Imperial College London
Alternate

ProfessorTriciaTan

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Metabolic Medicine and Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 8038t.tan

 
 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jones:2022:clinem/dgab608,
author = {Jones, B and Sands, C and Alexiadou, K and Minnion, J and Tharakan, G and Behary, P and Ahmed, A and Purkayastha, S and Lewis, M and Bloom, S and Li, J and Tan, T},
doi = {clinem/dgab608},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {e767--e782},
title = {The metabolomic effects of tripeptide gut hormone infusion compared to Roux-en-Y gastric bypass and caloric restriction},
url = {http://dx.doi.org/10.1210/clinem/dgab608},
volume = {107},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Context: The gut-derived peptide hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY) are regulators of energy intake and glucose homeostasis, and are thought to contribute to the glucose-lowering effects of bariatric surgery. Objective: To establish the metabolomic effects of a combined infusion of GLP-1, OXM and PYY (tripeptide “GOP”) in comparison to a placebo infusion, Roux-en-Y gastric bypass (RYGB) surgery, and a very low-calorie diet (VLCD). Design and setting: Sub-analysis of a single-blind, randomised, placebo-controlled study of GOP infusion (ClinicalTrials.gov NCT01945840), including VLCD and RYGB comparator groups. Patients and interventions: 25 obese patients with type 2 diabetes or prediabetes were randomly allocated to receive a 4-week subcutaneous infusion of GOP (n=14) or 0.9% saline control (SAL; n=11). An additional 22 patients followed a VLCD, and 21 underwent RYGB surgery. Main outcome measures: Plasma and urine samples collected at baseline and 4 weeks into each intervention were subjected to cross-platform metabolomic analysis, followed by unsupervised and supervised modelling approaches to identify similarities and differences between the effects of each intervention. Results: Aside from glucose, very few metabolites were affected by GOP, contrasting with major metabolomic changes seen with VLCD and RYGB. Conclusions: Treatment with GOP provides a powerful glucose-lowering effect but does not replicate the broader metabolomic changes seen with VLCD and RYGB. The contribution of these metabolomic changes to the clinical benefits of RYGB remains to be elucidated.
AU  - Jones,B
AU  - Sands,C
AU  - Alexiadou,K
AU  - Minnion,J
AU  - Tharakan,G
AU  - Behary,P
AU  - Ahmed,A
AU  - Purkayastha,S
AU  - Lewis,M
AU  - Bloom,S
AU  - Li,J
AU  - Tan,T
DO  - clinem/dgab608
EP  - 782
PY  - 2022///
SN  - 0021-972X
SP  - 767
TI  - The metabolomic effects of tripeptide gut hormone infusion compared to Roux-en-Y gastric bypass and caloric restriction
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/clinem/dgab608
UR  - https://academic.oup.com/jcem/article/107/2/e767/6359898
UR  - http://hdl.handle.net/10044/1/91275
VL  - 107
ER  -
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