Imperial College London


Faculty of MedicineSchool of Public Health

Deputy Operations Manager







Stadium House, 68 Wood LaneStadium HouseWhite City Campus





Dr Thiagarajah Sasikaran (Sasi) works as the Deputy Operations Manager in the division of Surgery within the UKCRC registered Imperial Clinical Trials Unit (ICTU). He joined Imperial College in 2002 and has extensive experience in the delivery of large scale, multi-centre, international clinical trials. His main interest remains focused on innovative trial design and delivery, to enable key questions to be answered quickly and robustly. Adaptive trial designs include multi-arm, multi-stage RCTs (MAMS) and Trials WithIn Cohorts (TWICS).

Sasi currently oversees the full trial management process for the Imperial Prostate (IP) portfolio of studies including CHRONOS (Comparative Health Research Outcomes of Novel Surgery in prostate cancer), ATLANTA (Additional Treatments to the Local tumour for metastatic prostate cancer: Assessment of Novel Treatment Algorithms), PROSPECT (PROState Pathway Embedded Comparative Trial) and CHAIROS (Cancer Histology Artificial Intelligence Reliability Study) from applying for funding through to reporting of results.

He has previously managed and delivered numerous multi-centre randomised clinical trials listed below: AVATAR- AF trial (Ablation Versus Anti-arrhythmic Therapy for reducing All hospital episodes from Recurrent Atrial Fibrillation), SERCA-LVAD trial (Investigation of the safety and feasibility of SERCA2a gene transfer in patients with chronic heart failure and a left ventricular assist device), AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of Ace-inhibition on RisK), FOURIER trial (Further Cardiovascular Outcomes Research with PCSK9 inhibition in subjects with Elevated Risks), CVLPRI-t trial (Complete Versus Lesion-only PRimary PCI Pilot) and PILL Pilot (A randomised placebo-controlled trial of fixed-dose combination medication in people at raised risk of cardiovascular disease).



Patel P, Thomas R, Hamady M, et al., 2023, EMBIO trial study protocol: left gastric artery embolisation for weight loss in patients living with obesity with a BMI 35-50 kg/m2., Bmj Open, Vol:13

Kanagaratnam P, McCready J, Tayebjee M, et al., 2023, Ablation versus anti-arrhythmic therapy for reducing all hospital episodes from recurrent atrial fibrillation: a prospective, randomized, multi-centre, open label trial, Ep Europace, Vol:25, ISSN:1099-5129, Pages:863-872

Fiorentino F, Fiorentino F, 2021, Feasibility of Comparative Health Research Outcome of Novel Surgery in prostate cancer (IP4-CHRONOS): statistical analysis plan for the randomised feasibility phase of the CHRONOS study., Trials, Vol:22, ISSN:1745-6215, Pages:1-12

Bass EJ, Klimowska-Nassar N, Sasikaran T, et al., 2021, PROState pathway embedded comparative trial: the IP3-PROSPECT study, Contemporary Clinical Trials, Vol:107, ISSN:1551-7144


Bass EJ, Klimowska-Nassar N, Sasikaran T, et al., 2022, PROState pathway embedded comparative trial: An update to the IP3-PROSPECT study, ELSEVIER, Pages:S506-S506, ISSN:0302-2838

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