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@article{Deshpande:2017:10.1049/enb.2017.0017,
author = {Deshpande, A and Ouldridge, TE},
doi = {10.1049/enb.2017.0017},
journal = {Engineering Biology},
pages = {86--99},
title = {High rates of fuel consumption are not required by insulating motifs to  suppress retroactivity in biochemical circuits},
url = {http://dx.doi.org/10.1049/enb.2017.0017},
volume = {1},
year = {2017}
}

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TY  - JOUR
AB  - Retroactivity arises when the coupling of a molecular network $\mathcal{U}$to a downstream network $\mathcal{D}$ results in signal propagation back from$\mathcal{D}$ to $\mathcal{U}$. The phenomenon represents a breakdown inmodularity of biochemical circuits and hampers the rational design of complexfunctional networks. Considering simple models of signal-transductionarchitectures, we demonstrate the strong dependence of retroactivity on theproperties of the upstream system, and explore the cost and efficacy offuel-consuming insulating motifs that can mitigate retroactive effects. We findthat simple insulating motifs can suppress retroactivity at a low fuel cost bycoupling only weakly to the upstream system $\mathcal{U}$. However, this designapproach reduces the signalling network's robustness to perturbations from leakreactions, and potentially compromises its ability to respond torapidly-varying signals.
AU  - Deshpande,A
AU  - Ouldridge,TE
DO  - 10.1049/enb.2017.0017
EP  - 99
PY  - 2017///
SN  - 2398-6182
SP  - 86
TI  - High rates of fuel consumption are not required by insulating motifs to  suppress retroactivity in biochemical circuits
T2  - Engineering Biology
UR  - http://dx.doi.org/10.1049/enb.2017.0017
UR  - http://hdl.handle.net/10044/1/54446
VL  - 1
ER  -

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