DrTeresaNorat

Crowe FL, Key TJ, Allen NE, Appleby PN, Overvad K, Gronbaek H, Tjonneland A, Halkjaer J, Dossus L, Boeing H, Kroger J, Trichopoulou A, Zylis D, Trichopoulos D, Boutron-Ruault MC, de Lauzon-Guillain B, Clavel-Chapelon F, Palli D, Berrino F, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, van Gils CH, Peeters PH, Gram IT, Rodriguez L, Jakszyn P, Molina-Montes E, Navarro C, Barricarte A, Larranaga N, Khaw KT, Rodwell S, Rinaldi S, Slimani N, Norat T, Gallo V, Riboli E, Kaaks Ret al., 2011, A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC), Vol: 38, Pages: 194-202, ISSN: 1464-5033

BACKGROUND: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. AIM: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. SUBJECTS AND METHODS: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). RESULTS: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). CONCLUSION: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.

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Crowe FL, Roddam AW, Key TJ, Appleby PN, Overvad K, Jakobsen MU, Tjonneland A, Hansen L, Boeing H, Weikert C, Linseisen J, Kaaks R, Trichopoulou A, Misirli G, Lagiou P, Sacerdote C, Pala V, Palli D, Tumino R, Panico S, Bueno-de-Mesquita HB, Boer J, van Gils CH, Beulens JW, Barricarte A, Rodriguez L, Larranaga N, Sanchez MJ, Tormo MJ, Buckland G, Lund E, Hedblad B, Melander O, Jansson JH, Wennberg P, Wareham NJ, Slimani N, Romieu I, Jenab M, Danesh J, Gallo V, Norat T, Riboli Eet al., 2011, Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study, Vol: 32, Pages: 1235-1243, ISSN: 1522-9645

AIMS: A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. METHODS AND RESULTS: After an average of 8.4 years of follow-up, there were 1636 deaths from IHD among 313 074 men and women without previous myocardial infarction or stroke from eight European countries. Participants consuming at least eight portions (80 g each) of fruits and vegetables a day had a 22% lower risk of fatal IHD [relative risk (RR) = 0.78, 95% confidence interval (CI): 0.65-0.95] compared with those consuming fewer than three portions a day. After calibration of fruit and vegetable intake to account for differences in dietary assessment between the participating centres, a one portion (80 g) increment in fruit and vegetable intake was associated with a 4% lower risk of fatal IHD (RR = 0.96, 95% CI: 0.92-1.00, P for trend = 0.033). CONCLUSION: Results from this large observational study suggest that a higher intake of fruits and vegetables is associated with a reduced risk of IHD mortality. Whether this association is causal and, if so, the biological mechanism(s) by which fruits and vegetables operate to lower IHD risks remains unclear.

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Baltar VT, Xun WW, Chuang SC, Relton C, Ueland PM, Vollset SE, Midttun O, Johansson M, Slimani N, Jenab M, Clavel-Chapelon F, Boutron-Ruault MC, Fagherazzi G, Kaaks R, Rohrmann S, Boeing H, Weikert C, Bueno-de-Mesquita HB, Boshuizen HC, van Gils CH, Peeters PH, Agudo A, Barricarte A, Navarro C, Rodriguez L, Castano JM, Larranaga N, Perez MJ, Khaw KT, Wareham N, Allen NE, Crowe F, Gallo V, Norat T, Tagliabue G, Masala G, Panico S, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Bamia C, Rasmuson T, Hallmans G, Roswall N, Tjonneland A, Riboli E, Brennan P, Vineis Pet al., 2011, Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort, Vol: 20, Pages: 869-875, ISSN: 1538-7755

BACKGROUND: Several countries are discussing new legislation regarding the ban on smoking in public places, based on the growing evidence of the hazards of secondhand smoke (SHS) exposure. The objective of the present study is to quantitatively assess the relationship between smoking, SHS, and serum cotinine levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: From a study on lung cancer in the EPIC cohort, questionnaire information on smoking was collected at enrolment, and cotinine was measured in serum. Three statistical models were applied by using samples available in a cross-section design: (i) cotinine levels by categories combining smoking and SHS (n = 859); (ii) the effect of hours of passive smoking exposure in nonsmokers only (n = 107); (iii) the effect of the number of cigarettes consumed per day in current smokers only (n = 832). All models were adjusted for country, sex, age, and body mass index. RESULTS: Among nonsmokers, passive smokers presented significant differences in cotinine compared with nonexposed, with a marked (but not significant) difference among former-smokers. A one hour per day increment of SHS gave rise to a significant 2.58 nmol/L (0.45 ng/mL) increase in mean serum cotinine (P < 0.001). In current smokers, a one cigarette per day increment gave rise to a significant 22.44 nmol/L (3.95 ng/mL) increase in cotinine mean (P < 0.001). CONCLUSIONS: There is clear evidence that not only tobacco smoking but also involuntary exposure increases cotinine levels. IMPACT: This study strengthens the evidence for the benefits of a smoking ban in public places.

