Imperial College London

DrTimothyWatts

Faculty of MedicineNational Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

t.watts Website

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

26 results found

Tan KL, Bisconti I, Leck C, Billahalli T, Barnett S, Rajakulasingam K, Watts TJet al., 2020, Bullous fixed drug eruption induced by fluconazole: Importance of multi-site lesional patch testing., Contact Dermatitis

Journal article

Watts TJ, 2020, Diagnostic Challenge of Investigating Drug Hypersensitivity: Time Intervals and Clinical Phenotypes., J Allergy Clin Immunol Pract, Vol: 8, Pages: 2715-2717

Journal article

Fiengo L, Gwozdz A, Tincknell L, Harvey V, Watts T, Black Set al., 2020, VenaSeal closure despite allergic reaction to n-butyl cyanoacrylate., J Vasc Surg Cases Innov Tech, Vol: 6, Pages: 269-271, ISSN: 2468-4287

The VenaSeal closure system (Medtronic, Minneapolis, Minn) is a nonthermal, minimally invasive method for the treatment of superficial venous insufficiency using a proprietary n-butyl cyanoacrylate. We report the case of a 45-year-old woman who underwent right great saphenous vein closure with VenaSeal and subsequently had a biphasic reaction to n-butyl cyanoacrylate, confirmed on patch testing that had negative results for other cyanoacrylates. Despite the initial allergic response, which settled with antihistamines, follow-up duplex ultrasound imaging confirmed successful great saphenous vein closure, and the affected vein remained in situ without further complication.

Journal article

Yung CC, Watts TJ, Haque R, 2020, Successful desensitization to metronidazole in a patient with generalized fixed drug eruption., J Allergy Clin Immunol Pract, Vol: 8, Pages: 769-771.e1

Journal article

Watts TJ, Thursfield D, Haque R, 2019, Patch testing for the investigation of nonimmediate cutaneous adverse drug reactions: A prospective single center study, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 7, Pages: 2941-+, ISSN: 2213-2198

Journal article

Li PH, Watts TJ, Chung H-Y, Lau C-Set al., 2019, Fixed Drug Eruption to Biologics and Role of Lesional Patch Testing, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 7, Pages: 2398-2399, ISSN: 2213-2198

Journal article

Chean LQ, Li PH, Watts TJ, Thomas I, Ue KL, Caballero MR, Rutkowski K, Till SJ, Pillai P, Haque Ret al., 2019, Identifying Low-Risk Beta-Lactam Allergy Patients in a UK Tertiary Centre, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 7, Pages: 2173-+, ISSN: 2213-2198

Journal article

Li PH, Siew LQC, Thomas I, Watts TJ, Ue KL, Rutkowski K, Lau C-Set al., 2019, Beta-lactam allergy in Chinese patients and factors predicting genuine allergy., World Allergy Organ J, Vol: 12, ISSN: 1939-4551

Introduction: Beta-lactams (BL) are the most frequently reported drug allergy, but the vast majority of patients are found not to be genuinely allergic after evaluation. Few studies have investigated the clinical predictors of genuine BL allergy, and the prevalence in hospitalized Chinese patients is unknown. Methods: Patients admitted to a tertiary hospital in Hong Kong (HK) were analyzed to identify the prevalence and factors associated with the presence of BL allergy labels among hospitalized Chinese patients. A combined cohort of patients having completed allergy investigation for suspected BL allergies in the United Kingdom (UK) and HK were analyzed to identify predictors of genuine allergy. Results: The prevalence of BL allergy labels in hospitalized HK Chinese was 5%, which was associated with female gender and concomitant non-BL antibiotic allergy labels. The rate of genuine BL allergy patients referred for suspected allergies in the UK and HK cohort was only 14%. History of anaphylaxis and interval of less than a year since the index reaction were independent clinical predictors of genuine BL allergy. The negative predictive value of penicillin skin testing was 90%, confirming the need for drug provocation testing after negative skin testing. There was a high rate of confirmed piperacillin-tazobactam allergy. Discussion: The estimated true prevalence of genuine BL allergy in hospitalized HK Chinese is around 0.5%. This high rate of BL mislabeling highlights the need for comprehensive allergy evaluation and screening. History of anaphylaxis and duration since the index reaction are important predictors of genuine allergy. Piperacillin-tazobactam allergy may pose a unique challenge in this population with a high prevalence of suspected allergies, surging antibiotic resistance, and lack of testing available.

