DrTeresaNorat

Jenab M, McKay J, Bueno-de-Mesquita HB, van Duijnhoven FJB, Ferrari P, Slimani N, Jansen EHJM, Pischon T, Rinaldi S, Tjonneland A, Olsen A, Overvad K, Boutron-Ruault M-C, Clavel-Chapelon F, Engel P, Kaaks R, Linseisen J, Boeing H, Fisher E, Trichopoulou A, Dilis V, Oustoglou E, Berrino F, Vineis P, Mattiello A, Masala G, Tumino R, Vrieling A, van Gils CH, Peeters PH, Brustad M, Lund E, Chirlaque M-D, Barricarte A, Rodriguez Suarez L, Molina E, Dorronsoro M, Sala N, Hallmans G, Palmqvist R, Roddam A, Key TJ, Khaw K-T, Bingham S, Boffetta P, Autier P, Byrnes G, Norat T, Riboli Eet al., 2009, Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European Populations, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 18, Pages: 2485-2491, ISSN: 1055-9965

• Author Web Link
• Cite
• Citations: 64

Allen NE, Roddam AW, Sieri S, Boeing H, Jakobsen MU, Overvad K, Tjonneland A, Halkjaer J, Vineis P, Contiero P, Palli D, Tumino R, Mattiello A, Kaaks R, Rohrmann S, Trichopoulou A, Zilis D, Koumantaki Y, Peeters PH, Bueno-de-Mesquita HB, Barricarte A, Rodriguez L, Dorronsoro M, Sanchez M-J, Dolores Chirlaque M, Esquius L, Manjer J, Wallstrom P, Ljungberg B, Hallmans G, Bingham S, Khaw K-T, Boffetta P, Norat T, Mouw T, Riboli Eet al., 2009, A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 125, Pages: 982-987, ISSN: 0020-7136

• Author Web Link
• Cite
• Citations: 23

Weikert C, Dietrich T, Boeing H, Bergmann MM, Boutron-Ruault MC, Clavel-Chapelon F, Allen N, Key T, Lund E, Olsen A, Tjonneland A, Overvad K, Rohrmann S, Linseisen J, Pischon T, Trichopoulou A, Weinehall L, Johansson I, Sanchez M-J, Agudo A, Barricarte A, Amiano P, Chirlaque M-D, Ramon Quiros J, Wirfalt E, Peeters PH, Bueno-de-Mesquita HB, Vrieling A, Pala V, Palli D, Vineis P, Tumino R, Panico S, Bingham S, Khaw K-T, Norat T, Jenab M, Ferrari P, Slimani N, Riboli Eet al., 2009, Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European prospective investigation into cancer and nutrition (EPIC) study, INTERNATIONAL JOURNAL OF CANCER, Vol: 125, Pages: 406-412, ISSN: 0020-7136

• Author Web Link
• Cite
• Citations: 34

Crowe FL, Key TJ, Allen NE, Appleby PN, Roddam A, Overvad K, Grønbaek H, Tjønneland A, Halkjaer J, Dossus L, Boeing H, Kröger J, Trichopoulou A, Dilis V, Trichopoulos D, Boutron-Ruault M-C, De Lauzon B, Clavel-Chapelon F, Palli D, Berrino F, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Vrieling A, van Gils CH, Peeters PHM, Gram IT, Skeie G, Lund E, Rodríguez L, Jakszyn P, Molina-Montes E, Tormo MJ, Barricarte A, Larrañaga N, Khaw K-T, Bingham S, Rinaldi S, Slimani N, Norat T, Gallo V, Riboli E, Kaaks Ret al., 2009, The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition., Cancer Epidemiol Biomarkers Prev, Vol: 18, Pages: 1333-1340, ISSN: 1055-9965

Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.

