Imperial College London
Dr Teresa Norat

DrTeresaNorat

Faculty of Medicine, School of Public Health

Academic Visitor
 
 
 
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Contact

 

+44 (0)20 7594 3454t.norat

 
 
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Location

 

509Variety Club WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aune:2020:10.1007/s00394-019-01967-w,
author = {Aune, D and Sen, A and Norat, T and Riboli, E},
doi = {10.1007/s00394-019-01967-w},
journal = {European Journal of Nutrition},
pages = {421--432},
title = {Dietary fibre intake and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies},
url = {http://dx.doi.org/10.1007/s00394-019-01967-w},
volume = {59},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: A high intake of dietary fibre has been associated with a reduced risk of diverticular disease in several studies; however, the dose-response relationship between fibre intake and diverticular disease risk has varied, and the available studies have not been summarised in a meta-analysis. We conducted a systematic review and meta-analysis of prospective cohort studies to clarify the association between dietary fibre intake, fibre subtypes, and the risk of diverticular disease. METHODS: PubMed and Embase databases were searched up to August 9th 2018. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects model and nonlinear associations were modelled using fractional polynomial models. RESULTS: Five prospective cohort studies with 19,282 cases and 865,829 participants were included in the analysis of dietary fibre and diverticular disease risk. The summary RR was 0.74 (95% CI 0.71-0.78, I2 = 0%) per 10 g/day. There was no evidence of a nonlinear association between dietary fibre intake and diverticular disease risk, pnonlinearity = 0.35, and there was a 23%, 41% and 58% reduction in risk for an intake of 20, 30, and 40 g/day, respectively, compared to 7.5 g/day. There was no evidence of publication bias with Egger's test, p = 0.58 and the association persisted in subgroup and sensitivity analyses. The summary RR per 10 g/day was 0.74 (95% CI 0.67-0.81, I2 = 60%, n = 4) for cereal fibre, 0.56 (95% CI 0.37-0.84, I2 = 73%, n = 2) for fruit fibre, and 0.80 (95% CI 0.45-1.44, I2 = 87%, n = 2) for vegetable fibre. CONCLUSIONS: These results suggest that a high fibre intake may reduce the risk of diverticular disease and individuals consuming 30 g of fibre per day have a 41% reduction in risk compared to persons with a low fibre intake. Further studies are needed on f
AU  - Aune,D
AU  - Sen,A
AU  - Norat,T
AU  - Riboli,E
DO  - 10.1007/s00394-019-01967-w
EP  - 432
PY  - 2020///
SN  - 0044-264X
SP  - 421
TI  - Dietary fibre intake and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies
T2  - European Journal of Nutrition
UR  - http://dx.doi.org/10.1007/s00394-019-01967-w
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31037341
UR  - http://hdl.handle.net/10044/1/70621
VL  - 59
ER  -
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