Imperial College London
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Tony D. Southall

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Genetics
 
 
 
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Contact

 

+44 (0)20 7594 5338t.southall

 
 
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Location

 

407Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Southall:2014:10.1016/j.devcel.2014.01.030,
author = {Southall, TD and Davidson, CM and Miller, C and Carr, A and Brand, AH},
doi = {10.1016/j.devcel.2014.01.030},
journal = {Developmental Cell},
pages = {685--696},
title = {Dedifferentiation of neurons precedes tumor gormation in lola mutants},
url = {http://dx.doi.org/10.1016/j.devcel.2014.01.030},
volume = {28},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The ability to reprogram differentiated cells into a pluripotent state has revealed that the differentiated state is plastic and reversible. It is evident, therefore, that mechanisms must be in place to maintain cells in a differentiated state. Transcription factors that specify neuronal characteristics have been well studied, but less is known about the mechanisms that prevent neurons from dedifferentiating to a multipotent, stem cell-like state. Here, we identify Lola as a transcription factor that is required to maintain neurons in a differentiated state. We show that Lola represses neural stem cell genes and cell-cycle genes in postmitotic neurons. In lola mutants, neurons dedifferentiate, turn on neural stem cell genes, and begin to divide, forming tumors. Thus, neurons rather than stem cells or intermediate progenitors are the tumor-initiating cells in lola mutants.
AU  - Southall,TD
AU  - Davidson,CM
AU  - Miller,C
AU  - Carr,A
AU  - Brand,AH
DO  - 10.1016/j.devcel.2014.01.030
EP  - 696
PY  - 2014///
SN  - 1534-5807
SP  - 685
TI  - Dedifferentiation of neurons precedes tumor gormation in lola mutants
T2  - Developmental Cell
UR  - http://dx.doi.org/10.1016/j.devcel.2014.01.030
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333765900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1534580714000719?via%3Dihub
UR  - http://hdl.handle.net/10044/1/18088
VL  - 28
ER  -
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