• Abstract
• Author Web Link
• Cite

van Duijnhoven FJB, Bueno-De-Mesquita HB, Ferrari P, Jenab M, Boshuizen HC, Ros MM, Casagrande C, Tjønneland A, Olsen A, Overvad K, Thorlacius-Ussing O, Clavel-Chapelon F, Boutron-Ruault M-C, Morois S, Kaaks R, Linseisen J, Boeing H, Nöthlings U, Trichopoulou A, Trichopoulos D, Misirli G, Palli D, Sieri S, Panico S, Tumino R, Vineis P, Peeters PH, van Gils CH, Ocké MC, Lund E, Engeset D, Skeie G, Suárez LR, González CA, Sánchez M-J, Dorronsoro M, Navarro C, Barricarte A, Berglund G, Manjer J, Hallmans G, Palmqvist R, Bingham SA, Khaw K-T, Key TJ, Allen NE, Boffetta P, Slimani N, Rinaldi S, Gallo V, Norat T, Riboli Eet al., 2009, Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition., Am J Clin Nutr, Vol: 89, Pages: 1441-1452

BACKGROUND: A high consumption of fruit and vegetables is possibly associated with a decreased risk of colorectal cancer (CRC). However, the findings to date are inconsistent. OBJECTIVE: We examined the relation between self-reported usual consumption of fruit and vegetables and the incidence of CRC. DESIGN: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 452,755 subjects (131,985 men and 320,770 women) completed a dietary questionnaire in 1992-2000 and were followed up for cancer incidence and mortality until 2006. A multivariate Cox proportional hazard model was used to estimate adjusted hazard ratios (HRs) and 95% CIs. RESULTS: After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers. This modifying effect was found for fruit and vegetables combined and for vegetables alone (P for interaction < 0.01 for both). CONCLUSIONS: These findings suggest that a high consumption of fruit and vegetables is associated with a reduced risk of CRC, especially of colon cancer. This effect may depend on smoking status.

• Abstract
• Author Web Link
• Cite

Besson H, Ekelund U, Luan J, May AM, Sharp S, Travier N, Agudo A, Slimani N, Rinaldi S, Jenab M, Norat T, Mouw T, Rohrmann S, Kaaks R, Bergmann M, Boeing H, Clavel-Chapelon F, Boutron-Ruault MC, Overvad K, Andreasen EL, Johnsen NF, Halkjaer J, Gonzalez C, Rodriguez L, Sanchez MJ, Arriola L, Barricarte A, Navarro C, Key TJ, Spencer EA, Orfanos P, Naska A, Trichopoulou A, Manjer J, Wirfaelt E, Lund E, Palli D, Agnoli C, Vineis P, Panico S, Tumino R, Bueno-de-Mesquita HB, van den Berg SW, Odysseos AD, Riboli E, Wareham NJ, Peeters PHet al., 2009, A cross-sectional analysis of physical activity and obesity indicators in European participants of the EPIC-PANACEA study, INTERNATIONAL JOURNAL OF OBESITY, Vol: 33, Pages: 497-506, ISSN: 0307-0565

• Author Web Link
• Cite
• Citations: 71

Druesne-Pecollo N, Tehard B, Mallet Y, Gerber M, Norat T, Hercberg S, Latino-Martel Pet al., 2009, Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer, LANCET ONCOLOGY, Vol: 10, Pages: 173-180, ISSN: 1470-2045

• Author Web Link
• Cite
• Citations: 163

Campa D, McKay J, Sinilnikova O, Husing A, Vogel U, Hansen RD, Overvad K, Witt PM, Clavel-Chapelon F, Boutron-Ruault MC, Chajes V, Rohrmann S, Chang-Claude J, Boeing H, Fisher E, Trichopoulou A, Trichopoulos D, Palli D, Villarini A, Sacerdote C, Mattiello A, Tumino R, Peeters PH, van Gils CH, Bas Bueno-de-Mesquita H, Lund E, Chirlaque MD, Sala N, Suarez LR, Barricarte A, Dorronsoro M, Sanchez MJ, Lenner P, Hallmans G, Tsilidis K, Bingham S, Khaw KT, Gallo V, Norat T, Riboli E, Rinaldi S, Lenoir G, Tavtigian SV, Canzian F, Kaaks Ret al., 2009, Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk, Breast Cancer Res Treat, Vol: 118, Pages: 565-574, ISSN: 1573-7217

Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

• Abstract
• Author Web Link
• Cite

Crowe FL, Key TJ, Allen NE, Appleby PN, Roddam A, Overvad K, Gronbaek H, Tjonneland A, Halkjaer J, Dossus L, Boeing H, Kroger J, Trichopoulou A, Dilis V, Trichopoulos D, Boutron-Ruault MC, De Lauzon B, Clavel-Chapelon F, Palli D, Berrino F, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Vrieling A, van Gils CH, Peeters PH, Gram IT, Skeie G, Lund E, Rodriguez L, Jakszyn P, Molina-Montes E, Tormo MJ, Barricarte A, Larranaga N, Khaw KT, Bingham S, Rinaldi S, Slimani N, Norat T, Gallo V, Riboli E, Kaaks Ret al., 2009, The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition, Vol: 18, Pages: 1333-1340, ISSN: 1055-9965

Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.

• Abstract
• Author Web Link
• Cite

van Duijnhoven FJ, Bueno-De-Mesquita HB, Ferrari P, Jenab M, Boshuizen HC, Ros MM, Casagrande C, Tjonneland A, Olsen A, Overvad K, Thorlacius-Ussing O, Clavel-Chapelon F, Boutron-Ruault MC, Morois S, Kaaks R, Linseisen J, Boeing H, Nothlings U, Trichopoulou A, Trichopoulos D, Misirli G, Palli D, Sieri S, Panico S, Tumino R, Vineis P, Peeters PH, van Gils CH, Ocke MC, Lund E, Engeset D, Skeie G, Suarez LR, Gonzalez CA, Sanchez MJ, Dorronsoro M, Navarro C, Barricarte A, Berglund G, Manjer J, Hallmans G, Palmqvist R, Bingham SA, Khaw KT, Key TJ, Allen NE, Boffetta P, Slimani N, Rinaldi S, Gallo V, Norat T, Riboli Eet al., 2009, Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition, American Journal Clinical Nutrition, Vol: 89, Pages: 1441-1452, ISSN: 1938-3207

BACKGROUND: A high consumption of fruit and vegetables is possibly associated with a decreased risk of colorectal cancer (CRC). However, the findings to date are inconsistent. OBJECTIVE: We examined the relation between self-reported usual consumption of fruit and vegetables and the incidence of CRC. DESIGN: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 452,755 subjects (131,985 men and 320,770 women) completed a dietary questionnaire in 1992-2000 and were followed up for cancer incidence and mortality until 2006. A multivariate Cox proportional hazard model was used to estimate adjusted hazard ratios (HRs) and 95% CIs. RESULTS: After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers. This modifying effect was found for fruit and vegetables combined and for vegetables alone (P for interaction < 0.01 for both). CONCLUSIONS: These findings suggest that a high consumption of fruit and vegetables is associated with a reduced risk of CRC, especially of colon cancer. This effect may depend on smoking status.

• Abstract
• Author Web Link
• Cite

Sieri S, Krogh V, Ferrari P, Berrino F, Pala V, Thiebaut ACM, Tjonneland A, Olsen A, Overvad K, Jakobsen MU, Clavel-Chapelon F, Chajes V, Boutron-Ruault M-C, Kaaks R, Linseisen J, Boeing H, Noethlings U, Trichopoulou A, Naska A, Lagiou P, Panico S, Palli D, Vineis P, Tumino R, Lund E, Kumle M, Skeie G, Gonzalez CA, Ardanaz E, Amiano P, Tormo MJ, Martinez-Garcia C, Quiros JR, Berglund G, Gullberg B, Hallmans G, Lenner P, Bueno-de-Mesquita HB, van Duijnhoven FJB, Peeters PHM, van Gils CH, Key TJ, Crowe FL, Bingham S, Khaw KT, Rinaldi S, Slimani N, Jenab M, Norat T, Riboli Eet al., 2008, Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 88, Pages: 1304-1312, ISSN: 0002-9165

