Summary
Current Role
Tamlyn is currently a Teaching Fellow within the National Heart and Lung Institute, with responsibilities for developing and delivering teaching on the intercalated BSc in Remote Medicine covering human physiology in extremes and healthcare delivery in remote environments, as well as delivering teaching on other courses within the NHLI (such as the MSc in Cardiovascular and Respiratory Healthcare) and MBBS Phase 1 (such as projects for year 2 students during Clincal Research and Innovation).
Biography
He was previously a research associate at Kings’ College London, working under an Arthritis UK project grant to develop two-photon intravital imaging of Ptpn22 mutant T cells in lymph nodes and sites of inflammation, in collaboration with Professor James Brewer at the University of Glasgow.
He completed a 4-year MSc PhD studentship from the MRC and Asthma UK Centre for Allergic Mechanisms in Asthma, supervised by Professor Sebastian Johnston. Previously he gained an undergraduate degree in Immunology from the University of Bristol, afterwards working as a scientist within both the NHS and industry before returning to academia.
His PhD thesis studied the role of Th17 cells and their definitive cytokine IL-17 in rhinovirus-induced exacerbations of asthma. IL-17 is increased in the lungs of asthmatics, and correlates with disease severity. The presence of IL-17 in the lung increases neutrophil recruitment in response to rhinovirus infection, resulting in greater inflammation and loss of lung function without improving antiviral responses, providing a potential theraputic target, especially for steroid-resistant asthma.
After completing his PhD, Tamlyn gained an MRC Centenary Early Career Award, which allowed him to complete research projects leading on from his thesis. As well as carrying on further research projects investigating mechanisms of IL-17–driven asthma, he was also involved in a clinical trial of allergic rhinitis therapy in collaboration with the Imperial Clinical Respiratory Research Unit (ICRRU), using novel techniques to interrogate changes in the allergic response.
Other Roles
Aside from his PhD, as a student Tamlyn was also on the organising committee for the Young Life Scientists' Symposium 2010, which brought together over 120 students and young post-docs in asthma and allergy research to present talks and posters, as well as talks from the keynote speakers Polly Matzinger and Bart Lambrecht.
Publications
Journals
Shannon MJ, Pineau J, Griffie J, et al., 2020, Differential nanoscale organisation of LFA-1 modulates T-cell migration, Journal of Cell Science, Vol:133, ISSN:0021-9533
Alfituri OA, Ajibola O, Brewer JM, et al., 2019, Effects of host-derived chemokines on the motility and viability of <i>Trypanosoma brucei</i>, Parasite Immunology, Vol:41, ISSN:0141-9838
Glanville N, Peel TJ, Schröder A, et al., 2016, Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection, Plos Pathogens, Vol:12, ISSN:1553-7366
McLean GR, Walton RP, Shetty S, et al., 2013, Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1 (vol 95, pg 193, 2012), Antiviral Research, Vol:97, ISSN:0166-3542, Pages:381-381
Medalla GA, Moonot P, Peel T, et al., 2009, Cost-Benefit Comparison of the Oxford Knee Score and the American Knee Society Score in Measuring Outcome of Total Knee Arthroplasty, Journal of Arthroplasty, Vol:24, ISSN:0883-5403, Pages:652-656