Publications
144 results found
Treibel TA, Mawdsley J, Negus R, et al., 2008, Endoscopy for dysphagia in young patients, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A102-A102, ISSN: 0017-5749
Walker D, Orchard T, 2008, Do Extraintestinal Manifestations Predict Disease Course, Severity, and/or Activity in IBD?, INFLAMMATORY BOWEL DISEASES, Vol: 14, Pages: S200-S201, ISSN: 1078-0998
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- Citations: 3
Purkayastha S, Tekkis PP, Lanitis S, et al., 2006, A comparison of segmental vs subtotal/total colectomy for colonic Crohn's disease: a meta-analysis., Colorectal Dis, Vol: 8, Pages: 723-724, ISSN: 1462-8910
Purpose: To evaluate differences in short- and long-term outcomes of patients with colonic Crohn's disease (CD) undergoing either subtotal/total colectomy with ileorectal anastomosis (IRA) or segmental colectomy(SC). Method: Comparative studies from 1988 to 2002, of subtotal/total colectomy and IRA vs SC, were used. The study end points included surgical and overall recurrence, time to recurrence, postoperative morbidity and incidence of permanent stoma. Meta-analytical tools were used to evaluate the study outcomes. Results: Six studies, consisting of a total of 488 patients (223-IRA and 265-SC) were included. Meta-analysis suggested no significant difference between IRA and SC in recurrence of CD. Time to recurrence was longer in the IRA group by 4.4 years (95%CI, 3.1-5.8), P < 0.001. There was no difference in postoperative complications (OR = 1.4, 95%CI, 0.16-12.74) or the need for a permanent stoma between the two groups (OR = 2.75, 95%CI, 0.78-9.71). Patients with two or more colonic segments involved were associated with lower re-operation rate in the IRA group, a difference which did not reach statistical significance (P = 0.177). Conclusions: Both procedures were equally effective as treatment options for colonic CD, however, patients in the SC group exhibited recurrence earlier than those in the IRA group. The choice of operation is dependent on the extent of colonic disease, with a trend towards better outcomes with IRA for two or more colonic segments involved.
Reese GE, Constantinides VA, Simillis C, et al., 2006, Diagnostic precision of anti-<i>Saccharomyces cerevisiae</i> antibodies and perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease, AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol: 101, Pages: 2410-2422, ISSN: 0002-9270
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- Citations: 170
Orchard T, Probert CS, Keshav S, 2006, Review article: maintenance therapy in patients with ulcerative colitis, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 24, Pages: 17-22, ISSN: 0269-2813
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- Citations: 19
Hoare JM, MacDonald D, Siddiqui A, et al., 2006, Peptic ulcers are being undertreated due to the lack of availability of specialist nursing and equipment out of hours: An audit of 116 consecutive referrals for GI bleeding, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A90-A91, ISSN: 0017-5749
Purkayastha S, Tekkis PP, Lanitis S, et al., 2006, A comparison of segmental versus subtotal/total colectomy for colonic Crohn’s disease: a meta-analysis., Royal Society of Medicine, Section of Coloproctology, Publisher: Wiley, Pages: 82-90, ISSN: 1463-1318
Objective Using meta-analytical techniques the presentstudy evaluated differences in short-term and long-termoutcomes of adult patients with colonic Crohn’s diseasewho underwent either colectomy with ileorectal anastomosis(IRA) or segmental colectomy (SC).Methods Comparative studies published between 1988and 2002, of subtotal ⁄ total colectomy and ileorectalanastomosis vs segmental colectomy, were used. Thestudy end points included were surgical and overallrecurrence, time to recurrence, postoperative morbidityand incidence of permanent stoma. Random and fixedeffectmeta-analytical models were used to evaluate thestudy outcomes. Sensitivity analysis, funnel plot andmeta-regressive techniques were carried out to explainthe heterogeneity and selection bias between the studies.Results Six studies, consisting of a total of 488 patients(223 IRA and 265 SC) were included. Analysis of thedata suggested that there was no significant differencebetween IRA and SC in recurrence of Crohn’s disease.Time to recurrence was longer in the IRA group by4.4 years (95% CI: 3.1–5.8), P < 0.001. There was nodifference between the incidence of postoperative complications(OR ¼ 1.4., 95% CI 0.16–12.74) or the needfor a permanent stoma between the two groups (OR ¼2.75, 95% CI 0.78–9.71). Patients with two or morecolonic segments involved were associated with lower reoperationrate in the IRA group, a difference which didnot reach statistical significance (P ¼ 0.177).Conclusions Both procedures were equally effective astreatment options for colonic Crohn’s disease however,patients in the SC group exhibited recurrence earlier thanthose in the IRA group. The choice of operation isdependent on the extent of colonic disease, with a trendtowards better outcomes with IRA for two or morecolonic segments involved. Since no prospective randomisedstudy has been undertaken, a clear view aboutwhich approach is more suitable for localised colo
Rashid ST, Thursz MR, Razvi NA, et al., 2005, Venous thromboprophylaxis in UK medical inpatients, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 98, Pages: 507-512, ISSN: 0141-0768
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- Citations: 66
Moorthy K, Munz Y, Orchard TR, et al., 2004, An innovative method for the assessment of skills in lower gastrointestinal endoscopy, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 18, Pages: 1613-1619, ISSN: 0930-2794
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- Citations: 26
Orchard T, 2003, Extraintestinal complications of inflammatory bowel disease., Curr Gastroenterol Rep, Vol: 5, Pages: 512-517, ISSN: 1522-8037
Recent studies of extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) have demonstrated the importance of genetic predisposition in the etiology of musculoskeletal and cutaneous manifestations. In addition, small studies have shown infliximab to be effective in treating troublesome EIMs, particularly in pyoderma gangrenosum. Other trials have examined the safety of cyclooxygenase-2-specific nonsteroidal inflammatory drugs in IBD. Further work has been done on osteoporosis in IBD, and the American Gastroenterological Association has published a technical review and management guidelines for osteoporosis in a range of gastrointestinal disorders. However, despite further publications, debate remains concerning whether IBD patients with osteoporosis have a significant increase in fracture risk, and whether the bone loss is related to the disease or to its treatment.