• Author Web Link
• Cite
• Citations: 119

Lumbreras B, Garte S, Overvad K, Tjonneland A, Clavel-Chapelon F, Linseisen JP, Boeing H, Trichopoulou A, Palli D, Peluso M, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E, Martinez C, Dorronsoro M, Barricarte A, Chirlaque MD, Quiros JR, Berglund G, Hallmans G, Day NE, Key TJ, Saracci R, Kaaks R, Malaveille C, Ferrari P, Boffetta P, Norat T, Riboli E, Gonzalez CA, Vineis Pet al., 2008, Meat intake and bladder cancer in a prospective study: A role for heterocyclic aromatic amines? (Cancer Causes and Control DOI: 10.1007/s10552-008-9121-1), Cancer Causes and Control, Vol: 19, Pages: 657-658, ISSN: 0957-5243

• Cite

Norat T, Bowman R, Luben R, Welch A, Khaw KT, Wareham N, Bingham Set al., 2008, Blood pressure and interactions between the angiotensin polymorphism AGT M235T and sodium intake: a cross-sectional population study, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 88, Pages: 392-397, ISSN: 0002-9165

• Author Web Link
• Cite
• Citations: 32

Lumbreras B, Garte S, Overvad K, Tjonneland A, Clavel-Chapelon F, Linseisen JP, Boeing H, Trichopoulou A, Palli D, Peluso M, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E, Martinez C, Dorronsoro M, Barricarte A, Chirlaque M-D, Quiros JR, Berglund G, Hallmans G, Day NE, Key TJ, Saracci R, Kaaks R, Malaveille C, Ferrari P, Boffetta P, Norat T, Riboli E, Gonzalez CA, Vineis Pet al., 2008, Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?, CANCER CAUSES & CONTROL, Vol: 19, Pages: 649-656, ISSN: 0957-5243

• Author Web Link
• Cite
• Citations: 34

Ferrari P, Day NE, Boshuizen HC, Roddam A, Hoffmann K, Thiebaut A, Pera G, Overvad K, Lund E, Trichopoulou A, Tumino R, Gullberg B, Norat T, Slimani N, Kaaks R, Riboli Eet al., 2008, The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 37, Pages: 368-378, ISSN: 0300-5771

• Author Web Link
• Cite
• Citations: 98

Weikert S, Boeing H, Pischon T, Weikert C, Olsen A, Tjonneland A, Overvad K, Becker N, Linseisen J, Trichopoulou A, Mountokalakis T, Trichopoulos D, Sieri S, Palli D, Vineis P, Panico S, Peeters PHM, Bueno-De-Mesquita HB, Verschuren WMM, Ljungberg B, Hallmans G, Berglund G, Gonzalez CA, Dorronsoro M, Barricarte A, Tormo MJ, Allen N, Roddam A, Bingham S, Khaw K-T, Rinaldi S, Ferrari P, Norat T, Riboli Eet al., 2008, Blood pressure and risk of renal cell carcinoma in the european prospective investigation into cancer and nutrition, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 167, Pages: 438-446, ISSN: 0002-9262

• Author Web Link
• Cite
• Citations: 128

Khan AE, Gallo V, Linseisen J, Kaaks R, Rohrmann S, Raaschou-Nielsen O, Tjonneland A, Johnsen HE, Overvad K, Bergmann MM, Boeing H, Benetou V, Psaltopoulou T, Trichopoulou A, Masala G, Mattiello A, Grioni S, Tumino R, Vermeulen RC, Peeters PH, Bueno-de-Mesquita HB, Ros MM, Lund E, Ardanaz E, Chirlaque MD, Jakszyn P, Larranaga N, Losada A, Becker N, Nieters A, Martinez-Garcia C, Agren A, Hallmans G, Berglund G, Manjer J, Allen NE, Key TJ, Bingham S, Khaw KT, Slimani N, Ferrari P, Boffetta P, Norat T, Vineis P, Riboli Eet al., 2008, Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition, Vol: 93, Pages: 842-850, ISSN: 1592-8721