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Bakken K, Fournier A, Lund E, Waaseth M, Dumeaux V, Clavel-Chapelon F, Fabre A, Hemon B, Rinaldi S, Chajes V, Slimani N, Allen NE, Reeves GK, Bingham S, Khaw KT, Olsen A, Tjonneland A, Rodriguez L, Sanchez MJ, Etxezarreta PA, Ardanaz E, Tormo MJ, Peeters PH, van Gils CH, Steffen A, Schulz M, Chang-Claude J, Kaaks R, Tumino R, Gallo V, Norat T, Riboli E, Panico S, Masala G, Gonzalez CA, Berrino Fet al., 2011, Menopausal hormone therapy and breast cancer risk: impact of different treatments. The European Prospective Investigation into Cancer and Nutrition, Vol: 128, Pages: 144-156, ISSN: 1097-0215

Menopausal hormone therapy (MHT) is characterized by use of different constituents, regimens and routes of administration. We investigated the association between the use of different types of MHT and breast cancer risk in the EPIC cohort study. The analysis is based on data from 133,744 postmenopausal women. Approximately 133,744 postmenopausal women contributed to this analysis. Information on MHT was derived from country-specific self-administered questionnaires with a single baseline assessment. Incident breast cancers were identified through population cancer registries or by active follow-up (mean: 8.6 yr). Overall relative risks (RR) and 95% confidence interval (CI) were derived from country-specific Cox proportional hazard models estimates. A total of 4312 primary breast cancers were diagnosed during 1,153,747 person-years of follow-up. Compared with MHT never users, breast cancer risk was higher among current users of estrogen only (RR: 1.42, 95% CI 1.23-1.64) and higher still among current users of combined MHT (RR: 1.77, 95% CI 1.40-2.24; p = 0.02 for combined vs. estrogen-only). Continuous combined regimens conferred a 43% (95% CI: 19-72%) greater risk compared with sequential regimens. There was no significant difference between progesterone and testosterone derivatives in sequential regimens. There was no significant variation in risk linked to the estrogenic component of MHT, neither for oral vs. cutaneous administration nor for estradiol compounds vs. conjugated equine estrogens. Estrogen-only and combined MHT uses were associated with increased breast cancer risk. Continuous combined preparations were associated with the highest risk. Further studies are needed to disentangle the effects of the regimen and the progestin component.

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Timofeeva MN, McKay JD, Smith GD, Johansson M, Byrnes GB, Chabrier A, Relton C, Ueland PM, Vollset SE, Midttun O, Nygard O, Slimani N, Romieu I, Clavel-Chapelon F, Boutron-Ruault MC, Fagherazzi G, Kaaks R, Teucher B, Boeing H, Weikert C, Bueno-de-Mesquita HB, van Gils C, Peeters PH, Agudo A, Barricarte A, Huerta JM, Rodriguez L, Sanchez MJ, Larranaga N, Khaw KT, Wareham N, Allen NE, Travis RC, Gallo V, Norat T, Krogh V, Masala G, Panico S, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Trichopoulos D, Rasmuson T, Hallmans G, Riboli E, Vineis P, Brennan Pet al., 2011, Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC, Vol: 20, Pages: 2250-2261, ISSN: 1538-7755