Holden W, Orchard T, Wordsworth P, 2003, Enteropathic arthritis, RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, Vol: 29, Pages: 513-+, ISSN: 0889-857X
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- Citations: 56
Armuzzi A, Ahmad T, Ling KL, et al., 2003, Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31, GUT, Vol: 52, Pages: 1133-1139, ISSN: 0017-5749
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- Citations: 125
Orchard TR, Ahmad T, Jewell DP, 2003, NOD2/CARD15 mutations in the extraintestinal manifestations (EIMS) of inflammatory bowel disease, Annual meeting of the British-Society-of-Gastroenterology, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A59-A60, ISSN: 0017-5749
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- Citations: 1
Ahmad T, Orchard T, Armuzzi A, et al., 2003, NOD2 insertion mutation in a Cretan Crohn's disease population - Reply, GASTROENTEROLOGY, Vol: 124, Pages: 273-274, ISSN: 0016-5085
Mitchell SA, Thyssen M, Orchard TR, et al., 2002, Cigarette smoking, appendectomy, and tonsillectomy as risk factors for the development of primary sclerosing cholangitis: a case control study, GUT, Vol: 51, Pages: 567-573, ISSN: 0017-5749
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- Citations: 70
Orchard TR, Chua CN, Ahmad T, et al., 2002, Uveitis and erythema nodosum in inflammatory bowel disease: Clinical features and the role of HLA genes, GASTROENTEROLOGY, Vol: 123, Pages: 714-718, ISSN: 0016-5085
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- Citations: 166
Ahmad T, Marshall SE, Mulcahy-Hawes K, et al., 2002, High resolution MIC genotyping: Design and application to the investigation of inflammatory bowel disease susceptibility, TISSUE ANTIGENS, Vol: 60, Pages: 164-179, ISSN: 0001-2815
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- Citations: 41
Fraser AG, Orchard TR, Robinson EM, et al., 2002, Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 16, Pages: 1225-1232, ISSN: 0269-2813
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- Citations: 152
Fraser AG, Orchard TR, Jewell DP, 2002, The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review, GUT, Vol: 50, Pages: 485-489, ISSN: 0017-5749
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- Citations: 506
Ahmad T, Armuzzi A, Bunce M, et al., 2002, The molecular classification of the clinical manifestations of Crohn's disease, GUT, Vol: 50, Pages: A15-A15, ISSN: 0017-5749
Ahmad T, Armuzzi A, Bunce M, et al., 2002, The molecular classification of the clinical manifestations of Crohn's disease, GASTROENTEROLOGY, Vol: 122, Pages: 854-866, ISSN: 0016-5085
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- Citations: 508
Orchard TR, Dhar A, Simmons JD, et al., 2001, MHC class I chain-like gene A (MICA) and its associations with inflammatory bowel disease and peripheral arthropathy, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 126, Pages: 437-440, ISSN: 0009-9104
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- Citations: 60
Smale S, Natt RS, Orchard TR, et al., 2001, Inflammatory bowel disease and spondylarthropathy., Arthritis Rheum, Vol: 44, Pages: 2728-2736, ISSN: 0004-3591
Orchard TR, Ahmad T, Welsh KI, et al., 2001, Extraintestinal manifestations of inflammatory bowel disease (IBD) and polymorphisms in the TNFα gene:: Further evidence for phenotype determining genes in the MHC region on chromosome 6, GASTROENTEROLOGY, Vol: 120, Pages: A456-A456, ISSN: 0016-5085
Ahmad T, Bunce M, Crawshaw J, et al., 2001, Is there a role for MICA and MICB in determining susceptibility and phenotype in inflammatory bowel disease?, GASTROENTEROLOGY, Vol: 120, Pages: A458-A459, ISSN: 0016-5085
Orchard TR, Ahmad T, Welsh KI, et al., 2001, TNFα gene polymorphisms and extraintestinal manifestations of IBD:: Further evidence for phenotype determining genes in the MHC region, GUT, Vol: 48, Pages: A83-A83, ISSN: 0017-5749
Ahmad T, Bunce M, Crawshaw J, et al., 2001, Is there a role for MICA and MICB in determining susceptibility and phenotype in ulcerative colitis?, GUT, Vol: 48, Pages: A84-A84, ISSN: 0017-5749
Watanabe K, Simmons JD, Orchard TR, et al., 2000, Allelic variants, of thiopurine methyl transferase are associated with Azathioprine, induced leukopaenia., GASTROENTEROLOGY, Vol: 118, Pages: A338-A338, ISSN: 0016-5085
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- Citations: 1
Orchard TR, Chua C, Cheng H, et al., 2000, Clinical features of erythema nodosum (EN) and uveitis associated with inflammatory bowel disease (IBD)., GASTROENTEROLOGY, Vol: 118, Pages: A120-A120, ISSN: 0016-5085
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- Citations: 3
Fraser AG, Orchard TR, Jewell DP, 2000, Relapse rates on and after stopping azathioprine treatment for IBD, GUT, Vol: 46, Pages: A12-A12, ISSN: 0017-5749
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- Citations: 1
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