Publications
264 results found
Serb A, Berdan R, Khiat A, et al., 2014, Memristors as synapse emulators in the context of event-based computation, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2085-2088, ISSN: 0271-4302
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- Citations: 1
Trantidou T, Tariq M, Pinto K, et al., 2014, A lab-on-chip approach for monitoring the electrochemical activity of biorealistic cell cultures, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 642-645, ISSN: 0271-4302
Wizenberg R, Khiat A, Berdan R, et al., 2014, Applications of Solid-State Memristors in Tunable Filters, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2269-2272, ISSN: 0271-4302
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- Citations: 4
Berdan R, Khiat A, Papavassiliou C, et al., 2014, Qualitative SPICE modeling accounting for volatile dynamics of TiO<sub>2</sub> memristors, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2033-2036, ISSN: 0271-4302
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- Citations: 1
Reverter F, Prodromakis T, Liu Y, et al., 2014, Design Considerations for a CMOS Lab-on-Chip Microheater Array to Facilitate the in vitro Thermal Stimulation of Neurons, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 630-633
Serb A, Berdan R, Khiat A, et al., 2014, Live demonstration: A versatile, low-cost platform for testing large ReRAM cross-bar arrays., IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 441-441, ISSN: 0271-4302
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- Citations: 10
Salaoru I, Khiat A, Li Q, et al., 2013, Pulse-induced resistive and capacitive switching in TiO<sub>2</sub> thin film devices, APPLIED PHYSICS LETTERS, Vol: 103, ISSN: 0003-6951
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- Citations: 31
Trantidou T, Payne DJ, Tsiligkiridis V, et al., 2013, The dual role of Parylene C in chemical sensing: Acting as an encapsulant and as a sensing membrane for pH monitoring applications, Sensors and Actuators B - Chemical, Vol: 186, Pages: 1-8, ISSN: 0925-4005
In this work, we demonstrate a new property of Parylene C emphasizing on its application in pH sensing technologies. For many decades the material has been extensively used as a biocompatible inert encapsulant of implantable micro-devices. Toward a new understanding of the material's potential, we explore the transformation of Parylene C from a passive encapsulation membrane into an active H+ sensing membrane using discrete MOSFETs to evaluate its chemical sensing performance. We employ oxygen plasma treatment to functionalize Parylene's H+ sensing capacity and enhance the chemical sensitivity, drift rates, and reliability of the sensing devices. Moreover, we demonstrate a versatile technique that enables the deployment of the material both as an encapsulant and as a sensing membrane in a single platform, in order to benefit from distinguishable and consistent sensitivities, and low leakage currents during pH measurements. Our investigation reveals that the selective modification of Parylene's surface chemistry yields reliable pH sensing devices, ensuring the best combination of sensitivity (16.3 mV/pH) and leakage currents (6–10 nA) over a reasonably wide pH range (4–10), while drift rates remain in low levels (2.5–20 mV/h). We believe that this study opens up new application horizons for Parylene, which is a new promising material in the emerging field of flexible electronics able to deliver low film thicknesses and high biocompatibility, while facilitating the application of mechanical stimulus.
Trantidou T, Payne DJ, Tsiligkiridis V, et al., 2013, Sensors and Actuators B: Chemical, Sensors and Actuators B: Chemical, Vol: 186, Pages: 1-8
Reverter F, Liu Y, Georgiou P, et al., 2013, Design Considerations for a CMOS Lab-on-Chip Microheater Array to Facilitate the in vitro Thermal Stimulation of Neurons, Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Publisher: IEEE
This paper identifies and addresses key designconsiderations and trade-offs in the implementation of a high resolution microheater array for CMOS Lab-on-Chip (LOC) applications. Specifically, this is investigated in the context of facilitating the in vitro thermal stimulation of single neurons. The paper analyses the electro-thermal response (by means of COMSOL simulations) and reliability issues (such as melting and electromigration) of different microheater designs. The analysis shows that a small-area heater is more efficient in terms of power, but it has more reliability problems essentially due to electromigration effects. For the proposed heater designs, the expected lifetime is a few days (in continuous operation) in the worst scenario, which is still generally acceptable for LOC applications.
