Imperial College London
Professor Timothy Orchard

ProfessorTimothyOrchard

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Gastroenterology
 
 
 
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Contact

 

t.orchard

 
 
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Location

 

GI UnitNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Russo:2016:10.1097/MIB.0000000000000924,
author = {Russo, E and Khan, S and Janisch, R and Gunn, R and Rabiner, E and Taylor, SA and Matthews, P and Orchard, T},
doi = {10.1097/MIB.0000000000000924},
journal = {Inflammatory Bowel Diseases},
title = {Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohn's Disease.},
url = {http://dx.doi.org/10.1097/MIB.0000000000000924},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: 18Fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG PET) has recently attracted interest for the measurement ofdisease activity in Crohn’s disease (CD). The aim of this study was to assess the utility of FDG-PET as a marker of progression of inflammatory activityand its response to treatment in patients with CD.Methods: Twenty-two patients with active CD were recruited prospectively to undergo FDG-PET scanning at 2 time points. All 22 index scans were used toassess sensitivity and specificity against a reference standard magnetic resonance imaging measure. Correlations with clinicopathological markers of severity(Harvey-Bradshaw Index, C-reactive protein, and calprotectin) were also performed. Of note, 17/22 patients participated in the longitudinal component andunderwent scanning before and 12 weeks after the initiation of anti–tumor necrosis factor alpha therapy. Patients were subcategorized on the basis ofa clinically significant response, and responsiveness of the PET measures was assessed using previously described indices. Of note, 5/22 patients took partin the test–retest component of the study and underwent scanning twice within a target interval of 1 week, to assess the reproducibility of the PET measures.Results: The sensitivity and specificity of 18F-FDG PET were 88% and 70%, respectively. Standardized uptake value (SUV)-related PET measurescorrelated significantly both with C-reactive protein and Harvey-Bradshaw Index in cross-sectional and longitudinal analyses. (G)SUVMAX and (G)SUVMEANdemonstrated favorable responsiveness and reliability characteristics (responsiveness ratio of Guyatt .0.80 and % variability ,20%) compared with volumedependentFDG-PET measures. A proportion of the FDG signal (10%–30%) was found to originate from the lumen of diseased segments.Conclusions: 18F-FDG PET may be useful for longitudinal monitoring of inflammatory activity in CD.
AU  - Russo,E
AU  - Khan,S
AU  - Janisch,R
AU  - Gunn,R
AU  - Rabiner,E
AU  - Taylor,SA
AU  - Matthews,P
AU  - Orchard,T
DO  - 10.1097/MIB.0000000000000924
PY  - 2016///
SN  - 1536-4844
TI  - Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohn's Disease.
T2  - Inflammatory Bowel Diseases
UR  - http://dx.doi.org/10.1097/MIB.0000000000000924
ER  -
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