Imperial College London
Alternate

ProfessorTriciaTan

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Metabolic Medicine and Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 8038t.tan

 
 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Scott:2018:10.1016/j.peptides.2018.04.008,
author = {Scott, R and Minnion, J and Tan, T and Bloom, SR},
doi = {10.1016/j.peptides.2018.04.008},
journal = {Peptides},
pages = {70--77},
title = {Oxyntomodulin analogue increases energy expenditure via the glucagon receptor},
url = {http://dx.doi.org/10.1016/j.peptides.2018.04.008},
volume = {104},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The gut hormone oxyntomodulin (OXM) causes weight loss by reducing appetite and increasing energy expenditure. Several analogues are being developed to treat obesity. Exactly how oxyntomodulin works, however, remains controversial. OXM can activate both glucagon and GLP-1 receptors but no specific receptor has been identified. It is thought that the anorectic effect occurs predominantly through GLP-1 receptor activation but, to date, it has not been formally confirmed which receptor is responsible for the increased energy expenditure. We developed OX-SR, a sustained-release OXM analogue. It produces a significant and sustained increase in energy expenditure in rats as measured by indirect calorimetry. We now show that this increase in energy expenditure occurs via activation of the glucagon receptor. Blockade of the GLP-1 receptor with Exendin 9-39 does not block the increase in oxygen consumption caused by OX-SR. However, when activity at the glucagon receptor is lost, there is no increase in energy expenditure. Glucagon receptor activity therefore appears to be essential for OX-SR's effects on energy expenditure. The development of future 'dual agonist' analogues will require careful balancing of GLP-1 and glucagon receptor activities to obtain optimal effects.
AU  - Scott,R
AU  - Minnion,J
AU  - Tan,T
AU  - Bloom,SR
DO  - 10.1016/j.peptides.2018.04.008
EP  - 77
PY  - 2018///
SN  - 0196-9781
SP  - 70
TI  - Oxyntomodulin analogue increases energy expenditure via the glucagon receptor
T2  - Peptides
UR  - http://dx.doi.org/10.1016/j.peptides.2018.04.008
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29680267
UR  - http://hdl.handle.net/10044/1/58992
VL  - 104
ER  -
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