Publications
386 results found
Paton C, Barnes TR, 2014, Undertaking clinical audit, with reference to a Prescribing Observatory for Mental Health audit of lithium monitoring, BJPsych Bulletin, Vol: 38, Pages: 128-131, ISSN: 2056-4708
Audit is an important tool for quality improvement. The collection of data on clinical performance against evidence-based and clinically relevant standards, which are considered by clinicians to be realistic in routine practice, can usefully prompt reflective practice and the implementation of change. Evidence of participation in clinical audit is required to achieve intended learning outcomes for trainees in psychiatry and revalidation for those who are members of the Royal College of Psychiatrists. This article addresses some of the practical steps involved in conducting an audit project, and, to illustrate key points, draws on lessons learnt from a national, audit-based, quality improvement programme of lithium prescribing and monitoring conducted through the Prescribing Observatory for Mental Health.
Hayhurst KP, Drake RJ, Massie JA, et al., 2014, Improved quality of life over one year is associated with improved adherence in patients with schizophrenia, EUROPEAN PSYCHIATRY, Vol: 29, Pages: 191-196, ISSN: 0924-9338
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- Citations: 36
Barnes T, 2014, Towards collaborative intervention that improves the lives of patients with schizophrenia: clinicians as drivers of policy change, EUROPEAN PSYCHIATRY, Vol: 29, ISSN: 0924-9338
Marder SR, Alphs L, Anghelescu I-G, et al., 2013, Issues and perspectives in designing clinical trials for negative symptoms in schizophrenia, SCHIZOPHRENIA RESEARCH, Vol: 150, Pages: 328-333, ISSN: 0920-9964
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- Citations: 39
Fleischhacker W, Arango C, Arteel P, et al., 2013, Schizophrenia: Time to commit to policy change, Schizophrenia: Time to commit to policy change, Publisher: Oxford PharmaGenesis™ Ltd
Huddy VC, Clark L, Harrison I, et al., 2013, Reflection impulsivity and response inhibition in first-episode psychosis: relationship to cannabis use, PSYCHOLOGICAL MEDICINE, Vol: 43, Pages: 2097-2107, ISSN: 0033-2917
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- Citations: 15
Barnes TRE, Drake RJ, Dunn G, et al., 2013, Effect of prior treatment with antipsychotic long-acting injection on randomised clinical trial treatment outcomes, BRITISH JOURNAL OF PSYCHIATRY, Vol: 203, Pages: 215-220, ISSN: 0007-1250
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- Citations: 10
Patel MX, Arista IA, Taylor M, et al., 2013, How to compare doses of different antipsychotics: A systematic review of methods, SCHIZOPHRENIA RESEARCH, Vol: 149, Pages: 141-148, ISSN: 0920-9964
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- Citations: 69
Peluso MJ, Lewis SW, Barnes TRE, et al., 2013, Non-neurological and metabolic side effects in the Cost Utility of the Latest Antipsychotics in Schizophrenia Randomised Controlled Trial (CUtLASS-1), SCHIZOPHRENIA RESEARCH, Vol: 144, Pages: 80-86, ISSN: 0920-9964
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- Citations: 6
Paton C, Adroer R, Barnes TR, 2013, Monitoring lithium therapy: The impact of a quality improvement programme in the UK, Bipolar Disorders, ISSN: 1398-5647
Objectives: The study was designed to test an audit-based quality improvement programme (QIP) addressing lithium prescribing and monitoring in UK mental health services. Methods: A baseline clinical audit was conducted against the following standards: (i) measurement of renal and thyroid function before initiating treatment with lithium and (ii) recommended monitoring of serum lithium and renal and thyroid function during maintenance treatment. A re-audit was conducted at 18 months and a supplementary audit at three years. Results: Data were submitted for patients at baseline (n = 3,373), re-audit (n = 3,647), and supplementary audit (n = 5,683), 57% of whom had bipolar disorder. The baseline findings prompted a patient safety alert issued by the National Patient Safety Agency. By supplementary audit, the proportion of patients having four serum lithium tests over the previous year had increased from 30% at baseline to 48%, and the respective proportions that had two tests of renal function from 55% to 70% and thyroid function from 49% to 66%. Elderly patients and those prescribed a drug known to interact with lithium were not more likely to be monitored in line with the audit standards. Between baseline and supplementary audit, the proportion of patients with a diagnosis of bipolar disorder prescribed an antidepressant increased from 36% to 41%. Conclusions: Improvements in biochemical monitoring of lithium treatment were achieved over time with participation in a QIP that included benchmarking of performance against clinical standards and customized change interventions. Nevertheless, gaps remain between the standard and current practice. Antidepressants are frequently prescribed in patients with bipolar disorder despite a paucity of evidence supporting their efficacy. © 2013 John Wiley & Sons A/S.
