Imperial College London
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Tony D. Southall

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Genetics
 
 
 
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Contact

 

+44 (0)20 7594 5338t.southall

 
 
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Location

 

407Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Demarco:2022:10.1016/j.celrep.2022.110679,
author = {Demarco, RS and Stack, BJ and Tang, AM and Voog, J and Sandall, SL and Southall, TD and Brand, AH and Jones, DL},
doi = {10.1016/j.celrep.2022.110679},
journal = {Cell Reports},
pages = {1--20},
title = {Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila},
url = {http://dx.doi.org/10.1016/j.celrep.2022.110679},
volume = {39},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show that Escargot (Esg), a member of the Snail family of transcription factors, regulates the maintenance of somatic cyst stem cells (CySCs) in the Drosophila testis by attenuating the activity of the pro-differentiation insulin receptor (InR) pathway. Esg positively regulates the expression of an antagonist of insulin signaling, ImpL2, while also attenuating the expression of InR. Furthermore, Esg-mediated repression of the InR pathway is required to suppress CySC loss in response to starvation. Given the conservation of Snail-family transcription factors, characterizing the mechanisms by which Esg regulates cell-fate decisions during homeostasis and a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms.
AU  - Demarco,RS
AU  - Stack,BJ
AU  - Tang,AM
AU  - Voog,J
AU  - Sandall,SL
AU  - Southall,TD
AU  - Brand,AH
AU  - Jones,DL
DO  - 10.1016/j.celrep.2022.110679
EP  - 20
PY  - 2022///
SN  - 2211-1247
SP  - 1
TI  - Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2022.110679
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000792114900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.sciencedirect.com/science/article/pii/S2211124722004314?via%3Dihub
UR  - http://hdl.handle.net/10044/1/101130
VL  - 39
ER  -
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