Imperial College London

DrTriciaTan

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Professor of Practice (Metabolic Medicine & Endocrinology)
 
 
 
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Contact

 

+44 (0)20 3313 8038t.tan

 
 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

109 results found

Pinato DJ, Tan TM, Toussi STK, Ramachandran R, Martin N, Meeran K, Ngo N, Dina R, Sharma Ret al., 2014, An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes, BRITISH JOURNAL OF CANCER, Vol: 110, Pages: 115-122, ISSN: 0007-0920

Journal article

Troke RC, Tan TM, Bloom SR, 2014, The future role of gut hormones in the treatment of obesity., Ther Adv Chronic Dis, Vol: 5, Pages: 4-14, ISSN: 2040-6223

The obesity pandemic presents a significant burden, both in terms of healthcare and economic outcomes, and current medical therapies are inadequate to deal with this challenge. Bariatric surgery is currently the only therapy available for obesity which results in long-term, sustained weight loss. The favourable effects of this surgery are thought, at least in part, to be mediated via the changes of gut hormones such as GLP-1, PYY, PP and oxyntomodulin seen following the procedure. These hormones have subsequently become attractive novel targets for the development of obesity therapies. Here, we review the development of these gut peptides as current and emerging therapies in the treatment of obesity.

Journal article

Tan T, Bloom S, 2013, Gut hormones as therapeutic agents in treatment of diabetes and obesity, CURRENT OPINION IN PHARMACOLOGY, Vol: 13, Pages: 996-1001, ISSN: 1471-4892

Journal article

Tan TM, Bloom SR, 2013, Pancreatic Polypeptide, Handbook of Biologically Active Peptides, Pages: 1294-1299, ISBN: 9780123850959

Book chapter

Troke R, Tan TM, Bloom SR, 2013, PYY, Handbook of Biologically Active Peptides, Pages: 1160-1165, ISBN: 9780123850959

Book chapter

Tharakan G, Chahal H, Tan T, Cousons J, Frankel A, Olbers T, Ahmed Aet al., 2013, A Case Series Illustrating Successful Treatment of Obesity in Renal Transplant Patients with Sleeve Gastrectomies, 18th World Congress of the International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disorders (IFSO), Publisher: SPRINGER, Pages: 1144-1144, ISSN: 0960-8923

Conference paper

Pinato DJ, Tan TM, Toloue-Kalami-Toussi S, Martin N, Ramachandran R, Meeran K, Dina R, Sharma Ret al., 2013, AN EXPRESSION SIGNATURE OF THE ANGIOGENIC RESPONSE IN GASTROINTESTINAL NEUROENDOCRINE TUMOURS: CORRELATION WITH TUMOUR PHENOTYPE AND SURVIVAL OUTCOMES, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A29-A29, ISSN: 0017-5749

Conference paper

Cegla J, Jones B, Seyani L, Papadoulou D, Wynne K, Martin NM, Meeran K, Chapman R, Donaldson M, Goldstone AP, Tan Tet al., 2013, Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism, CLINICAL ENDOCRINOLOGY, Vol: 78, Pages: 738-742, ISSN: 0300-0664

Journal article

Tan TM, Field BCT, McCullough KA, Troke RC, Chambers ES, Salem V, Maffe JG, Baynes KCR, De Silva A, Viardot A, Alsafi A, Frost GS, Ghatei MA, Bloom SRet al., 2013, Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia, DIABETES, Vol: 62, Pages: 1131-1138, ISSN: 0012-1797

Journal article

Kenkre J, Tan T, Bloom S, 2013, Treating the obese diabetic, EXPERT REVIEW OF CLINICAL PHARMACOLOGY, Vol: 6, Pages: 171-183, ISSN: 1751-2433