BACKGROUND: Non-Hodgkin's lymphomas are a heterogeneous group of neoplasms arising from the lymphopoietic system including a wide range of subtypes of either B-cell or T-cell lymphomas. The few established risk factors for the development of these neoplasms include viral infections and immunological abnormalities, but their etiology remains largely unknown. Evidence suggests that certain medical conditions may be linked, through immunosuppression, to the risk of non-Hodgkin's lymphoma. Multiple myeloma is a neoplasm of plasma cells that accounts for approximately 15% of lymphopoietic cancers. Increases in the incidence of non-Hodgkin's lymphoma and multiple myeloma in the past implicate environmental factors as potential causal agents. DESIGN AND METHODS: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,213 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma (594 men; 619 women) were identified during a follow-up of 8.5 years. Cox proportional hazard models were used to explore the association between self-reported diabetes, diagnosed after 30 years of age, and the risk of non-Hodgkin's lymphoma overall and multiple myeloma and various lymphoma subtypes. RESULTS: We found no association between a personal history of diabetes and the risk of non-Hodgkin's lymphoma overall in men (HR: 1.28, 95% CI: 0.89-1.84), in women (HR: 0.71, 95% CI: 0.41- 1.24), or in men and women combined (HR: 1.09, 95% CI: 0.80-1.47). Among the B-non-Hodgkin's lymphoma subtypes, we observed a statistically significant increased risk of B-cell chronic lymphocytic leukemia (HR: 2.0, 95% CI: 1.04-3.86) in men, but not in women (HR: 1.07, 95% CI: 0.33-3.43). CONCLUSIONS: This prospective study did not provide evidence for a role of self-reported diabetes in the etiology of non-Hodgkin's lymphoma overall or multiple myeloma. We found an increased risk of B-cell chronic lymphocytic leukemia among men with diabetes, but not among women.

• Abstract
• Author Web Link
• Cite

Trichopoulou A, Bamia C, Norat T, Overvad K, Schmidt EB, Tjonneland A, Halkjaer J, Clavel-Chapelon F, Vercambre M-N, Boutron-Ruault M-C, Linseisen J, Rohrmann S, Boeing H, Weikert C, Benetou V, Psaltopoulou T, Orfanos P, Boffetta P, Masala G, Pala V, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Ocke MC, Peeters PH, Van der Schouw YT, Gonzalez C, Sanchez MJ, Chirlaque MD, Moreno C, Larranaga N, Van Guelpen B, Jansson J-H, Bingham S, Khaw K-T, Spencer EA, Key T, Riboli E, Trichopoulos Det al., 2007, Modified Mediterranean diet and survival after myocardial infarction: the EPIC-Elderly study, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 22, Pages: 871-881, ISSN: 0393-2990

• Author Web Link
• Cite
• Citations: 84

Ferrari P, Jenab M, Norat T, Moskal A, Slimani N, Olsen A, Tjonneland A, Overvad K, Jensen MK, Boutron-Ruault M-C, Clavel-Chapelon F, Morois S, Rohrmann S, Linseisen J, Boeing H, Bergmann M, Kontopoulou D, Trichopoulou A, Kassapa C, Masala G, Krogh V, Vineis P, Panico S, Tumino R, van Gils CH, Peeters P, Bueno-de-Mesquita HB, Ocke MC, Skeie G, Lund E, Agudo A, Ardanaz E, Lopez DC, Sanchez M-J, Quiros JR, Amiano P, Berglund G, Manjer J, Palmqvist R, Van Guelpen B, Allen N, Key T, Bingham S, Mazuir M, Boffetta P, Kaaks R, Riboli Eet al., 2007, Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC), INTERNATIONAL JOURNAL OF CANCER, Vol: 121, Pages: 2065-2072, ISSN: 0020-7136

