Imperial College London
Alternate

ProfessorTriciaTan

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Metabolic Medicine and Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 8038t.tan

 
 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Salem:2021:10.1111/dme.4_14556,
author = {Salem, V and Demetriou, L and Behary, P and Alexiadou, K and Miras, A and Scoltz, S and Purkayastha, S and Ahmed, S and Dhillo, W and Tan, T},
doi = {10.1111/dme.4_14556},
pages = {1--1},
publisher = {Wiley},
title = {Weight loss by low-calorie diet versus gastric bypass surgery in people with diabetes results in divergent brain activation patterns which may explain differences in long-term outcomes: an FMRI study},
url = {http://dx.doi.org/10.1111/dme.4_14556},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Objective: Clinically significant weight loss can produce remission of type 2 diabetes. Bariatric surgery (specifically, Roux-en-Y gastric bypass, RYGB) produces durable weight loss that translates into reductions in mortality. In contrast, weight regain is very common after very low-calorie diets (VLCD). No study has investigated longitudinal changes in brain activity using functional MRI in patients living with obesity and prediabetes/type 2 diabetes to explain this difference.Methods: Visual food cue responses and resting state connectivity was assessed with functional MRI pre- and post-intervention and compared between 16 participants who underwent gastric bypass surgery and 19 age, gender, and disease stage matched participants who undertook a VLCD for 4 weeks.Results: Brain responses to RYGB-induced weight loss diverge from those induced by VLCD in three domains: (i) dieting resulted in increased responsiveness to visual food cues in reward areas whereas after RYGB this was reduced; (ii) dieting therefore engaged greater activation of brain regions involved in cognitive control, associated with the need to exercise increased restraint over eating; and (iii) a homeostatic appetitive system (centred on the hypothalamus) was better engaged following RYGB-induced weight loss than dieting.Conclusion: This study provides a holistic view of multiple divergent brain responses to different methods of weight loss in patients with diabetes, which may explain weight regain after a short-term VLCD in contrast with the enduring weight loss after RYGB.
AU  - Salem,V
AU  - Demetriou,L
AU  - Behary,P
AU  - Alexiadou,K
AU  - Miras,A
AU  - Scoltz,S
AU  - Purkayastha,S
AU  - Ahmed,S
AU  - Dhillo,W
AU  - Tan,T
DO  - 10.1111/dme.4_14556
EP  - 1
PB  - Wiley
PY  - 2021///
SN  - 0742-3071
SP  - 1
TI  - Weight loss by low-calorie diet versus gastric bypass surgery in people with diabetes results in divergent brain activation patterns which may explain differences in long-term outcomes: an FMRI study
UR  - http://dx.doi.org/10.1111/dme.4_14556
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000641699200029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/dme.4_14556
UR  - http://hdl.handle.net/10044/1/89284
ER  -
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