Imperial College London


Faculty of EngineeringDepartment of Bioengineering

Reader in Biomolecular Systems



t.ouldridge Website CV




4.04Royal School of MinesSouth Kensington Campus





I am a Royal Society University Research Fellow in the Bioengineering Department, where I lead the "Principles of Biomolecular Systems" group

My group probes the fundamental principles underlying complex biochemical systems through theoretical modelling, simulation and experiment. In particular, We focus on the interplay between the detailed biochemistry and the overall output of a process such as sensing, replication or self-assembly. We're inspired by natural systems, and aim to explore the possibilities of engineering artificial analogs. For more details, including open positions and recent work, please refer to our group page.

Our take on the most recent developments in the field can be found in the blog that we run.





Ouldridge T, Hertel S, Spinney R, et al., 2022, The stability and number of nucleating interactions determine DNA hybridisation rates in the absence of secondary structure, Nucleic Acids Research, Vol:50, ISSN:0305-1048, Pages:7829-7841

Ledesma Amaro R, Ouldridge T, O'Hare D, et al., 2022, Synthetic biology and bioelectrochemical tools for electrogenetic system engineering, Science Advances, Vol:8, ISSN:2375-2548

Climent-Catala A, Ouldridge TE, Stan G-BV, et al., 2022, Building an RNA-based toggle switch using inhibitory RNA aptamers, Acs Synthetic Biology, Vol:11, ISSN:2161-5063, Pages:562-569

Juritz J, Poulton JM, Ouldridge TE, 2022, Minimal mechanism for cyclic templating of length-controlled copolymers under isothermal conditions, Journal of Chemical Physics, Vol:156, ISSN:0021-9606

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