• Author Web Link
• Cite
• Citations: 188

Jenab M, Riboli E, Cleveland RJ, Norat T, Rinaldi S, Nieters A, Biessy C, Tjonneland A, Olsen A, Overvad K, Gronbaek H, Clavel-Chapelon F, Boutron-Ruault M-C, Linseisen J, Boeing H, Pischon T, Trichopoulos D, Oikonomou E, Trichopoulou A, Panico S, Vineis P, Berrino F, Tumino R, Masala G, Peters PH, van Gils CH, Bueno-de-Mesquita HB, Ocke MC, Lund E, Mendez MA, Tormo MJ, Barricarte A, Martinez-Garcia C, Dorronsoro M, Ramon Quiros J, Hallmans G, Palmqvist R, Berglund G, Manjer J, Key T, Allen NE, Bingham S, Khaw K-T, Cust A, Kaaks Ret al., 2007, Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 121, Pages: 368-376, ISSN: 0020-7136

• Author Web Link
• Cite
• Citations: 140

Rohrmann S, Becker N, Linseisen J, Nieters A, Rudiger T, Raaschou-Nielsen O, Tjonneland A, Johnsen HE, Overvad K, Kaaks R, Bergmann MM, Boeing H, Benetou V, Psaltopoulou T, Trichopoulou A, Masala G, Mattiello A, Krogh V, Tumino R, van Gils CH, Peeters PHM, Bueno-de-Mesquita HB, Ros MM, Lund E, Ardanaz E, Chirlaque M-D, Jakszyn P, Larranaga N, Losada A, Martinez-Garcia C, Agren A, Hallmans G, Berglund G, Manjer J, Allen NE, Key TJ, Bingham S, Khaw KT, Slimani N, Ferrari P, Boffetta P, Norat T, Vineis P, Riboli Eet al., 2007, Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC), CANCER CAUSES & CONTROL, Vol: 18, Pages: 537-549, ISSN: 0957-5243

• Author Web Link
• Cite
• Citations: 26

Bamia C, Trichopoulos D, Ferrari P, Overvad K, Bjerregaard L, Tjonneland A, Halkjaer J, Clavel-Chapelon F, Kesse E, Boutron-Ruault M-C, Boffetta P, Nagel G, Linseisen J, Boeing H, Hoffmann K, Kasapa C, Orfanou A, Travezea C, Slimani N, Norat T, Palli D, Pala V, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Waijers PMCM, Peeters PHM, van der Schouw YT, Berenguer A, Martinez-Garcia C, Navarro C, Barricarte A, Dorronsoro M, Berglund G, Wirfalt E, Johansson I, Johansson G, Bingham S, Khaw K-T, Spencer EA, Key T, Riboli E, Trichopoulou Aet al., 2007, Dietary patterns and survival of older Europeans:: The EPIC-Elderly study (European Prospective Investigation into Cancer and Nutrition), PUBLIC HEALTH NUTRITION, Vol: 10, Pages: 590-598, ISSN: 1368-9800

• Author Web Link
• Cite
• Citations: 100

Moskal A, Norat T, Ferrari P, Riboli Eet al., 2007, Alcohol intake and colorectal cancer risk: A dose-response meta-analysis of published cohort studies, INTERNATIONAL JOURNAL OF CANCER, Vol: 120, Pages: 664-671, ISSN: 0020-7136

• Author Web Link
• Cite
• Citations: 147

Nagel G, Linseisen J, Boshuizen HC, Pera G, Del Giudice G, Westert GP, Bueno-de-Mesquita HB, Allen NE, Key TJ, Numans ME, Peeters PHM, Sieri S, Siman H, Berglund G, Hallmans G, Stenling R, Martinez C, Arriola L, Barricarte A, Chirlaque MD, Quiros JR, Vineis P, Masala G, Palli D, Panico S, Tumino R, Bingham S, Boeing H, Bergmann MM, Overvad K, Boutron-Ruault M-C, Clavel-Chapelon F, Olsen A, Tjormeland A, Trichopoulou A, Bamia C, Soukara S, Sabourin J-C, Carneiro F, Slimani N, Jenab M, Norat T, Riboli E, Gonzalez CAet al., 2007, Socioeconomic positoon and the risk of gastric and overphageal cancer in the European Prospective into Cancer and Nutrition (EPIC-EURGAST), INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 36, Pages: 66-76, ISSN: 0300-5771

