Imperial College London
Dr Teresa Norat

DrTeresaNorat

Faculty of Medicine, School of Public Health

Academic Visitor
 
 
 
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Contact

 

+44 (0)20 7594 3454t.norat

 
 
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Location

 

509Variety Club WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aune:2018:10.1016/j.jdiacomp.2018.02.004,
author = {Aune, D and Feng, T and Schlesinger, S and Janszky, I and Norat, T and Riboli, E},
doi = {10.1016/j.jdiacomp.2018.02.004},
journal = {Journal of Diabetes and its Complications},
pages = {501--511},
title = {Diabetes mellitus, blood glucose and the risk of atrial fibrillation: A systematic review and meta-analysis of cohort studies},
url = {http://dx.doi.org/10.1016/j.jdiacomp.2018.02.004},
volume = {32},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Diabetes and elevated blood glucose have been associated with increased risk of atrial fibrillation in a number of epidemiological studies, however, the findings have not been entirely consistent. We conducted a systematic review and meta-analysis to clarify the association. MATERIAL AND METHODS: We searched the PubMed and Embase databases for studies of diabetes and blood glucose and atrial fibrillation up to July 18th 2017. Cohort studies were included if they reported relative risk (RR) estimates and 95% confidence intervals (CIs) of atrial fibrillation associated with a diabetes diagnosis, prediabetes or blood glucose. Summary RRs were estimated using a random effects model. RESULTS: Thirty four studies were included in the meta-analysis of diabetes, pre-diabetes or blood glucose and atrial fibrillation. Thirty two cohort studies (464,229 cases, >10,244,043 participants) were included in the analysis of diabetes mellitus and atrial fibrillation. The summary RR for patients with diabetes mellitus versus patients without diabetes was 1.30 (95% CIs: 1.03-1.66), however, there was extreme heterogeneity, I2= 99.9%) and evidence of publication bias with Begg's test, p<0.0001. After excluding a very large and outlying study the summary RR was 1.28 (95% CI: 1.22-1.35, I2=90%, n=31, 249,772 cases, 10,244,043 participants). The heterogeneity was mainly due to differences in the size of the association between studies and the results persisted in a number of subgroup and sensitivity analyses. The summary RR was 1.20 (95% CI: 1.03-1.39, I2=30%, n=4, 2392 cases, 58,547 participants) for the association between prediabetes and atrial fibrillation. The summary RR was 1.11 (95% CI: 1.04-1.18, I2=61%, n=4) per 20mg/dl increase of blood glucose in relation to atrial fibrillation (3385 cases, 247,447 participants) and there was no evidence of nonlinearity, pnonlinearity= 0.34. CONCLUSIONS: This meta-analysis suggest that prediabetes and diabetes
AU  - Aune,D
AU  - Feng,T
AU  - Schlesinger,S
AU  - Janszky,I
AU  - Norat,T
AU  - Riboli,E
DO  - 10.1016/j.jdiacomp.2018.02.004
EP  - 511
PY  - 2018///
SN  - 1056-8727
SP  - 501
TI  - Diabetes mellitus, blood glucose and the risk of atrial fibrillation: A systematic review and meta-analysis of cohort studies
T2  - Journal of Diabetes and its Complications
UR  - http://dx.doi.org/10.1016/j.jdiacomp.2018.02.004
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29653902
UR  - http://hdl.handle.net/10044/1/58569
VL  - 32
ER  -
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