Imperial College London
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DrTeresaThurston

Faculty of Medicine, Department of Infectious Disease

Senior Lecturer in Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 3072t.thurston

 
 
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Location

 

2.40Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mak:2021:10.3389/fcimb.2021.608860,
author = {Mak, H and Thurston, T},
doi = {10.3389/fcimb.2021.608860},
journal = {Frontiers in Cellular and Infection Microbiology},
title = {Interesting biochemistries in the structure and function of bacterial effectors},
url = {http://dx.doi.org/10.3389/fcimb.2021.608860},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bacterial effector proteins, delivered into host cells by specialized multiprotein secretion systems, are a key mediator of bacterial pathogenesis. Following delivery, they modulate a range of host cellular processes and functions. Strong selective pressures have resulted in bacterial effectors evolving unique structures that can mimic host protein biochemical activity or enable novel and distinct biochemistries. Despite the protein structure-function paradigm, effectors from different bacterial species that share biochemical activities, such as the conjugation of ubiquitin to a substrate, do not necessarily share structural or sequence homology to each other or the eukaryotic proteins that carry out the same function. Furthermore, some bacterial effectors have evolved structural variations to known protein folds which enable different or additional biochemical and physiological functions. Despite the overall low occurrence of intrinsically disordered proteins or regions in prokaryotic proteomes compared to eukaryotes proteomes, bacterial effectors appear to have adopted intrinsically disordered regions that mimic the disordered regions of eukaryotic signaling proteins. In this review, we explore examples of the diverse biochemical properties found in bacterial effectors that enable effector-mediated interference of eukaryotic signaling pathways and ultimately support pathogenesis. Despite challenges in the structural and functional characterisation of effectors, recent progress has been made in understanding the often unusual and fascinating ways in which these virulence factors promote pathogenesis. Nevertheless, continued work is essential to reveal the array of remarkable activities displayed by effectors.
AU  - Mak,H
AU  - Thurston,T
DO  - 10.3389/fcimb.2021.608860
PY  - 2021///
SN  - 2235-2988
TI  - Interesting biochemistries in the structure and function of bacterial effectors
T2  - Frontiers in Cellular and Infection Microbiology
UR  - http://dx.doi.org/10.3389/fcimb.2021.608860
UR  - http://hdl.handle.net/10044/1/86853
VL  - 11
ER  -
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