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@article{Aune:2018:10.1016/j.numecd.2018.07.005,
author = {Aune, D and Schlesinger, S and Neuenschwander, M and Feng, T and Janszky, I and Norat, T and Riboli, E},
doi = {10.1016/j.numecd.2018.07.005},
journal = {Nutrition, Metabolism and Cardiovascular Diseases},
pages = {1081--1091},
title = {Diabetes mellitus, blood glucose and the risk of heart failure: A systematic review and meta-analysis of prospective studies},
url = {http://dx.doi.org/10.1016/j.numecd.2018.07.005},
volume = {28},
year = {2018}
}

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TY  - JOUR
AB  - BACKGROUND AND AIM: The strength of the association between diabetes and risk of heart failure has differed between previous studies and the available studies have not been summarized in a meta-analysis. We therefore quantified the association between diabetes and blood glucose and heart failure in a systematic review and meta-analysis. METHODS AND RESULTS: PubMed and Embase databases were searched up to May 3rd 2018. Prospective studies on diabetes mellitus or blood glucose and heart failure risk were included. A random effects model was used to calculate summary relative risks (RRs) and 95% confidence intervals (CIs). Seventy seven studies were included. Among the population-based prospective studies, the summary RR for individuals with diabetes vs. no diabetes was 2.06 (95% CIs: 1.73-2.46, I2 = 99.8%, n = 30 studies, 401495 cases, 21416780 participants). The summary RR was 1.23 (95% CI: 1.15-1.32, I2 = 78.2%, n = 10, 5344 cases, 91758 participants) per 20 mg/dl increase in blood glucose and there was evidence of a J-shaped association with nadir around 90 mg/dl and increased risk even within the pre-diabetic blood glucose range. Among the patient-based studies the summary RR was 1.69 (95% CI: 1.57-1.81, I2 = 85.5%, pheterogeneity<0.0001) for diabetes vs. no diabetes (n = 41, 100284 cases and >613925 participants) and 1.25 (95% CI: 0.89-1.75, I2 = 95.6%, pheterogeneity<0.0001) per 20 mg/dl increase in blood glucose (1016 cases, 34309 participants, n = 2). In the analyses of diabetes and heart failure there was low or no heterogeneity among the population-based studies that adjusted for alcohol intake and physical activity and among the patient-based studies there was no heterogeneity among studies with ≥10 years follow-up. CONCLUSIONS: These results suggest that individuals with diabetes are at an increased risk of developing heart failure and there is eviden
AU  - Aune,D
AU  - Schlesinger,S
AU  - Neuenschwander,M
AU  - Feng,T
AU  - Janszky,I
AU  - Norat,T
AU  - Riboli,E
DO  - 10.1016/j.numecd.2018.07.005
EP  - 1091
PY  - 2018///
SN  - 0939-4753
SP  - 1081
TI  - Diabetes mellitus, blood glucose and the risk of heart failure: A systematic review and meta-analysis of prospective studies
T2  - Nutrition, Metabolism and Cardiovascular Diseases
UR  - http://dx.doi.org/10.1016/j.numecd.2018.07.005
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30318112
UR  - http://hdl.handle.net/10044/1/63591
VL  - 28
ER  -

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