Rao C, Prodromakis T, Kolker L, et al., 2013, The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells, Biomaterials, Vol: 34, Pages: 2399-2411, ISSN: 0142-9612
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) have been widely proposed as in vitro models of myocardial physiology and disease. A significant obstacle, however, is their immature phenotype. We hypothesised that Ca2+ cycling of iPSC-CM is influenced by culture conditions and can be manipulated to obtain a more mature cellular behaviour. To test this hypothesis we seeded iPSC-CM onto fibronectin coated microgrooved polydimethylsiloxane (PDMS) scaffolds fabricated using photolithography, or onto unstructured PDMS membrane. After two weeks in culture, the structure and function of iPSC-CM were studied. PDMS microgrooved culture substrates brought about cellular alignment (p < 0.0001) and more organised sarcomere. The Ca2+ cycling properties of iPSC-CM cultured on these substrates were significantly altered with a shorter time to peak amplitude (p = 0.0002 at 1 Hz), and more organised sarcoplasmic reticulum (SR) Ca2+ release in response to caffeine (p < 0.0001), suggesting improved SR Ca2+ cycling. These changes were not associated with modifications in gene expression. Whilst structured tissue culture may make iPSC-CM more representative of adult myocardium, further construct development and characterisation is required to optimise iPSC-CM as a model of adult myocardium.
Lim CKK, Prodromakis T, 2013, Computing Motion with 3D Memristive Grid, arXiv.org
Ye Z, Wu SHM, Prodromakis T, 2013, Computing shortest paths in 2D and 3D memristive networks, arXiv.org
Indiveri G, Linares-Barranco B, Legenstein R, et al., 2013, Integration of nanoscale memristor synapses in neuromorphic computing architectures, arXiv.org
Serrano-Gotarredona T, Masquelier T, Prodromakis T, et al., 2013, STDP and STDP Variations with Memristors for Spiking Neuromorphic Learning Systems, Frontiers in …, Vol: 7, Pages: 1-15
Salaoru I, Prodromakis T, Khiat A, et al., 2013, Resistive switching of oxygen enhanced TiO<sub>2</sub> thin-film devices, APPLIED PHYSICS LETTERS, Vol: 102, ISSN: 0003-6951
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- Citations: 50
Trantidou T, Tariq M, Chang Y-C, et al., 2013, Free-standing Parylene C Thin Films As Flexible pH Sensing Membranes, 12th IEEE Sensors Conference, Publisher: IEEE, Pages: 1827-1830, ISSN: 1930-0395
Berdan R, Prodromakis T, Khiat A, et al., 2013, Temporal Processing with Volatile Memristors, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 425-428, ISSN: 0271-4302
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- Citations: 4
Serrano-Gotarredona T, Prodromakis T, Linares-Barranco B, 2013, A Proposal for Hybrid Memristor-CMOS Spiking Neuromorphic Learning Systems, Circuits and Systems Magazine, IEEE, Vol: 13, Pages: 74-88
Trantidou T, Prodromakis T, Tsiligkiridis V, et al., 2013, Sensing H+ with conventional neural probes, Applied Physics Letters, Vol: 102, ISSN: 1077-3118
In this paper, we demonstrate a technique for transforming commercially available neural probes used for electrical recordings, into chemical sensing devices for detection of ionic concentrations in electrolytes, with particular emphasis to pH. This transformation requires a single post-processing step to incorporate a thin indium tin oxide membrane for sensing H+. Measured results indicate a chemical sensitivity of 28 mV/pH, and relatively low leakage currents (2–10 nA) and drifts (1–10 mV/h). The proposed sensing device demonstrates the possibility of a low-cost implementation that can be reusable and thus versatile, with potential applications in real-time extracellular but mainly intracellular chemical monitoring.
