Imperial College London
Alternate

ProfessorTriciaTan

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Metabolic Medicine and Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 8038t.tan

 
 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clarke:2021:clinem/dgab349,
author = {Clarke, S and Phylactou, M and Patel, B and Mills, E and Muzi, B and Izzi-Engbeaya, C and Choudhury, S and Khoo, B and Meeran, K and Comninos, A and Abbara, A and Tan, T and Dhillo, W},
doi = {clinem/dgab349},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {2208--2220},
title = {Normal adrenal and thyroid function in patients who survive COVID-19 infection},
url = {http://dx.doi.org/10.1210/clinem/dgab349},
volume = {106},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ContextThe COVID-19 pandemic continues to exert an immense burden on global health services. Moreover, up to 63% of patients experience persistent symptoms, including fatigue, after acute illness. Endocrine systems are vulnerable to the effects of COVID-19 as many glands express the ACE2 receptor, used by the SARS-CoV-2 virion for cellular access. However, the effects of COVID-19 on adrenal and thyroid gland function after acute COVID-19 remain unknown. ObjectivesOur objectives were to evaluate adrenal and thyroid gland function in COVID-19 survivors.  DesignA prospective, observational study was undertaken. SettingClinical Research Facility, Imperial College NHS Healthcare Trust. ParticipantsSeventy patients ≥ 18 years at least 3 months after diagnosis of COVID-19 were included. InterventionParticipants attended a research study visit (08:00-09:30), during which a short Synacthen test (250 µg IV bolus), and thyroid function assessments were performed.ResultsAll patients had a peak cortisol ≥450 nmol/l after Synacthen, consistent with adequate adrenal reserve. Basal and peak serum cortisol did not differ according to disease severity or history of dexamethasone treatment during COVID-19. There was no difference in baseline or peak cortisol after Synacthen or in thyroid function tests, or thyroid status, in patients with fatigue (n=44) compared to those without (n=26).ConclusionsAdrenal and thyroid function ≥3 months after presentation with COVID-19 was preserved. Whilst a significant proportion of patients experienced persistent fatigue, their symptoms were not accounted for by alterations in adrenal or thyroid function. These findings have important implications for the clinical care of patients after COVID-19.
AU  - Clarke,S
AU  - Phylactou,M
AU  - Patel,B
AU  - Mills,E
AU  - Muzi,B
AU  - Izzi-Engbeaya,C
AU  - Choudhury,S
AU  - Khoo,B
AU  - Meeran,K
AU  - Comninos,A
AU  - Abbara,A
AU  - Tan,T
AU  - Dhillo,W
DO  - clinem/dgab349
EP  - 2220
PY  - 2021///
SN  - 0021-972X
SP  - 2208
TI  - Normal adrenal and thyroid function in patients who survive COVID-19 infection
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/clinem/dgab349
UR  - https://academic.oup.com/jcem/article/106/8/2208/6278132
UR  - http://hdl.handle.net/10044/1/88516
VL  - 106
ER  -
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