Journal article

Pinato DJ, Ramachandran R, Toussi STK, Vergine M, Ngo N, Sharma R, Lloyd T, Meeran K, Palazzo F, Martin N, Khoo B, Dina R, Tan TMet al., 2013, Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations, BRITISH JOURNAL OF CANCER, Vol: 108, Pages: 429-437, ISSN: 0007-0920

Journal article

Germain N, Minnion JS, Tan T, Shillito J, Gibbard C, Ghatei M, Bloom Set al., 2013, Analogs of pancreatic polypeptide and peptide YY with a locked PP-fold structure are biologically active, PEPTIDES, Vol: 39, Pages: 6-10, ISSN: 0196-9781

Journal article

Scott R, Tan T, Bloom S, 2013, Gut Hormones and Obesity: Physiology and Therapies, OBESITY, Vol: 91, Pages: 143-194, ISSN: 0083-6729

Journal article

Kauppila E, Allen R, Ifigeneia K, Meades R, Tan T, Barwick T, Soneji N, Al-Nahhas A, Win Zet al., 2012, Short-term Haematological and Biochemical Safety of Lu-177 DOTATATE Therapy, 25th Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S587-S587, ISSN: 1619-7070

Conference paper

Maurice JB, Troke R, Win Z, Ramachandran R, Al-Nahhas A, Naji M, Dhillo W, Meeran K, Goldstone AP, Martin NM, Todd JF, Palazzo F, Tan Tet al., 2012, A comparison of the performance of Ga-68-DOTATATE PET/CT and I-123-MIBG SPECT in the diagnosis and follow-up of phaeochromocytoma and paraganglioma, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 39, Pages: 1266-1270, ISSN: 1619-7070

Journal article

Ali SN, Tan T, Meeran K, Wynne Ket al., 2012, CASE REPORT A man with anxiety, confusion, and red eyes, BRITISH MEDICAL JOURNAL, Vol: 344, ISSN: 1756-1833

Journal article

Sam AH, Troke RC, Tan TM, Bewick GAet al., 2012, The role of the gut/brain axis in modulating food intake, NEUROPHARMACOLOGY, Vol: 63, Pages: 46-56, ISSN: 0028-3908

Journal article

Salem V, Hopkins TG, El-Gayar H, Zac-Varghese S, Goldstone AP, Todd JF, Dhillo W, Field BCT, Martin N, Hatfield E, Donaldson M, Palazzo F, Meeran K, Jackson J, Tan Tet al., 2012, Adrenal venous sampling as a diagnostic procedure for primary hyperaldosteronism: experience from a tertiary referral centre, HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, Vol: 11, Pages: 151-159, ISSN: 1109-3099

Journal article

Jones BJ, Tan T, Bloom SR, 2012, Minireview: Glucagon in Stress and Energy Homeostasis, ENDOCRINOLOGY, Vol: 153, Pages: 1049-1054, ISSN: 0013-7227

Journal article

Tan TM, Field BCT, Minnion JS, Cuenco Shillito J, Chambers ES, Zac-Varghese S, Brindley CJ, Mt-Isa S, Fiorentino F, Ashby D, Ward I, Ghatei MA, Bloom SRet al., 2012, Pharmacokinetics, adverse effects and tolerability of a novel analogue of human pancreatic polypeptide, PP 1420., British Journal of Clinical Pharmacology, Vol: 73, Pages: 232-239