Journal article

Watts TJ, Thursfield D, Haque R, 2019, Allergic contact dermatitis caused by VenaSeal tissue adhesive, CONTACT DERMATITIS, Vol: 80, Pages: 393-+, ISSN: 0105-1873

Journal article

Watts TJ, 2019, Investigating Nonimmediate Drug Eruptions: Diagnostic Benefit of a Structured Approach, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 7, Pages: 1324-1326, ISSN: 2213-2198

Journal article

Watts TJ, Thursfield D, Haque R, 2019, Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 7, Pages: 651-652, ISSN: 2213-2198

Journal article

Thomas I, Siew LQC, Watts TJ, Haque Ret al., 2019, Seaweed allergy, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 7, Pages: 714-715, ISSN: 2213-2198

Journal article

Watts TJ, Watts S, Thursfield D, Haque Ret al., 2019, A Patch Testing Initiative for the Investigation of Allergic Contact Dermatitis in a UK Allergy Practice: A Retrospective Study, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 7, Pages: 89-95, ISSN: 2213-2198

Journal article

Li PH, Wagner A, Thomas I, Watts TJ, Rutkowski R, Rutkowski Ket al., 2018, Steroid Allergy: Clinical Features and the Importance of Excipient Testing in a Diagnostic Algorithm, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 6, Pages: 1655-1661, ISSN: 2213-2198

Journal article

Watts TJ, Li PH, Haque R, 2018, DRESS Syndrome due to benzylpenicillin with cross-reactivity to amoxicillin, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 6, Pages: 1766-1768, ISSN: 2213-2198

Journal article

Watts TJ, Haque R, 2018, DRESS Syndrome Induced by Ranitidine, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 6, Pages: 1030-1031, ISSN: 2213-2198

Journal article

Li PH, Watts TJ, Lui M-S, Lau C-S, Chung H-Yet al., 2018, Recall Urticaria in Adalimumab Hypersensitivity, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 6, Pages: 1032-1033, ISSN: 2213-2198

Journal article

Li PH, Rutkowski K, Kennard L, Sellaturay P, Watts TJ, Haque R, Wagner Aet al., 2018, Challenge-confirmed peanut allergy in older patients: Performance of skin tests, specific immunoglobulin E, and ara h 2, ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Vol: 120, Pages: 334-335, ISSN: 1081-1206

Journal article

Watts TJ, Li PH, Ue KL, Haque Ret al., 2018, Chronic Allergic Contact Dermatitis Due to Chlorhexidine, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 6, Pages: 254-255, ISSN: 2213-2198

Journal article

Watts TJ, Li PH, Thomas I, Haque Ret al., 2017, Occupational Allergic Contact Dermatitis due to Multiple Tropical Plant Species, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 5, Pages: 1411-1412, ISSN: 2213-2198

Journal article

Li PH, Gunawardana N, Thomas I, Ue KL, Siew L, Watts TJ, Bintcliffe K, Haque R, Rutkowski K, Skypala I, Till SJet al., 2017, Sesame allergy in adults Investigation and outcomes of oral food challenges, ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Vol: 119, Pages: 285-287, ISSN: 1081-1206

Journal article

Watts TJ, 2017, Severe delayed-type hypersensitivity to chloramphenicol with systemic reactivation during intradermal testing, ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Vol: 118, Pages: 644-645, ISSN: 1081-1206

Journal article

Watts TJ, 2010, The in vitro hemolytic effect of diltiazem on erythrocytes exposed to varying osmolarity, TOXICOLOGY MECHANISMS AND METHODS, Vol: 20, Pages: 435-439, ISSN: 1537-6524

Journal article

Watts TJ, 2008, The pathogenesis of autism., Clin Med Pathol, Vol: 1, Pages: 99-103, ISSN: 1178-1181

Autism is well known as a complex developmental disorder with a seemingly confusing and uncertain pathogenesis. The definitive mechanisms that promote autism are poorly understood and mostly unknown, yet available theories do appear to focus on the disruption of normal cerebral development and its subsequent implications on the functional brain unit. This mini-review aims solely to discuss and evaluate the most prominent current theories regarding the pathogenesis of autism. The main conclusion is that although there is not a clear pathway of mechanisms directed towards a simple pathogenesis and an established link to autism on the symptomatic level; there are however several important theories (neural connectivity, neural migration, excitatory-inhibitory neural activity, dendritic morphology, neuroimmune; calcium signalling and mirror neurone) which appear to offer an explanation to how autism develops. It seems probable that autism's neurodevelopmental defect is 'multi-domain' in origin (rather than a single anomaly) and is hence distributed across numerous levels of study (genetic, immunopathogenic, etc.). A more definitive understanding of the pathogenesis could facilitate the development of better treatments for this complex psychiatric disorder.

Journal article

Watts TJ, Handy RD, 2007, The haemolytic effect of verapamil on erythrocytes exposed to varying osmolarity, TOXICOLOGY IN VITRO, Vol: 21, Pages: 835-839, ISSN: 0887-2333

Journal article

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