Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Professor of Practice (Metabolic Medicine & Endocrinology)



+44 (0)20 3313 8038t.tan




6N6ECommonwealth BuildingHammersmith Campus






BibTex format

author = {Hope, DCD and Tan, TMM and Bloom, SR},
doi = {10.3389/fendo.2018.00442},
journal = {Frontiers in Endocrinology},
title = {No guts, no loss: Toward the ideal treatment for obesity in the twenty-first century},
url = {},
volume = {9},
year = {2018}

RIS format (EndNote, RefMan)

AB - Over the last century, our knowledge of the processes which control appetite and weight regulation has developed significantly. The understanding of where gut hormones fit into the control of energy homeostasis in addition to the rapid advancement of pharmacotherapeutics has paved the way for the development of novel gut hormone analogs to target weight loss. Currently, bariatric surgery remains the most efficacious treatment for obesity. The emergence of gut hormone analogs may provide a useful non-surgical addition to the armamentarium in treating obesity. Simply targeting single gut hormone pathways may be insufficiently efficacious, and combination/multiple-agonist approaches may be necessary to obtain the results required for clear clinical impact.
AU - Hope,DCD
AU - Tan,TMM
AU - Bloom,SR
DO - 10.3389/fendo.2018.00442
PY - 2018///
SN - 1664-2392
TI - No guts, no loss: Toward the ideal treatment for obesity in the twenty-first century
T2 - Frontiers in Endocrinology
UR -
UR -
VL - 9
ER -