Barnes TRE, Paton C, 2012, Role of the Prescribing Observatory for Mental Health, BRITISH JOURNAL OF PSYCHIATRY, Vol: 201, Pages: 428-429, ISSN: 0007-1250
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- Citations: 7
Peluso MJ, Lewis SW, Barnes TRE, et al., 2012, Extrapyramidal side-effects and antipsychotics: are second-generation agents still indicated? reply, BRITISH JOURNAL OF PSYCHIATRY, Vol: 201, Pages: 247-248, ISSN: 0007-1250
Barnes TR, Banerjee S, Collins N, et al., 2012, Antipsychotics in dementia: prevalence and quality of antipsychotic drug prescribing in UK mental health services., Br J Psychiatry, Vol: 201, Pages: 221-226
Up to a quarter of people in the UK with a diagnosis of dementia are prescribed an antipsychotic in any year. The potential risks of such treatment are becoming clearer, but the benefits remain uncertain. Concern about the frequency and quality of such prescribing was expressed in the National Dementia Strategy for England in 2009.
Chu EM-Y, Kolappan M, Barnes TRE, et al., 2012, A window into the brain: An in vivo study of the retina in schizophrenia using optical coherence tomography, PSYCHIATRY RESEARCH-NEUROIMAGING, Vol: 203, Pages: 89-94, ISSN: 0925-4927
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- Citations: 101
Peluso MJ, Lewis SW, Barnes TRE, et al., 2012, Extrapyramidal motor side-effects of first- and second-generation antipsychotic drugs, BRITISH JOURNAL OF PSYCHIATRY, Vol: 200, Pages: 387-392, ISSN: 0007-1250
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- Citations: 121
Galve LBG, Wheeler-Kingshott CAM, Altmann DR, et al., 2012, CORTICAL THINNING OVER TWO YEARS FOLLOWING THE FIRST EPISODE OF PSYCHOSIS: RELATIONSHIP TO TREATMENT DURATION AND COGNITIVE IMPAIRMENT, SCHIZOPHRENIA RESEARCH, Vol: 136, Pages: S205-S205, ISSN: 0920-9964
Barnes TRE, Paton C, 2012, IMPROVING SIDE EFFECT MONITORING IN PEOPLE PRESCRIBED LONG-ACTING ANTIPSYCHOTIC INJECTIONS: A UK QUALITY IMPROVEMENT PROGRAMME, SCHIZOPHRENIA RESEARCH, Vol: 136, Pages: S258-S258, ISSN: 0920-9964
Crawford MJ, Killaspy H, Barnes TRE, et al., 2012, Group art therapy as an adjunctive treatment for people with schizophrenia: multicentre pragmatic randomised trial, BMJ-BRITISH MEDICAL JOURNAL, Vol: 344, ISSN: 1756-1833
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- Citations: 67
Crawford MJ, Killaspy H, Barnes TR, et al., 2012, Group art therapy as an adjunctive treatment for people with schizophrenia: a randomised controlled trial (MATISSE), HEALTH TECHNOLOGY ASSESSMENT, Vol: 16, Pages: 1-+, ISSN: 1366-5278
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- Citations: 37
Price O, Baker J, Paton C, et al., 2012, Patient Group Directions: a safe and effective practice?, Br J Nurs, Vol: 21, Pages: 26-31, ISSN: 0966-0461
Patient Group Directions (PGDs) have been used in clinical practice for a decade. They enable non-medical practitioners to supply medicines to patients, in certain legally defined circumstances, without a doctor's prescription and in accordance with a pre-defined protocol. The authors aimed to review the existing literature in order to identify and evaluate the evidence regarding the quality, safety and acceptability of PGDs within care systems and their impact on health outcomes. Searches of relevant databases were conducted, articles screened against eligibility criteria and relevant data extracted. A number of key issues emerged from the data including quality and safety of practice, acceptability to patients and practitioners, access to treatment and implications for professional roles and responsibilities. There were no data related to health outcomes. The review concludes that while PGDs may be an acceptable way to deliver care, their impact on patient outcomes and health status has been poorly studied.