BACKGROUNDS: Multiple polymorphisms affecting smoking behavior have been identified through genome-wide association studies. Circulating levels of the nicotine metabolite cotinine is a marker of recent smoking exposure. Hence, genetic variants influencing smoking behavior are expected to be associated with cotinine levels. METHODS: We conducted an analysis in a lung cancer case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We investigated the effects of single-nucleotide polymorphisms (SNP) previously associated with smoking behavior on (i) circulating cotinine and (ii) lung cancer risk. A total of 894 cases and 1,805 controls were analyzed for cotinine and genotyped for 10 polymorphisms on 7p14, 8p11, 10q23, 15q25, and 19q13. RESULTS: Two variants in the nicotinic acetylcholine receptor subunit genes CHRNA5 and CHRNA3 on 15q25, rs16969968 and rs578776, were associated with cotinine (P = 0.001 and 0.03, respectively) in current smokers and with lung cancer risk (P < 0.001 and P = 0.001, respectively). Two 19q13 variants, rs7937 and rs4105144, were associated with increased cotinine (P = 0.003 and P < 0.001, respectively) but decreased lung cancer risk (P = 0.01 for both, after adjusting for cotinine). Variants in 7p14, 8p11, and 10q23 were not associated with cotinine or lung cancer risk. CONCLUSIONS: 15q25 and 19q13 SNPs were associated with circulating cotinine. The directions of association for 15q25 variants with cotinine were in accordance with that expected of lung cancer risk, whereas SNPs on 19q13 displayed contrasting associations of cotinine and lung cancer that require further investigation. IMPACT: This study is the largest to date investigating the effects of polymorphisms affecting smoking behavior on lung cancer risk using circulating cotinine measures as proxies for recent smoking behavior.

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Dossus L, Rinaldi S, Becker S, Lukanova A, Tjonneland A, Olsen A, Stegger J, Overvad K, Chabbert-Buffet N, Jimenez-Corona A, Clavel-Chapelon F, Rohrmann S, Teucher B, Boeing H, Schuetze M, Trichopoulou A, Benetou V, Lagiou P, Palli D, Berrino F, Panico S, Tumino R, Sacerdote C, Redondo M-L, Travier N, Sanchez M-J, Altzibar JM, Chirlaque M-D, Ardanaz E, Bueno-de-Mesquita HB, van Duijnhoven FJB, Onland-Moret NC, Peeters PHM, Hallmans G, Lundin E, Khaw K-T, Wareham N, Allen N, Key TJ, Slimani N, Hainaut P, Romaguera D, Norat T, Riboli E, Kaaks Ret al., 2010, Obesity, inflammatory markers, and endometrial cancer risk: a prospective case-control study, ENDOCRINE-RELATED CANCER, Vol: 17, Pages: 1007-1019, ISSN: 1351-0088

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• Citations: 122

Tsilidis KK, Allen NE, Key TJ, Bakken K, Lund E, Berrino F, Fournier A, Olsen A, Tjonneland A, Overvad K, Boutron-Ruault M-C, Clavel-Chapelon F, Byrnes G, Chajes V, Rinaldi S, Chang-Claude J, Kaaks R, Bergmann M, Boeing H, Koumantaki Y, Stasinopoulou G, Trichopoulou A, Palli D, Tagliabue G, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, van Duijnhoven FJB, van Gils CH, Peeters PHM, Rodriguez L, Gonzalez CA, Sanchez M-J, Chirlaque M-D, Barricarte A, Dorronsoro M, Borgquist S, Manjer J, van Guelpen B, Hallmans G, Rodwell SA, Khaw K-T, Norat T, Romaguera D, Riboli Eet al., 2010, Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition, BRITISH JOURNAL OF CANCER, Vol: 103, Pages: 1755-1759, ISSN: 0007-0920

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• Citations: 40

Vergnaud AC, Norat T, Romaguera D, Peeters PHMet al., 2010, Meat intake's influence on body fatness cannot be assessed without measurement of body Reply, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 92, Pages: 1275-1276, ISSN: 0002-9165

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• Citations: 2

Eussen SJPM, Vollset SE, Hustad S, Midttun O, Meyer K, Fredriksen A, Ueland PM, Jenab M, Slimani N, Boffetta P, Overvad K, Thorlacius-Ussing O, Tjonneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault M-C, Morois S, Weikert C, Pischon T, Linseisen J, Kaaks R, Trichopoulou A, Zilis D, Katsoulis M, Palli D, Pala V, Vineis P, Tumino R, Panico S, Peeters PHM, Bueno-de-Mesquita HB, van Duijnhoven FJB, Skeie G, Munoz X, Martinez C, Dorronsoro M, Ardanaz E, Navarro C, Rodriguez L, VanGuelpen B, Palmqvist R, Manjer J, Ericson U, Bingham S, Khaw K-T, Norat T, Riboli Eet al., 2010, Plasma Vitamins B2, B6, and B12, and Related Genetic Variants as Predictors of Colorectal Cancer Risk, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 19, Pages: 2549-2561, ISSN: 1055-9965

