Imperial College London
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DrTheresaPage

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Research Fellow
 
 
 
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Contact

 

theresa.page Website

 
 
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Location

 

9N4Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Page:1995:10.1002/eji.1830251036,
author = {Page, TH and Lali, FV and Foxwell, BM},
doi = {10.1002/eji.1830251036},
journal = {Eur J Immunol},
pages = {2956--2960},
title = {Interleukin-7 activates p56lck and p59fyn, two tyrosine kinases associated with the p90 interleukin-7 receptor in primary human T cells.},
url = {http://dx.doi.org/10.1002/eji.1830251036},
volume = {25},
year = {1995}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We have investigated signaling events associated with the cloned 90-kDa (p90) interleukin-7 receptor (IL-7R) to determine whether changes in the signaling pathways initiated by this molecule can explain the ability of T cells to proliferate to IL-7 following activation. Using in vitro kinase assays we find that the p90 IL-7R in both unstimulated and activated human T cells is physically associated with two molecules with intrinsic kinase activity. Western blotting analysis reveals these proteins to be the src kinase enzymes, p59fyn and p56lck. Binding of human recombinant IL-7 to the p90 IL-7R results in increased activity of both receptor-associated kinases in both resting and activated mature T cells. Thus, the signaling pathways initiated via the p90 IL-7R-associated src kinases are unlikely to be solely responsible for the proliferation of only activated T cells in response to IL-7. Additional signals, which may derive from other IL-7R-associated molecules such as the gamma c, are clearly required for IL-7-driven proliferation of activated primary T cells.
AU  - Page,TH
AU  - Lali,FV
AU  - Foxwell,BM
DO  - 10.1002/eji.1830251036
EP  - 2960
PY  - 1995///
SN  - 0014-2980
SP  - 2956
TI  - Interleukin-7 activates p56lck and p59fyn, two tyrosine kinases associated with the p90 interleukin-7 receptor in primary human T cells.
T2  - Eur J Immunol
UR  - http://dx.doi.org/10.1002/eji.1830251036
UR  - https://www.ncbi.nlm.nih.gov/pubmed/7589097
VL  - 25
ER  -
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