6 results found
Shannon MJ, Pineau J, Griffie J, et al., 2020, Differential nanoscale organisation of LFA-1 modulates T-cell migration, JOURNAL OF CELL SCIENCE, Vol: 133, ISSN: 0021-9533
Alfituri OA, Ajibola O, Brewer JM, et al., 2019, Effects of host-derived chemokines on the motility and viability of Trypanosoma brucei, PARASITE IMMUNOLOGY, Vol: 41, ISSN: 0141-9838
Glanville N, Peel TJ, Schröder A, et al., 2016, Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection, PLOS Pathogens, Vol: 12, ISSN: 1553-7366
Current understanding of adaptive immune, particularly T cell, responses to human rhinoviruses (RV) is limited. Memory T cells are thought to be of a primarily T helper 1 type, but both T helper 1 and T helper 2 memory cells have been described, and heightened T helper 2/ lessened T helper 1 responses have been associated with increased RV-induced asthma exacerbation severity. We examined the contribution of T helper 1 cells to RV-induced airways inflammation using mice deficient in the transcription factor T-Box Expressed In T Cells (Tbet), a critical controller of T helper 1 cell differentiation. Using flow cytometry we showed that Tbet deficient mice lacked the T helper 1 response of wild type mice and instead developed mixed T helper 2/T helper 17 responses to RV infection, evidenced by increased numbers of GATA binding protein 3 (GATA-3) and RAR-related orphan receptor gamma t (RORγt), and interleukin-13 and interleukin-17A expressing CD4+ T cells in the lung. Forkhead box P3 (FOXP3) and interleukin-10 expressing T cell numbers were unaffected. Tbet deficient mice also displayed deficiencies in lung Natural Killer, Natural Killer T cell and γδT cell responses, and serum neutralising antibody responses. Tbet deficient mice exhibited pronounced airways eosinophilia and mucus production in response to RV infection that, by utilising a CD4+ cell depleting antibody, were found to be T helper cell dependent. RV induction of T helper 2 and T helper 17 responses may therefore have an important role in directly driving features of allergic airways disease such as eosinophilia and mucus hypersecretion during asthma exacerbations.
McLean GR, Walton RP, Shetty S, et al., 2013, Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1 (vol 95, pg 193, 2012), ANTIVIRAL RESEARCH, Vol: 97, Pages: 381-381, ISSN: 0166-3542
Medalla GA, Moonot P, Peel T, et al., 2009, Cost-Benefit Comparison of the Oxford Knee Score and the American Knee Society Score in Measuring Outcome of Total Knee Arthroplasty, JOURNAL OF ARTHROPLASTY, Vol: 24, Pages: 652-656, ISSN: 0883-5403
Changulani M, Kalairajah Y, Peel T, et al., 2008, The relationship between obesity and the age at which hip and knee replacement is undertaken, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, Vol: 90B, Pages: 360-363, ISSN: 0301-620X
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