is necessary for reasons of resource scarcity, measuring WC inoverweight individuals may be an effective strategy, since it identifies a high-risk subgroup of individuals who coul

Journal article

Aune D, Chan DSM, Greenwood DC, Vieira AR, Rosenblatt DAN, Vieira R, Norat Tet al., 2012, Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies, ANNALS OF ONCOLOGY, Vol: 23, Pages: 1394-1402, ISSN: 0923-7534

Journal article

Braem MGM, Onland-Moret NC, Schouten LJ, Tjonneland A, Hansen L, Dahm CC, Overvad K, Lukanova A, Dossus L, Floegel A, Boeing H, Clavel-Chapelon F, Chabbert-Buffet N, Fagherazzi G, Trichopoulou A, Benetou V, Goufa I, Pala V, Galasso R, Mattiello A, Sacerdote C, Palli D, Tumino R, Gram IT, Lund E, Gavrilyuk O, Sanchez M-J, Quiros R, Gonzales CA, Dorronsoro M, Huerta Castano JM, Barricarte Gurrea A, Idahl A, Ohlson N, Lundin E, Jirstrom K, Witfalt E, Allen NE, Tsilidis KK, Kaw K-T, Bueno-de-Mesquita HB, Dik VK, Rinaldi S, Fedirko V, Norat T, Riboli E, Kaaks R, Peeters PHMet al., 2012, Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 95, Pages: 1172-1181, ISSN: 0002-9165

Journal article

Leufkens AM, van Duijnhoven FJB, Woudt SHS, Siersema PD, Jenab M, Jansen EHJM, Pischon T, Tjonneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel-Chapelon F, Morois S, Palli D, Pala V, Tumino R, Vineis P, Panico S, Kaaks R, Lukanova A, Boeing H, Aleksandrova K, Trichopoulou A, Trichopouios D, Dilis V, Peeters PH, Skeie G, Gonzalez CA, Argueelles M, Sanchez M-J, Dorronsoro M, Huerta JM, Ardanaz E, Hallmans G, Palmqvist R, Khaw K-T, Wareham N, Allen NE, Crowe FL, Fedirko V, Norat T, Riboli E, Bueno-de-Mesquita HBet al., 2012, Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer: A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 175, Pages: 653-663, ISSN: 0002-9262

Journal article

Fedirko V, Riboli E, Tjonneland A, Ferrari P, Olsen A, Bueno-de-Mesquita HB, van Duijnhoven FJB, Norat T, Jansen EHJM, Dahm CC, Overvad K, Boutron-Ruault M-C, Clavel-Chapelon F, Racine A, Lukanova A, Teucher B, Boeing H, Aleksandrova K, Trichopoulou A, Benetou V, Trichopoulos D, Grioni S, Vineis P, Panico S, Palli D, Tumino R, Siersema PD, Peeters PH, Skeie G, Brustad M, Chirlaque M-D, Barricarte A, Ramon Quiros J, Jose Sanchez M, Dorronsoro M, Bonet C, Palmqvist R, Hallmans G, Key TJ, Crowe F, Khaw K-T, Wareham N, Romieu I, McKay J, Wark PA, Romaguera D, Jenab Met al., 2012, Prediagnostic 25-Hydroxyvitamin D, <i>VDR</i> and <i>CASR</i> Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 21, Pages: 582-593, ISSN: 1055-9965

Journal article

Aune D, Chan DSM, Lau R, Vieira R, Greenwood DC, Kampman E, Norat Tet al., 2012, Carbohydrates, glycemic index, glycemic load, and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, CANCER CAUSES & CONTROL, Vol: 23, Pages: 521-535, ISSN: 0957-5243

Journal article

Aune D, Greenwood DC, Chan DSM, Vieira R, Vieira AR, Rosenblatt DAN, Cade JE, Burley VJ, Norat Tet al., 2012, Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies, ANNALS OF ONCOLOGY, Vol: 23, Pages: 843-852, ISSN: 0923-7534

