Summary
I am interested in the patterns of gene expression underpinning healthy pancreatic beta cell function. As the body’s sole source of circulating insulin, beta cells are essential for normal regulation of blood glucose, and their failure is the main cause of Type 2 Diabetes.
In recent years it has become apparent that the genome encodes thousands of long non-coding RNAs (lncRNA). lncRNAs are expressed in a highly cell-type specific manner and are capable of regulating gene expression through multiple mechanisms. I am currently investigating how lncRNAs contribute to the healthy beta cell phenotype, and the mechanisms through which they function. I am also interested in whether lncRNAs can be manipulated to reinforce beta cell identity which is challenged during diabetes progression.
My research is funded by a Non-clinical Fellowship from the Diabetes Research and Wellness Foundation.
Publications
Journals
Slieker R, Donnellly L, Akalestou E, et al.Slieker R, Donnellly L, Akalestou E, Lopez-Noriega L, Melhem R, Gunes A, Abou Azar F, Efanov A, Georgiadou E, Muniangi-Muhitu H, Shiekh M, Giordano G, Åkerlund, M, Ahlqvist E, Ashfaq A, Banasik K, Brunak S, Barovic M, Bouland G, Burdet F, Canouil M, Dragan I, Elders P, Fernandez C, Festa A, Fitipaldi H, Froguel P, Gudmundsdottir V, Gudnason V, Gerl M, van der Heijden A, Jennings L, Hansen M, Kim M, Leclerc I, Klose C, Kuznetsov D, Mansour Aly D, Mehl F, Marek D, Melander O, Niknejad A, Ottosson F, Pavo I, Duffin K, Syed S, Shaw J, Cabrera O, Pullen T, Simons K, Solimena M, Suvitaival T, Wretlind A, Rossing P, Lyssenko V, Legido Quigley C, Groop L, Thorens B, Franks P, Lim G, Estall J, Ibberson M, Beulens J, ’t Hart L, Pearson E, Rutter G close, 2023, Identification of biomarkers for glycaemic deterioration in type 2 diabetes, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-18
Wilson ME, Pullen TJ, 2021, The role of long non-coding RNAs in the regulation of pancreatic beta cell identity, Biochemical Society Transactions, Vol:49, ISSN:0300-5127, Pages:2153-2161
Slieker RC, Donnelly LA, Fitipaldi H, et al.Slieker RC, Donnelly LA, Fitipaldi H, Bouland GA, Giordano GN, Åkerlund M, Gerl MJ, Ahlqvist E, Ali A, Dragan I, Elders P, Festa A, Hansen MK, van der Heijden AA, Aly DM, Kim M, Kuznetsov D, Mehl F, Klose C, Simons K, Pavo I, Pullen TJ, Suvitaival T, Wretlind A, Rossing P, Lyssenko V, Quigley CL, Groop L, Thorens B, Franks PW, Ibberson M, Rutter GA, Beulens JW, 't Hart LM, Pearson ER close, 2021, Distinct molecular signatures of clinical clusters in people with Type 2 diabetes: an IMIRHAPSODY study., Diabetes, Vol:70, ISSN:0012-1797, Pages:2683-2693
Slieker RC, Donnelly LA, Fitipaldi H, et al.Slieker RC, Donnelly LA, Fitipaldi H, Bouland GA, Giordano GN, Akerlund M, Gerl MJ, Ahlqvist E, Ali A, Dragan I, Festa A, Hansen MK, Mansour Aly D, Kim M, Kuznetsov D, Mehl F, Klose C, Simons K, Pavo I, Pullen TJ, Suvitaival T, Wretlind A, Rossing P, Lyssenko V, Legido-Quigley C, Groop L, Thorens B, Franks PW, Ibberson M, Rutter GA, Beulens JWJ, 't Hart LM, Pearson ER close, 2021, Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study, Diabetologia, Vol:64, ISSN:0012-186X, Pages:1982-1989
Bornstein SR, Guan K, Brunssen C, et al.Bornstein SR, Guan K, Brunssen C, Mueller G, Kamvissi-Lorenz V, Lechler R, Trembath R, Mayr M, Poston L, Sancho R, Ahmed S, Alfar E, Aljani B, Alves TC, Amiel S, Andoniadou CL, Bandral M, Belavgeni A, Berger I, Birkenfeld A, Bonifacio E, Chavakis T, Chawla P, Choudhary P, Cujba AM, Delgadillo Silva LF, Demcollari T, Drotar DM, Duin S, El-Agroudy NN, El-Armouche A, Eugster A, Gado M, Gavalas A, Gelinsky M, Guirgus M, Hansen S, Hanton E, Hasse M, Henneicke H, Heller C, Hempel H, Hogstrand C, Hopkins D, Jarc L, Jones PM, Kamel M, Kaemmerer S, King AJF, Kurzbach A, Lambert C, Latunde-Dada Y, Lieberam I, Liers J, Li JW, Linkermann A, Locke S, Ludwig B, Manea T, Maremonti F, Marinicova Z, McGowan BM, Mickunas M, Mingrone G, Mohanraj K, Morawietz H, Ninov N, Peakman M, Persaud SJ, Pietzsch J, Cachorro E, Pullen TJ, Pyrina I, Rubino F, Santambrogio A, Schepp F, Schlinkert P, Scriba LD, Siow R, Solimena M, Spagnoli FM, Speier S, Stavridou A, Steenblock C, Strano A, Taylor P, Tiepner A, Tonnus W, Tree T, Watt F, Werdermann M, Wilson M, Yusuf N, Ziegler CG close, 2021, The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease, Hormone and Metabolic Research, Vol:53, ISSN:0018-5043, Pages:204-206
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