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• Citations: 55

Romaguera D, Norat T, Vergnaud A-C, Mouw T, May AM, Agudo A, Buckland G, Slimani N, Rinaldi S, Couto E, Clavel-Chapelon F, Boutron-Ruault M-C, Cottet V, Rohrmann S, Teucher B, Bergmann M, Boeing H, Tjonneland A, Halkjaer J, Jakobsen MU, Dahm CC, Travier N, Rodriguez L, Jose Sanchez M, Amiano P, Barricarte A, Maria Huerta J, Luan J, Wareham N, Key TJ, Spencer EA, Orfanos P, Naska A, Trichopoulou A, Palli D, Agnoli C, Mattiello A, Tumino R, Vineis P, Bueno-de-Mesquita HB, Buechner FL, Manjer J, Wirfalt E, Johansson I, Hellstrom V, Lund E, Braaten T, Engeset D, Odysseos A, Riboli E, Peeters PHMet al., 2010, Mediterranean dietary patterns and prospective weight change in participants of the EPIC-PANACEA project, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 92, Pages: 912-921, ISSN: 0002-9165

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• Citations: 142

Aleksandrova K, Jenab M, Boeing H, Jansen E, Bueno-de-Mesquita HB, Rinaldi S, Riboli E, Overvad K, Dahm CC, Olsen A, Tjonneland A, Boutron-Ruault M-C, Clavel-Chapelon F, Morois S, Palli D, Krogh V, Tumino R, Vineis P, Panico S, Kaaks R, Rohrmann S, Trichopoulou A, Lagiou P, Trichopoulos D, van Duijnhoven FJB, Leufkens AM, Peeters PH, Rodriguez L, Bonet C, Sanchez M-J, Dorronsoro M, Navarro C, Barricarte A, Palmqvist R, Hallmans G, Khaw K-T, Wareham N, Allen NE, Spencer E, Romaguera D, Norat T, Pischon Tet al., 2010, Circulating C-Reactive Protein Concentrations and Risks of Colon and Rectal Cancer: A Nested Case-Control Study Within the European Prospective Investigation into Cancer and Nutrition, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 172, Pages: 407-418, ISSN: 0002-9262

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• Citations: 95

Vergnaud A-C, Norat T, Romaguera D, Mouw T, May AM, Travier N, Luan J, Wareham N, Slimani N, Rinaldi S, Couto E, Clavel-Chapelon F, Boutron-Ruault M-C, Cottet V, Palli D, Agnoli C, Panico S, Tumino R, Vineis P, Agudo A, Rodriguez L, Jose Sanchez M, Amiano P, Barricarte A, Maria Huerta J, Key TJ, Spencer EA, Bueno-de-Mesquita B, Buchner FL, Orfanos P, Naska A, Trichopoulou A, Rohrmann S, Hermann S, Boeing H, Buijsse B, Johansson I, Hellstrom V, Manjer J, Wirfalt E, Jakobsen MU, Overvad K, Tjonneland A, Halkjaer J, Lund E, Braaten T, Engeset D, Odysseos A, Riboli E, Peeters PHMet al., 2010, Meat consumption and prospective weight change in participants of the EPIC-PANACEA study, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 92, Pages: 398-407, ISSN: 0002-9165

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• Citations: 146

Druesne-Pecollo N, Latino-Martel P, Norat T, Barrandon E, Bertrais S, Galan P, Hercberg Set al., 2010, Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials, INTERNATIONAL JOURNAL OF CANCER, Vol: 127, Pages: 172-184, ISSN: 0020-7136

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• Citations: 186

Freisling H, Fahey MT, Moska A, Ocke MC, Ferrari P, Jenab M, Norat T, Naska A, Welch AA, Navarro C, Schulz M, Wirfaelt E, Casagrande C, Amiano P, Ardanaz E, Parr C, Engeset D, Grioni S, Sera F, Bueno-de-Mesquita B, van der Schouw YT, Touvier M, Boutron-Ruault M-C, Halkjaer J, Dahm CC, Khaw K-T, Crowe F, Linseisen J, Kroeger J, Huybrechts I, Deharveng G, Manjer J, Agren A, Trichopoulou A, Tsiotas K, Riboli E, Bingham S, Slimani Net al., 2010, Region-Specific Nutrient Intake Patterns Exhibit a Geographical Gradient within and between European Countries, JOURNAL OF NUTRITION, Vol: 140, Pages: 1280-1286, ISSN: 0022-3166