Barnes TR, Drake M, Paton C, 2012, Nocturnal enuresis with antipsychotic medication, British Journal of Psychiatry, Vol: 200(1), Pages: 7-9, ISSN: 0007-1250
Nocturnal enuresis can be discomfiting and troublesome. There is increasing evidence that as a side-effect of second-generation antipsychotics, particularly clozapine, it may be underrecognised. Direct but sensitive questioning may be required to elicit this side-effect. We briefly review possible mechanisms of this problem, and management and treatment options.
Crawford MJ, Kakad S, Rendel C, et al., 2011, Medication prescribed to people with personality disorder: the influence of patient factors and treatment setting, ACTA PSYCHIATRICA SCANDINAVICA, Vol: 124, Pages: 396-402, ISSN: 0001-690X
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- Citations: 22
Barnes TRE, 2011, Pursuing the rational pharmacological treatment of schizophrenia, NEUROPSYCHIATRY, Vol: 1, Pages: 425-430, ISSN: 1758-2008
Harrison PJ, Baldwin DS, Barnes TRE, et al., 2011, No psychiatry without psychopharmacology, BRITISH JOURNAL OF PSYCHIATRY, Vol: 199, Pages: 263-265, ISSN: 0007-1250
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- Citations: 19
Huddy VC, Hodgson TL, Ron MA, et al., 2011, Abnormal negative feedback processing in first episode schizophrenia: evidence from an oculomotor rule switching task, PSYCHOLOGICAL MEDICINE, Vol: 41, Pages: 1805-1814, ISSN: 0033-2917
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- Citations: 6
Barnes MR, Huxley-Jones J, Maycox PR, et al., 2011, Transcription and Pathway Analysis of the Superior Temporal Cortex and Anterior Prefrontal Cortex in Schizophrenia, JOURNAL OF NEUROSCIENCE RESEARCH, Vol: 89, Pages: 1218-1227, ISSN: 0360-4012
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- Citations: 63
Leeson V, Barnes TRE, Harrison I, et al., 2011, DO PEOPLE DEVELOPING PSYCHOSIS IN THE CONTEXT OF CANNABIS USE HAVE BETTER COGNITIVE FUNCTION BECAUSE THEY HAVE FEWER NEURODEVELOPMENTAL RISK FACTORS?, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A76-A76, ISSN: 0269-8811
Barnes TRE, McIntyre S, Bhatti S, et al., 2011, MEDICINES RECONCILIATION: ADHERENCE TO MEDICATION ON ADMISSION TO A PSYCHIATRIC WARD, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A65-A65, ISSN: 0269-8811
Paton C, McIntyre S, Barnes TRE, 2011, SCREENING FOR THE METABOLIC SIDE EFFECTS OF ANTIPSYCHOTIC MEDICATION IN PATIENTS UNDER THE CARE OF ASSERTIVE OUTREACH TEAMS: RESULTS OF A POMH AUDIT-BASED QUALITY IMPROVEMENT PROGRAMME, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A65-A65, ISSN: 0269-8811
Leeson VC, Sharma P, Harrison M, et al., 2011, IQ Trajectory, Cognitive Reserve, and Clinical Outcome Following a First Episode of Psychosis: A 3-Year Longitudinal Study, SCHIZOPHRENIA BULLETIN, Vol: 37, Pages: 768-777, ISSN: 0586-7614
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- Citations: 80
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