Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Professor of Practice (Metabolic Medicine & Endocrinology)



+44 (0)20 3313 8038t.tan




6N6ECommonwealth BuildingHammersmith Campus






BibTex format

author = {Alexiadou, K and Anyiam, O and Tan, T},
doi = {10.1111/jne.12664},
journal = {Journal of Neuroendocrinology},
pages = {e12664--e12664},
title = {Cracking the combination: gut hormones for the treatment of obesity and diabetes},
url = {},
volume = {31},
year = {2019}

RIS format (EndNote, RefMan)

AB - Obesity and type 2 diabetes are a veritable global pandemic. There is an imperative to develop new therapies for these conditions that can be delivered at scale to patients, which deliver effective and titratable weight loss, amelioration of diabetes, prevention of diabetic complications and improvements in cardiovascular health. Although agents based on glucagon-like peptide-1 (GLP-1) are now in routine use for diabetes and obesity, the limited efficacy of such drugs means that newer agents are required. By combining the effects of GLP-1 with other gut and metabolic hormones such as glucagon (GCG), oxyntomodulin, glucose-dependent insulinotropic peptide (GIP) and peptide YY, we may obtain improved weight loss, increased energy expenditure and improved metabolic profiles. Drugs based on dual agonism of GLP1R/GCGR and GLP1R/GIPR are being actively developed in clinical trials. Triple agonism, for example with GLPR1/GCGR/GIPR unimolecular agonists or using GLP-1/oxyntomodulin/peptide YY, is also being explored. Multi-agonist drugs seem set to deliver the next generation of therapies for diabetes and obesity soon. This article is protected by copyright. All rights reserved.
AU - Alexiadou,K
AU - Anyiam,O
AU - Tan,T
DO - 10.1111/jne.12664
EP - 12664
PY - 2019///
SN - 0953-8194
SP - 12664
TI - Cracking the combination: gut hormones for the treatment of obesity and diabetes
T2 - Journal of Neuroendocrinology
UR -
UR -
UR -
UR -
VL - 31
ER -