Berdan R, Prodromakis T, Salaoru I, et al., 2012, Memristive devices as parameter setting elements in programmable gain amplifiers, APPLIED PHYSICS LETTERS, Vol: 101, ISSN: 0003-6951
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- Citations: 24
Berdan R, Prodromakis T, Toumazou C, 2012, High precision analogue memristor state tuning, ELECTRONICS LETTERS, Vol: 48, Pages: 1105-1106, ISSN: 0013-5194
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- Citations: 36
Trantidou T, Prodromakis T, Toumazou C, 2012, Oxygen plasma induced hydrophilicity of Parylene-C thin films, Applied Surface Science, Vol: 261, Pages: 43-51, ISSN: 1873-5584
This paper investigates the surface modification of Parylene-C thin films under various oxygen plasma treatment conditions, such as power intensity (50:400 W) and exposure time (1:20 min). The extent of hydrophilicity was investigated through contact angle measurements, and correlations between treatment parameters, film thickness, restoration of hydrophobicity and etching rates were experimentally established. We also demonstrate the selective modification of Parylene-C films, facilitating distinct hydrophilic and hydrophobic areas with μm-resolution that can be exploited in self-alignment applications.
Prodromakis T, Toumazou C, Chua LO, 2012, Two centuries of memristors, Nature Materials, Vol: 11, Pages: 478-481
Prodromakis T, Salaoru I, Khiat A, et al., 2012, Concurrent Resistive and Capacitive Switching of Nanoscale TiO2 Memristors, Nature Conference on Frontiers in Electronic Materials: Correlation Effects and Memristive Phenomena
Prodromakis T, Toumazou C, Chua LO, 2012, Memristors: Two Centuries On, Nature Conference on Frontiers in Electronic Materials: Correlation Effects and Memristive Phenomena
Gelencser A, Prodromakis T, Toumazou C, et al., 2012, Biomimetic model of the outer plexiform layer by incorporating memristive devices, Phys. Rev. E, Vol: 85
In this paper we present a biorealistic model for the first part of the early vision of processing by incorporating memristive nanodevices. The architecture of the proposed network is based on the organization and functioning of the outer plexiform layer (OPL) in the vertebrate retina. We demonstrate that memristive devices are indeed a valuable building block for neuromorphic architectures, as their highly nonlinear and adaptive response could be exploited for establishing ultradense networks with dynamics similar to that of their biological counterparts. We particularly show that hexagonal memristive grids can be employed for faithfully emulating the smoothing effect occurring in the OPL to enhance the dynamic range of the system. In addition, we employ a memristor-based thresholding scheme for detecting the edges of grayscale images, while the proposed system is also evaluated for its adaptation and fault tolerance capacity against different light or noise conditions as well as its distinct device yields.
Gelencsér A, Prodromakis T, Toumazou C, et al., 2012, Biomimetic model of the outer plexiform layer by incorporating memristive devices., Phys Rev E Stat Nonlin Soft Matter Phys, Vol: 85
In this paper we present a biorealistic model for the first part of the early vision of processing by incorporating memristive nanodevices. The architecture of the proposed network is based on the organization and functioning of the outer plexiform layer (OPL) in the vertebrate retina. We demonstrate that memristive devices are indeed a valuable building block for neuromorphic architectures, as their highly nonlinear and adaptive response could be exploited for establishing ultradense networks with dynamics similar to that of their biological counterparts. We particularly show that hexagonal memristive grids can be employed for faithfully emulating the smoothing effect occurring in the OPL to enhance the dynamic range of the system. In addition, we employ a memristor-based thresholding scheme for detecting the edges of grayscale images, while the proposed system is also evaluated for its adaptation and fault tolerance capacity against different light or noise conditions as well as its distinct device yields.
Rao C, Prodromakis T, Chaudhry U, et al., 2012, Sarcoplasmic reticulum calcium release in response to caffeine is more organised in cardiomyocytes differentiated from iPSC cultured on structured substrates suggesting a matured phenotype, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S68-S68, ISSN: 0008-6363
Rao C, Prodromakis T, Chaudhry U, et al., 2012, Structured Culture Scaffolds Improve the Calcium Handling Properties of Cardiomyocytes Differentiated from Induced Pluripotent Stem Cells, BIOPHYSICAL JOURNAL, Vol: 102, Pages: 103A-103A, ISSN: 0006-3495
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- Citations: 1
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