• Author Web Link
• Cite
• Citations: 70

Danesh J, Saracci R, Berglund G, Feskens E, Overvad K, Panico S, Thompson S, Fournier A, Clavel-Chapelon F, Canonico M, Kaaks R, Linseisen J, Boeing H, Pischon T, Weikert C, Olsen A, Tjonneland A, Johnsen SP, Jensen MK, Quiros JR, Gonzalez Svatetz CA, Sanchez Perez M-J, Larranaga N, Navarro Sanchez C, Moreno Iribas C, Bingham S, Khaw K-T, Wareham N, Key T, Roddam A, Trichopoulou A, Benetou V, Trichopoulos D, Masala G, Sieri S, Tumino R, Sacerdote C, Mattiello A, Verschuren WMM, Bueno-de-Mesquita HB, Grobbee DE, van der Schouw YT, Melander O, Hallmans G, Wennberg P, Lund E, Kumle M, Skeie G, Ferrari P, Slimani N, Norat T, Riboli Eet al., 2007, EPIC-Heart:: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 22, Pages: 129-141, ISSN: 0393-2990

• Author Web Link
• Cite
• Citations: 89

Nagel G, Linseisen J, Boshuizen HC, Pera G, Del Giudice G, Westert GP, Bueno-de-Mesquita HB, Allen NE, Key TJ, Numans ME, Peeters PH, Sieri S, Siman H, Berglund G, Hallmans G, Stenling R, Martinez C, Arriola L, Barricarte A, Chirlaque MD, Quiros JR, Vineis P, Masala G, Palli D, Panico S, Tumino R, Bingham S, Boeing H, Bergmann MM, Overvad K, Boutron-Ruault M-C, Clavel-Chapelon F, Olsen A, Tjonneland A, Trichopoulou A, Bamia C, Soukara S, Sabourin J-C, Carneiro F, Slimani N, Jenab M, Norat T, Riboli E, González CAet al., 2007, Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)., Int J Epidemiol, Vol: 36, Pages: 66-76, ISSN: 0300-5771

OBJECTIVES: To evaluate the association of socioeconomic position with adenocarcinoma of the oesophagus and stomach. METHODS: The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort comprises about 520 000 participants mostly aged 35-70 years. Information on diet and lifestyle was collected at recruitment. After an average follow-up of 6.5 years, 268 cases with adenocarcinoma of the stomach and 56 of the oesophagus were confirmed. We examined the effect of socioeconomic position on cancer risk by means of educational data and a computed Relative Index of Inequality (RII). In a nested case-control study, adjustment for Helicobacter pylori (H. pylori) infection was performed. RESULTS: Higher education was significantly associated with a reduced risk of gastric cancer [vs lowest level of education, hazard ratio (HR): 0.64, 95% Confidence intervals (CI): 0.43-0.98]. This effect was more pronounced for cancer of the cardia (HR: 0.42, 95% CI: 0.20-0.89) as compared to non-cardia gastric cancer (HR: 0.66, 95% CI: 0.36-1.22). Additionally, the inverse association of educational level and gastric cancer was stronger for cases with intestinal (extreme categories, HR: 0.13, 95% CI: 0.04-0.44) rather than diffuse histological subtype (extreme categories, HR: 0.71 95% CI: 0.37-1.40). In the nested case-control study, inverse but statistically non-significant associations were found after additional adjustment for H. pylori infection [highest vs lowest level of education: Odds ratio (OR) 0.53, 95% CI: 0.24-1.18]. Educational level was non-significantly, inversely associated with carcinoma of the oesophagus. CONCLUSION: A higher socioeconomic position was associated with a reduced risk of gastric adenocarcinoma, which was strongest for cardia cancer or intestinal histological subtype, suggesting different risk profiles according to educational level. These effects appear to be explained only partially by established risk factors.

