Imperial College London
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DrTheresaPage

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Research Fellow
 
 
 
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Contact

 

theresa.page Website

 
 
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Location

 

9N4Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Page:1997,
author = {Page, TH and Lali, FV and Groome, N and Foxwell, BM},
journal = {J Immunol},
pages = {5727--5735},
title = {Association of the common gamma-chain with the human IL-7 receptor is modulated by T cell activation.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/9190922},
volume = {158},
year = {1997}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IL-7 acts on both resting and activated T cells. The functional IL-7R is reported to consist of two subunits, the ligand binding IL-7R and the common gamma-chain (gamma c chain), where IL-7R:gamma c chain association is driven solely by ligand binding. However, we now demonstrate that in primary T cells this event is also controlled by cellular activation. We show that IL-7R:gamma c chain complexes are detected in activated, but not in resting, T cells despite similar levels of gamma c chain expression, implying that the gamma c chain is not associated with the IL-7R in unstimulated T cells. Furthermore, IL-7R:gamma c chain association correlates with the expression of JAK-3 in T cells, but not in transfected COS-7 cells. The finding that IL-7R:gamma c chain assembly is controlled at a level beyond that of receptor expression has important implications for the control of cytokine function in T cells.
AU  - Page,TH
AU  - Lali,FV
AU  - Groome,N
AU  - Foxwell,BM
EP  - 5735
PY  - 1997///
SN  - 0022-1767
SP  - 5727
TI  - Association of the common gamma-chain with the human IL-7 receptor is modulated by T cell activation.
T2  - J Immunol
UR  - https://www.ncbi.nlm.nih.gov/pubmed/9190922
VL  - 158
ER  -
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