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• Citations: 107

Johansson M, Relton C, Ueland PM, Vollset SE, Midttun Ø, Nygård O, Slimani N, Boffetta P, Jenab M, Clavel-Chapelon F, Boutron-Ruault MC, Fagherazzi G, Kaaks R, Rohrmann S, Boeing H, Weikert C, Bueno-de-Mesquita HB, Ros MM, van Gils CH, Peeters PH, Agudo A, Barricarte A, Navarro C, Rodríguez L, Sánchez MJ, Larrañaga N, Khaw KT, Wareham N, Allen NE, Crowe F, Gallo V, Norat T, Krogh V, Masala G, Panico S, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Trichopoulos D, Rasmuson T, Hallmans G, Riboli E, Vineis P, Brennan Pet al., 2010, Serum B vitamin levels and risk of lung cancer., JAMA, Vol: 303, Pages: 2377-2385, ISSN: 1538-3598

B vitamins and factors related to 1-carbon metabolism help to maintain DNA integrity and regulate gene expression and may affect cancer risk.

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Fedirko V, Riboli E, Rinaldi S, Norat T, Bueno-de-Mesquita HB, van Duijnhoven FJB, Pischon T, Jansen EHJM, Jenab Met al., 2010, Pre-diagnostic circulating parathyroid hormone concentration and colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 21st Meeting of the European-Association-for-Cancer-Research, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 16-16, ISSN: 1359-6349

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Lahmann PH, Cust AE, Friedenreich CM, Schulz M, Lukanova A, Kaaks R, Lundin E, Tjonneland A, Halkjaer J, Severinsen MT, Overvad K, Fournier A, Chabbert-Buffet N, Clavel-Chapelon F, Dossus L, Pischon T, Boeing H, Trichopoulou A, Lagiou P, Naska A, Palli D, Grioni S, Mattiello A, Tumino R, Sacerdote C, Redondo M-L, Jakszyn P, Sanchez M-J, Tormo M-J, Ardanaz E, Arriola L, Manjer J, Jirstrom K, Bueno-de-Mesquita HB, May AM, Peeters PHM, Onland-Moret NC, Bingham S, Khaw K-T, Allen NE, Spencer E, Rinaldi S, Slimani N, Chajes V, Michaud D, Norat T, Riboli Eet al., 2010, Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 126, Pages: 2404-2415, ISSN: 0020-7136

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• Citations: 57

Tailor AM, Peeters PHM, Norat T, Vineis P, Romaguera Det al., 2010, An update on the prevalence of the metabolic syndrome in children and adolescents, INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY, Vol: 5, Pages: 202-213, ISSN: 1747-7166

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• Citations: 96

Maria Huerta J, Navarro C, Chirlaque M-D, Tormo M-J, Steindorf K, Buckland G, Carneiro F, Johnsen NF, Overvad K, Stegger J, Tjonneland A, Boutron-Ruault M-C, Clavel-Chapelon F, Morois S, Boeing H, Kaaks R, Rohrmann S, Vigl M, Lagiou P, Trichopoulos D, Trichopoulou A, Bueno-de-Mesquita HB, Monninkhof EM, Numans ME, Peeters PH, Mattiello A, Pala V, Palli D, Tumino R, Vineis P, Agudo A, Ardanaz E, Arriola L, Molina-Montes E, Rodriguez L, Lindkvist B, Manjer J, Stenling R, Lund E, Crowe FL, Key TJ, Khaw K-T, Wareham NJ, Jenab M, Norat T, Romaguera D, Riboli E, Gonzalez CAet al., 2010, Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort, CANCER CAUSES & CONTROL, Vol: 21, Pages: 657-669, ISSN: 0957-5243

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• Citations: 47

Eussen SJPM, Vollset SE, Igland J, Meyer K, Fredriksen A, Ueland PM, Jenab M, Slimani N, Boffetta P, Overvad K, Tjonneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault M-C, Morois S, Weikert C, Pischon T, Linseisen J, Kaaks R, Trichopoulou A, Zilis D, Katsoulis M, Palli D, Berrino F, Vineis P, Tumino R, Panico S, Peeters PHM, Bueno-de-Mesquita HB, van Duijnhoven FJB, Gram IT, Skeie G, Lund E, Gonzalez CA, Martinez C, Dorronsoro M, Ardanaz E, Navarro C, Rodriguez L, Van Guelpen B, Palmqvist R, Manjer J, Ericson U, Bingham S, Khaw K-T, Norat T, Riboli Eet al., 2010, Plasma Folate, Related Genetic Variants, and Colorectal Cancer Risk in EPIC, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 19, Pages: 1328-1340, ISSN: 1055-9965

