Imperial College London
Dr Tushar Salukhe

DrTusharSalukhe

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2154t.salukhe Website

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Drewitz:2010:10.1161/CIRCEP.110.945279,
author = {Drewitz, I and Willems, S and Salukhe, TV and Steven, D and Hoffmann, BA and Servatius, H and Bock, K and Aydin, MA and Wegscheider, K and Meinertz, T and Rostock, T},
doi = {10.1161/CIRCEP.110.945279},
journal = {Circ Arrhythm Electrophysiol},
pages = {351--360},
title = {Atrial fibrillation cycle length is a sole independent predictor of a substrate for consecutive arrhythmias in patients with persistent atrial fibrillation.},
url = {http://dx.doi.org/10.1161/CIRCEP.110.945279},
volume = {3},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Termination of persistent atrial fibrillation (AF) can be achieved through ablation, with the majority of patients terminating to an atrial tachycardia (AT) and fewer directly to sinus rhythm (SR). We aimed to identify potential predictors for the existence of a substrate for AT on termination to SR. METHODS AND RESULTS: We assessed 95 persistent AF patients (age, 60+/-10 years) who underwent catheter ablation to the end point of AF termination. Forty patients terminated directly to SR (SRterm) and 55 to ATs (ATterm). Compared with the ATterm group, the SRterm group were younger (56+/-10 versus 63+/-9 years, P=0.001), had shorter durations of AF before ablation (9+/-26 versus 14+/-20 months, P<0.001), smaller left atrial diameters (41+/-5 versus 45+/-5 mm, P=0.015), and longer baseline AF cycle lengths (178+/-23 versus 159+/-31 ms, P=0.005). However, AF cycle length was the sole independent predictor of direct termination to SR. The most frequent AF termination site in SRterm patients was the pulmonary veins (53%), whereas in ATterm patients this was within the left atrium (58%). After follow-up of 12+/-6 months, there was a trend toward a greater proportion of patients in SR among those who terminated directly to SR after a single procedure. The most frequent type of recurrence was paroxysmal AF in SRterm patients and AT in ATterm patients. CONCLUSIONS: Patients who terminate to SR through ablation without an intermediate AT are characterized by a less altered arrhythmogenic substrate. Baseline AF cycle lengths emerged as a sole independent predictor of a substrate for consecutive arrhythmias.
AU  - Drewitz,I
AU  - Willems,S
AU  - Salukhe,TV
AU  - Steven,D
AU  - Hoffmann,BA
AU  - Servatius,H
AU  - Bock,K
AU  - Aydin,MA
AU  - Wegscheider,K
AU  - Meinertz,T
AU  - Rostock,T
DO  - 10.1161/CIRCEP.110.945279
EP  - 360
PY  - 2010///
SP  - 351
TI  - Atrial fibrillation cycle length is a sole independent predictor of a substrate for consecutive arrhythmias in patients with persistent atrial fibrillation.
T2  - Circ Arrhythm Electrophysiol
UR  - http://dx.doi.org/10.1161/CIRCEP.110.945279
UR  - https://www.ncbi.nlm.nih.gov/pubmed/20511536
VL  - 3
ER  -
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