Imperial College London

DrTimothyPullen

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Lecturer
 
 
 
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Contact

 

t.pullen Website

 
 
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Location

 

329ICTEM buildingHammersmith Campus

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Summary

 

Summary

I am interested in the patterns of gene expression underpinning healthy pancreatic beta cell function. As the body’s sole source of circulating insulin, beta cells are essential for normal regulation of blood glucose, and their failure is the main cause of Type 2 Diabetes.

In recent years it has become apparent that the genome encodes thousands of long non-coding RNAs (lncRNA). lncRNAs are expressed in a highly cell-type specific manner and are capable of regulating gene expression through multiple mechanisms. I am currently investigating how lncRNAs contribute to the healthy beta cell phenotype, and the mechanisms through which they function. I am also interested in whether lncRNAs can be manipulated to reinforce beta cell identity which is challenged during diabetes progression.

My research is funded by a Non-clinical Fellowship from the Diabetes Research and Wellness Foundation.

Publications

Journals

Wilson ME, Pullen TJ, 2021, The role of long non-coding RNAs in the regulation of pancreatic beta cell identity, Biochemical Society Transactions, Vol:49, ISSN:0300-5127, Pages:2153-2161

Slieker RC, Donnelly LA, Fitipaldi H, et al., 2021, Distinct molecular signatures of clinical clusters in people with Type 2 diabetes: an IMIRHAPSODY study., Diabetes, Vol:70, ISSN:0012-1797, Pages:2683-2693

Slieker RC, Donnelly LA, Fitipaldi H, et al., 2021, Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study, Diabetologia, Vol:64, ISSN:0012-186X, Pages:1982-1989

Bornstein SR, Guan K, Brunssen C, et al., 2021, The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease, Hormone and Metabolic Research, Vol:53, ISSN:0018-5043, Pages:204-206

Carrat GR, Haythorne E, Tomas A, et al., 2020, The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis, Molecular Metabolism, Vol:40, ISSN:2212-8778

More Publications