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• Citations: 65

Latino-Martel P, Chan DSM, Druesne-Pecollo N, Barrandon E, Hercberg S, Norat Tet al., 2010, Maternal Alcohol Consumption during Pregnancy and Risk of Childhood Leukemia: Systematic Review and Meta-analysis, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 19, Pages: 1238-1260, ISSN: 1055-9965

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• Citations: 64

Boffetta P, Couto E, Wichmann J, Ferrari P, Trichopoulos D, Bueno-de-Mesquita HB, van Duijnhoven FJB, Buchner FL, Key T, Boeing H, Noethlings U, Linseisen J, Gonzalez CA, Overvad K, Nielsen MRS, Tjonneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault M-C, Morois S, Lagiou P, Naska A, Benetou V, Kaaks R, Rohrmann S, Panico S, Sieri S, Vineis P, Palli D, van Gils CH, Peeters PH, Lund E, Brustad M, Engeset D, Maria Huerta J, Rodriguez L, Sanchez M-J, Dorronsoro M, Barricarte A, Hallmans G, Johansson I, Manjer J, Sonestedt E, Allen NE, Bingham S, Khaw K-T, Slimani N, Jenab M, Mouw T, Norat T, Riboli E, Trichopoulou Aet al., 2010, Fruit and Vegetable Intake and Overall Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC), JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 102, Pages: 529-537, ISSN: 0027-8874

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• Citations: 274

Rinaldi S, Cleveland R, Norat T, Biessy C, Rohrmann S, Linseisen J, Boeing H, Pischon T, Panico S, Agnoli C, Palli D, Tumino R, Vineis P, Peeters PHM, van Gils CH, Bueno-de-Mesquita BH, Vrieling A, Allen NE, Roddam A, Bingham S, Khaw K-T, Manjer J, Borgquist S, Dumeaux V, Gram IT, Lund E, Trichopoulou A, Makrygiannis G, Benetou V, Molina E, Donate Suarez I, Barricarte Gurrea A, Gonzalez CA, Tormo M-J, Altzibar JM, Olsen A, Tjonneland A, Gronbaek H, Overvad K, Clavel-Chapelon F, Boutron-Ruault M-C, Morois S, Slimani N, Boffetta P, Jenab M, Riboli E, Kaaks Ret al., 2010, Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies, INTERNATIONAL JOURNAL OF CANCER, Vol: 126, Pages: 1702-1715, ISSN: 0020-7136

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• Citations: 173

Buchner FL, Bueno-de-Mesquita HB, Linseisen J, Boshuizen HC, Kiemeney LALM, Ros MM, Overvad K, Hansen L, Tjonneland A, Raaschou-Nielsen O, Clavel-Chapelon F, Boutron-Ruault M-C, Touillaud M, Kaaks R, Rohrmann S, Boeing H, Noethlings U, Trichopoulou A, Zylis D, Dilis V, Palli D, Sieri S, Vineis P, Tumino R, Panico S, Peeters PHM, van Gils CH, Lund E, Gram IT, Braaten T, Martinez C, Agudo A, Arriola L, Ardanaz E, Navarro C, Rodriguez L, Manjer J, Wirfalt E, Hallmans G, Rasmuson T, Key TJ, Roddam AW, Bingham S, Khaw K-T, Slimani N, Bofetta P, Byrnes G, Norat T, Michaud D, Riboli Eet al., 2010, Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC), Cancer Causes & Control, Vol: 21, Pages: 357-371, ISSN: 1573-7225

Objective To examine the association between fruit andvegetable consumption and risk of different histologicalsubtypes of lung cancer among participants of the EuropeanProspective Investigation into Cancer and Nutritionstudy.Methods Multivariable Cox proportional hazard modelswere used to analyze the data. A calibration study in asubsample was used to reduce dietary measurement errors.Results During a mean follow-up of 8.7 years, 1,830incident cases of lung cancer (574 adenocarcinoma, 286small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previousconclusions, we found that after calibration a 100 g/dayincrease in fruit and vegetables consumption was associatedwith a reduced lung cancer risk (HR 0.94; 95% CI0.89–0.99). This was also seen among current smokers (HR0.93; 95% CI 0.90–0.97). Risks of squamous cell carcinomasin current smokers were reduced for an increase of100 g/day of fruit and vegetables combined (HR 0.85; 95%CI 0.76–0.94), while no clear effects were seen for theother histological subtypes.Conclusion We observed inverse associations betweenthe consumption of vegetables and fruits and risk of lungcancer without a clear effect on specific histologicalsubtypes of lung cancer. In current smokers, consumptionof vegetables and fruits may reduce lung cancerrisk, in particular the risk of squamous cellcarcinomas.