• Abstract
• Author Web Link
• Cite

Norat T, Dossus L, Rinaldi S, Overvad K, Gronbaek H, Tjonneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault MC, Boeing H, Lahmann PH, Linseisen J, Nagel G, Trichopoulou A, Trichopoulos D, Kalapothaki V, Sieri S, Palli D, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Peeters PHM, van Gils CH, Agudo A, Amiano P, Ardanoz E, Martinez C, Quiros R, Tormo MJ, Bingham S, Key TJ, Allen NE, Ferrari P, Slimani N, Riboli E, Kaaks Ret al., 2007, Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 61, Pages: 91-98, ISSN: 0954-3007

• Author Web Link
• Cite
• Citations: 115

Rohrmann S, Linseisen J, Boshuizen HC, Whittaker J, Agudo A, Vineis P, Boffetta P, Jensen MK, Olsen A, Overvad K, Tjonneland A, Boutron-Ruault M-C, Clavel-Chapelon F, Bergmann MM, Boeing H, Allen N, Key T, Bingham S, Khaw K-T, Kyriazi G, Soukara S, Trichopoulou A, Panico S, Palli D, Sieri S, Tumino R, Peeters PHM, Bueno-de-Mesquita HB, Buchner FL, Gram IT, Lund E, Ardanaz E, Chirlaque M-D, Dorronsoro M, Sanchez Perez M-J, Quiros JR, Berglund G, Janzon L, Rasmuson T, Weinehall L, Ferrari P, Jenab M, Norat T, Riboli Eet al., 2006, Ethanol intake and risk of lung cancer in the European prospective investigation into cancer and nutrition (EPIC), AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 164, Pages: 1103-1114, ISSN: 0002-9262

• Author Web Link
• Cite
• Citations: 27

Rohrmann S, Linseisen J, Boshuizen HC, Whittaker J, Agudo A, Vineis P, Boffetta P, Jensen MK, Olsen A, Overvad K, Tjønneland A, Boutron-Ruault M-C, Clavel-Chapelon F, Bergmann MM, Boeing H, Allen N, Key T, Bingham S, Khaw K-T, Kyriazi G, Soukara S, Trichopoulou A, Panico S, Palli D, Sieri S, Tumino R, Peeters PHM, Bueno-de-Mesquita HB, Büchner FL, Gram IT, Lund E, Ardanaz E, Chirlaque M-D, Dorronsoro M, Pérez M-JS, Quirós JR, Berglund G, Janzon L, Rasmuson T, Weinehall L, Ferrari P, Jenab M, Norat T, Riboli Eet al., 2006, Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)., Am J Epidemiol, Vol: 164, Pages: 1103-1114, ISSN: 0002-9262

Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.

• Abstract
• Author Web Link
• Cite

Agudo A, Sala N, Pera G, Capella G, Berenguer A, Garcia N, Palli D, Boeing H, Del Giudice G, Saieva C, Carneiro F, Berrino F, Sacerdote C, Tumino R, Panico S, Berglund G, Siman H, Stenling R, Hallmans G, Martinez C, Bilbao R, Barricarte A, Navarro C, Quiros JR, Allen N, Key T, Bingham S, Khaw K-T, Linseisen J, Nagel G, Overvad K, Tjonneland A, Olsen A, Bueno-de-Mesquita HB, Boshuizen HC, Peeters PH, Numans ME, Clavel-Chapelon F, Boutron-Ruault M-C, Trichopoulou A, Lund E, Offerhaus J, Jenab M, Ferrari P, Norat T, Riboli E, Gonzalez CAet al., 2006, Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 15, Pages: 2427-2434, ISSN: 1055-9965

• Author Web Link
• Cite
• Citations: 52