Journal article

Freisling H, van Bakel MME, Biessy C, May AM, Byrnes G, Norat T, Rinaldi S, de Magistris MS, Grioni S, Bueno-de-Mesquita HB, Ocke MC, Kaaks R, Teucher B, Vergnaud A-C, Romaguera D, Sacerdote C, Palli D, Crowe FL, Tumino R, Clavel-Chapelon F, Boutron-Ruault M-C, Khaw K-T, Wareham NJ, Trichopoulou A, Naska A, Orfanos P, Boeing H, Illner A-K, Riboli E, Peeters PH, Slimani Net al., 2012, Dietary reporting errors on 24 h recalls and dietary questionnaires are associated with BMI across six European countries as evaluated with recovery biomarkers for protein and potassium intake, BRITISH JOURNAL OF NUTRITION, Vol: 107, Pages: 910-920, ISSN: 0007-1145

Journal article

Rohrmann S, Grote VA, Becker S, Rinaldi S, Tjonneland A, Roswall N, Gronbaek H, Overvad K, Boutron-Ruault MC, Clavel-Chapelon F, Racine A, Teucher B, Boeing H, Drogan, Dilis V, Lagiou P, Trichopoulou A, Palli D, Tagliabue G, Tumino R, Vineis P, Mattiello A, Rodriguez L, Duell EJ, Molina-Montes E, Dorronsoro M, Huerta J-M, Ardanaz E, Jeurnink S, Peeters PHM, Lindkvist B, Johansen D, Sund M, Ye W, Khaw K-T, Wareham NJ, Allen NE, Crowe FL, Fedirko V, Jenab M, Michaud DS, Norat T, Riboli E, Bueno-de-Mesquita HB, Kaaks Ret al., 2012, Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition, British Journal of Cancer, Vol: 106, Pages: 1004-1010, ISSN: 1532-1827

BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation andapoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and wasexamined here in a case – control study nested within the European Prospective Investigation into Cancer and Nutrition.METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used tocompute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables.RESULTS: Neither circulating levels of IGF-I (OR¼ 1.21, 95% CI 0.75–1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR¼ 1.00, 95%CI 0.66–1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR¼ 1.22, 95% CI 0.75–1.97, P-trend 0.27),were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I withconcurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR¼ 1.72, 95% CI 1.05–2.83; P-interaction¼ 0.154).CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreaticcancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with verylow levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk

Journal article

Peters T, Brage S, Westgate K, Franks PW, Gradmark A, Diaz MJT, Huerta JM, Bendinelli B, Vigl M, Boeing H, Wendel-Vos W, Spijkerman A, Benjaminsen-Borch K, Valanou E, Guillain BDL, Clavel-Chapelon F, Sharp S, Kerrison N, Langenberg C, Arriola L, Barricarte A, Gonzales C, Grioni S, Kaaks R, Key T, Khaw KT, May A, Nilsson P, Norat T, Overvad K, Palli D, Panico S, Quiros JR, Ricceri F, Sanchez M-J, Slimani N, Tjonneland A, Tumino R, Feskens E, Riboli E, Ekelund U, Wareham Net al., 2012, Validity of a short questionnaire to assess physical activity in 10 European countries, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 27, Pages: 15-25, ISSN: 0393-2990

Journal article

Vergnaud A-C, Norat T, Romaguera D, Mouw T, May AM, Romieu I, Freisling H, Slimani N, Boutron-Ruault M-C, Clavel-Chapelon F, Morois S, Kaaks R, Teucher B, Boeing H, Buijsse B, Tjonneland A, Halkjaer J, Overvad K, Jakobsen MU, Rodriguez L, Agudo A, Sanchez M-J, Amiano P, Maria Huerta J, Barricarte Gurrea A, Wareham N, Khaw K-T, Crowe F, Orfanos P, Naska A, Trichopoulou A, Masala G, Pala V, Tumino R, Sacerdote C, Mattiello A, Bueno-de-Mesquita HB, van Duijnhoven FJB, Drake I, Wirfalt E, Johansson I, Hallmans G, Engeset D, Braaten T, Parr CL, Odysseos A, Riboli E, Peeters PHMet al., 2012, Fruit and vegetable consumption and prospective weight change in participants of the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home, and Obesity study, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 95, Pages: 184-193, ISSN: 0002-9165

Journal article

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