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Hoeft B, Linseisen J, Beckmann L, Mueller-Decker K, Canzian F, Huesing A, Kaaks R, Vogel U, Jakobsen MU, Overvad K, Hansen RD, Knueppel S, Boeing H, Trichopoulou A, Koumantaki Y, Trichopoulos D, Berrino F, Palli D, Panico S, Tumino R, Bueno-de-Mesquita HB, van Duijnhoven FJB, van Gils CH, Peeters PH, Dumeaux V, Lund E, Huerta Castano JM, Munoz X, Rodriguez L, Barricarte A, Manjer J, Jirstrom K, Van Guelpen B, Hallmans G, Spencer EA, Crowe FL, Khaw K-T, Wareham N, Morois S, Boutron-Ruault M-C, Clavel-Chapelon F, Chajes V, Jenab M, Boffetta P, Vineis P, Mouw T, Norat T, Riboli E, Nieters Aet al., 2010, Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk, CARCINOGENESIS, Vol: 31, Pages: 466-472, ISSN: 0143-3334

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• Citations: 53

Jenab M, Bueno-de-Mesquita HB, Ferrari P, van Duijnhoven FJB, Norat T, Pischon T, Jansen EHJM, Slimani N, Byrnes G, Rinaldi S, Tjonneland A, Olsen A, Overvad K, Boutron-Ruault M-C, Clavel-Chapelon F, Morois S, Kaaks R, Linseisen J, Boeing H, Bergmann MM, Trichopoulou A, Misirli G, Trichopoulos D, Berrino F, Vineis P, Panico S, Palli D, Tumino R, Ros MM, van Gils CH, Peeters PH, Brustad M, Lund E, Tormo M-J, Ardanaz E, Rodriguez L, Sanchez M-J, Dorronsoro M, Gonzalez CA, Hallmans G, Palmqvist R, Roddam A, Key TJ, Khaw K-T, Autier P, Hainaut P, Riboli Eet al., 2010, Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study, British Medical Journal, Vol: 340, ISSN: 1468-5833

Objective To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations.Design Nested case-control study.Setting The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries.Participants 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controlsMain outcome measures Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders.Results 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend <0.001). Compared with a pre-defined mid-level concentration of 25-(OH)D (50.0-75.0 nmol/l), lower levels were associated with higher colorectal cancer risk (<25.0 nmol/l: incidence rate ratio 1.32 (95% confidence interval 0.87 to 2.01); 25.0-49.9 nmol/l: 1.28 (1.05 to 1.56), and higher concentrations associated with lower risk (75.0-99.9 nmol/l: 0.88 (0.68 to 1.13); ≥100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P<0.001). Subgroup analyses showed a strong association for colon but not rectal cancer (P for heterogeneity=0.048). Greater dietary intake of calcium was associated with a lower colorectal cancer risk. Dietary vitamin D was not associated with disease risk. Findings did not vary by sex and were n

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Nagel G, Linseisen J, van Gils CH, Peeters PH, Boutron-Ruault MC, Clavel-Chapelon F, Romieu I, Tjonneland A, Olsen A, Roswall N, Witt PM, Overvad K, Rohrmann S, Kaaks R, Drogan D, Boeing H, Trichopoulou A, Stratigakou V, Zylis D, Engeset D, Lund E, Skeie G, Berrino F, Grioni S, Mattiello A, Masala G, Tumino R, Zanetti R, Ros MM, Bueno-de-Mesquita HB, Ardanaz E, Sanchez MJ, Huerta JM, Amiano P, Rodriguez L, Manjer J, Wirfalt E, Lenner P, Hallmans G, Spencer EA, Key TJ, Bingham S, Khaw KT, Rinaldi S, Slimani N, Boffetta P, Gallo V, Norat T, Riboli Eet al., 2010, Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC), Vol: 119, Pages: 753-765, ISSN: 1573-7217

