Imperial College London

DrTriciaTan

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Professor of Practice (Metabolic Medicine & Endocrinology)
 
 
 
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Contact

 

+44 (0)20 3313 8038t.tan

 
 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Izzi-Engbeaya:2018:10.1111/dom.13460,
author = {Izzi-Engbeaya, CN and Comninos, AN and Clarke, S and Abbara, A and Lewis, M and Holmes, E and Nicholson, J and Tan, T and Rutter, G and Dhillo, W},
doi = {10.1111/dom.13460},
journal = {Diabetes, Obesity and Metabolism},
pages = {2800--2810},
title = {The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans},
url = {http://dx.doi.org/10.1111/dom.13460},
volume = {20},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - AimsTo investigate the effect of kisspeptin on glucosestimulated insulin secretion and appetite in humans.Materials and methodsIn 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m−2), we compared the effects of 1 nmol kg−1 h−1 kisspeptin versus vehicle administration on glucosestimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed the effect of kisspeptin on glucosestimulated insulin secretion in vitro in human pancreatic islets and a human βcell line (EndoCβH1 cells).ResultsKisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucosestimulated insulin secretion from human islets and a human pancreatic cell line in vitro. In addition, kisspeptin administration did not alter gut hormones, appetite or food intake in healthy men.ConclusionsCollectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptinbased therapies for reproductive and potentially metabolic conditions.
AU - Izzi-Engbeaya,CN
AU - Comninos,AN
AU - Clarke,S
AU - Abbara,A
AU - Lewis,M
AU - Holmes,E
AU - Nicholson,J
AU - Tan,T
AU - Rutter,G
AU - Dhillo,W
DO - 10.1111/dom.13460
EP - 2810
PY - 2018///
SN - 1462-8902
SP - 2800
TI - The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans
T2 - Diabetes, Obesity and Metabolism
UR - http://dx.doi.org/10.1111/dom.13460
UR - http://hdl.handle.net/10044/1/61939
VL - 20
ER -