Publications
165 results found
Beineke A, Markus S, Borlak J, et al., 2008, Increase of Pro-Inflammatory Cytokine Expression in Non-Demyelinating Early Cerebral Lesions in Nervous Canine Distemper, VIRAL IMMUNOLOGY, Vol: 21, Pages: 401-410, ISSN: 0882-8245
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- Citations: 23
Thum T, 2008, Cardiac dissonance without conductors - How Dicer depletion provokes chaos in the heart, CIRCULATION, Vol: 118, Pages: 1524-1527, ISSN: 0009-7322
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- Citations: 14
Thum T, Catalucci D, Bauersachs J, 2008, MicroRNAs: novel regulators in cardiac development and disease, CARDIOVASCULAR RESEARCH, Vol: 79, Pages: 562-570, ISSN: 0008-6363
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- Citations: 287
Akashi YJ, Palus S, Datta R, et al., 2008, No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 137, Pages: 267-275, ISSN: 0167-5273
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- Citations: 36
Fraccarollo D, Widder JD, Galuppo P, et al., 2008, Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction, CIRCULATION, Vol: 118, Pages: 818-827, ISSN: 0009-7322
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- Citations: 95
Werner C, Hanhoun M, Widmann T, et al., 2008, Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 52, Pages: 470-482, ISSN: 0735-1097
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- Citations: 174
Thum T, Borlak J, 2008, LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 19456-19464, ISSN: 0021-9258
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- Citations: 50
Diller G-P, van Eijl S, Okonko DO, et al., 2008, Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension, CIRCULATION, Vol: 117, Pages: 3020-3030, ISSN: 0009-7322
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- Citations: 171
Wenzel P, Daiber A, Oelze M, et al., 2008, Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus, ATHEROSCLEROSIS, Vol: 198, Pages: 65-76, ISSN: 0021-9150
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- Citations: 106
Fleissner F, Thum T, 2008, The IGF-1 receptor as a therapeutic target to improve endothelial progenitor cell function, MOLECULAR MEDICINE, Vol: 14, Pages: 235-237, ISSN: 1076-1551
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- Citations: 13
Thum T, Bauersachs J, 2008, Letter by Thum et al regarding article, "Oxidant Stress Impairs In Vivo Reendothelialization Capacity of Endothelial Progenitor Cells From Patients With Type 2 Diabetes Mellitus:: Restoration by the Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone", CIRCULATION, Vol: 117, Pages: E185-E185, ISSN: 0009-7322
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- Citations: 2
Thum T, Borlak J, 2008, Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes, ARCHIVES OF TOXICOLOGY, Vol: 82, Pages: 89-101, ISSN: 0340-5761
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- Citations: 25
Okonko DO, Grzeslo A, Witkowski T, et al., 2008, Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 51, Pages: 103-112, ISSN: 0735-1097
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- Citations: 410
Jakob M, Thum T, 2008, Recent patents on cardiovascular stem cells., Recent Pat Cardiovasc Drug Discov, Vol: 3, Pages: 59-72
Chronic heart failure has emerged as a leading cause of morbidity and mortality worldwide. Conceptually, replacement of akinetic scar tissue by viable myocardium and improvement of neovascularization should improve cardiac function and impede progressive left ventricular remodelling. Experimental and clinical studies suggest that transfer or mobilization of stem and progenitor cells can have a favourable impact on tissue perfusion and contractile cardiac performance. The aim of the present review was to screen various available patent data bases to give an overview on different patent applications of cell-based and non-cell based therapies in regenerative cardiovascular medicine. The first part describes cell based methods and use of growth factors to improve cardiovascular function. Secondly, patents on methods to improve angiogenesis, re-endothelialization and vascular function are presented. Finally, we describe patents describing methods for improved differentiation of stem cells to cardiovascular cells, including the generation of cardiomyocytes from embryonic or adult stem cells. A systematic overview on the current patent situation about use of stem cells in cardiovascular medicine should facilitate future decision making in the development of novel therapeutic strategies in regenerative medicine.
Diller GP, Okonko D, van Eijl S, et al., 2007, Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension, CIRCULATION, Vol: 116, Pages: 661-662, ISSN: 0009-7322
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