So far, studies on dietary antioxidant intake, including beta-carotene, vitamin C and vitamin E, and breast cancer risk are inconclusive. Thus, we addressed this question in the European Prospective Investigation into Cancer and Nutrition. During a median follow-up time of 8.8 years, 7,502 primary invasive breast cancer cases were identified. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). All analyses were run stratified by menopausal status at recruitment and, additionally, by smoking status, alcohol intake, use of exogenous hormones and use of dietary supplements. In the multivariate analyses, dietary intake of beta-carotene, vitamin C and E was not associated with breast cancer risk in premenopausal [highest vs. lowest quintile: HR, 1.04 (95% CI, 0.85-1.27), 1.12 (0.92-1.36) and 1.11 (0.84-1.46), respectively] and postmenopausal women [0.93 (0.82-1.04), 0.98 (0.87-1.11) and 0.92 (0.77-1.11), respectively]. However, in postmenopausal women using exogenous hormones, high intake of beta-carotene [highest vs. lowest quintile; HR 0.79 (95% CI, 0.66-0.96), P (trend) 0.06] and vitamin C [0.88 (0.72-1.07), P (trend) 0.05] was associated with reduced breast cancer risk. In addition, dietary beta-carotene was associated with a decreased risk in postmenopausal women with high alcohol intake. Overall, dietary intake of beta-carotene, vitamin C and E was not related to breast cancer risk in neither pre- nor postmenopausal women. However, in subgroups of postmenopausal women, a weak protective effect between beta-carotene and vitamin E from food and breast cancer risk cannot be excluded.

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Travier N, Agudo A, May AM, Gonzalez C, Luan J, Besson H, Wareham NJ, Slimani N, Rinaldi S, Clavel-Chapelon F, Boutron-Ruault M-C, Palli D, Agnoli C, Mattiello A, Tumino R, Vineis P, Rodriguez L, Sanchez M-J, Dorronsoro M, Barricarte A, Tormo M-J, Norat T, Mouw T, Key TJ, Spencer EA, Bueno-de-Mesquita HB, Vrieling A, Orfanos P, Naska A, Trichopoulou A, Rohrmann S, Kaaks R, Bergmann MM, Boeing H, Hallmans G, Johansson I, Manjer J, Lindkvist B, Jakobsen MU, Overvad K, Tjonneland A, Halkjaer J, Lund E, Braaten T, Odysseos A, Riboli E, Peeters PHet al., 2009, Smoking and body fatness measurements: A cross-sectional analysis in the EPIC-PANACEA study, PREVENTIVE MEDICINE, Vol: 49, Pages: 365-373, ISSN: 0091-7435

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• Citations: 22

Pala V, Krogh V, Berrino F, Sieri S, Grioni S, Tjonneland A, Olsen A, Jakobsen MU, Overvad K, Clavel-Chapelon F, Boutron-Ruault M-C, Romieu I, Linseisen J, Rohrmann S, Boeing H, Steffen A, Trichopoulou A, Benetou V, Naska A, Vineis P, Tumino R, Panico S, Masala G, Agnoli C, Engeset D, Skeie G, Lund E, Ardanaz E, Navarro C, Sanchez M-J, Amiano P, Gonzalez Svatetz CA, Rodriguez L, Wirfalt E, Manjer J, Lenner P, Hallmans G, Peeters PHM, van Gils CH, Bueno-de-Mesquita HB, van Duijnhoven FJB, Key TJ, Spencer E, Bingham S, Khaw K-T, Ferrari P, Byrnes G, Rinaldi S, Norat T, Michaud DS, Riboli Eet al., 2009, Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 90, Pages: 602-612, ISSN: 0002-9165

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• Citations: 91

Romaguera D, Norat T, Mouw T, May AM, Bamia C, Slimani N, Travier N, Besson H, Luan J, Wareham N, Rinaldi S, Couto E, Clavel-Chapelon F, Boutron-Ruault M-C, Cottet V, Palli D, Agnoli C, Panico S, Tumino R, Vineis P, Agudo A, Rodriguez L, Jose Sanchez M, Amiano P, Barricarte A, Maria Huerta J, Key TJ, Spencer EA, Bueno-de-Mesquita HB, Buchner FL, Orfanos P, Naska A, Trichopoulou A, Rohrmann S, Kaaks R, Bergmann M, Boeing H, Johansson I, Hellstrom V, Manjer J, Wirfalt E, Jacobsen MU, Overvad K, Tjonneland A, Halkjaer J, Lund E, Braaten T, Engeset D, Odysseos A, Riboli E, Peeters PHMet al., 2009, Adherence to the Mediterranean Diet Is Associated with Lower Abdominal Adiposity in European Men and Women, JOURNAL OF NUTRITION, Vol: 139, Pages: 1728-1737, ISSN: 0022-3166

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• Citations: 126