AIMS: The objectives of this phase 1 study were to confirm the tolerability ofsingle ascending subcutaneous doses of PP 1420 in healthy subjects, to assess itsadverse effects and to investigate the drug's pharmacokinetics and doseproportionality.METHODS: This was a double-blind, placebo-controlled, randomized study. Therewere three dosing periods. Each subject (n= 12) was randomized to receive onedose of placebo and two ascending doses of PP 1420, given as a subcutaneousinjection. Blood samples were taken over 24 h to assess pharmacokinetics.Standard safety and laboratory data were collected. The primary endpoint was the tolerability of PP 1420. The secondary endpoint was exposure to PP 1420 asassessed by C(max) and AUC(0,∞).RESULTS: PP 1420 was well tolerated by all subjects with no serious adverseeffects. Following single subcutaneous doses of PP 1420 at 2, 4 and 8 mg to male subjects, C(max) was reached at a median t(max) of approximately 1 h post dose(range 0.32-2.00 h). Thereafter, plasma concentrations of PP 1420 declined withgeometric mean apparent terminal elimination t(1/2) ranging from 2.42-2.61 h(range 1.64-3.95 h) across all dose levels.CONCLUSIONS: Subcutaneous PP 1420 was well tolerated in healthy human subjects atsingle doses between 2-8 mg, with no tolerability issues arising. Where observed,adverse events were not serious, and there was no evidence of a dose-relationshipto frequency of adverse events. The results therefore support the conduct ofclinical trials to investigate efficacy, tolerability and pharmacokinetics duringrepeated dosing.

Journal article

Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BCT, Germain-Zito N, Becker-Pauly C, Ghatei MA, Bloom SR, Murphy KGet al., 2011, A Role for Metalloendopeptidases in the Breakdown of the Gut Hormone, PYY3-36, ENDOCRINOLOGY, Vol: 152, Pages: 4630-4640, ISSN: 0013-7227

Journal article

Maurice JB, Tan T, 2011, A comparison of the performance of 68Ga- DOTATATE PET/CT and 123I- MIBG SPECT in the diagnosis and follow-up of Phaeochromocytoma and Paraganglioma

Poster

Naji M, Zhao C, Welsh SJ, Meades R, Win Z, Ferrarese A, Tan T, Rubello D, Al-Nahhas Aet al., 2011, Ga-68-DOTA-TATE PET vs. I-123-MIBG in Identifying Malignant Neural Crest Tumours, MOLECULAR IMAGING AND BIOLOGY, Vol: 13, Pages: 769-775, ISSN: 1536-1632

Journal article

Sam AH, Tan T, Meeran K, 2011, Insulin-mediated 'pseudoacromegaly', HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, Vol: 10, Pages: 156-161, ISSN: 1109-3099

Journal article

Tharakan G, Tan T, Bloom S, 2011, Emerging therapies in the treatment of 'diabesity': beyond GLP-1, TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 32, Pages: 8-15, ISSN: 0165-6147

Journal article

Carroll RW, Martin JL, Tan T, Goldstone AP, Spalding D, Al-Nahhas A, Todd JF, Meeran K, Frilling Aet al., 2011, Primary Lymph Node Gastrinoma: A Genuine Entity? Two Case Reports and a Review of the Literature, 8th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocine Tumor Disease, Publisher: KARGER, Pages: 18-19, ISSN: 0028-3835

Conference paper

Carroll RW, Tan T, Todd JF, Al-Nahhas A, Bomanji J, Gaze MN, Meeran K, Goldstone APet al., 2011, Lutetium-177 DOTATATE Therapy in the Management of Neuroendocrine Tumors, 8th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocine Tumor Disease, Publisher: KARGER, Pages: 19-19, ISSN: 0028-3835

Conference paper

Zac-Varghese S, Tan T, Bloom SR, 2010, Hormonal Interactions Between Gut and Brain, DISCOVERY MEDICINE, Vol: 10, Pages: 543-552, ISSN: 1539-6509

Journal article

Chhina N, Tan T, Ramachandran R, Goldstone AP, Palazzo F, Al-Nahhas A, Todd JF, Meeran Ket al., 2010, Debulking surgery prior to (177)Lutetium-DOTATATE therapy in management of metastatic bronchial carcinoid, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 15-15, ISSN: 0167-0115

Conference paper

Adjene A, Comninos A, Troke R, Badman MK, Hensman D, Spalding D, Williamson C, Todd JF, Meeran K, Tan Tet al., 2010, The difficulties of managing an insulinoma in pregnancy, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 13-13, ISSN: 0167-0115

Conference paper

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