Imperial College London
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DrTheresaPage

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Research Fellow
 
 
 
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Contact

 

theresa.page Website

 
 
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Location

 

9N4Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Crawley:1997:10.1074/jbc.272.23.15023,
author = {Crawley, JB and Rawlinson, L and Lali, FV and Page, TH and Saklatvala, J and Foxwell, BM},
doi = {10.1074/jbc.272.23.15023},
journal = {J Biol Chem},
pages = {15023--15027},
title = {T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation.},
url = {http://dx.doi.org/10.1074/jbc.272.23.15023},
volume = {272},
year = {1997}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Interleukin-2 (IL-2) is a potent T cell mitogen. However, the signaling pathways by which IL-2 mediates its mitogenic effect are not fully understood. One of the members of the mitogen-activated protein kinase (MAPK) family, p42/44MAPK (ERK2/1), is known to be activated by IL-2. We have now investigated the response to IL-2 of two other members of the MAP kinase family, p54MAP kinase (stress-activated protein kinase (SAPK)/Jun-N-terminal kinase (JNK)) and p38MAP kinase (p38/Mpk2/CSBP/RK), which respond primarily to stressful and inflammatory stimuli (e.g. tumor necrosis factor-alpha, IL-1, and lipopolysaccharide). Here we show that IL-2, and another T cell growth factor, IL-7, activate both SAPK/JNK and p38MAP kinase. Furthermore, inhibition of p38MAP kinase activity with a specific pyrinidyl imidazole inhibitor SB203580 that prevents activation of its downstream effector, MAPK-activating protein kinase-2, correlated with suppression of IL-2- and IL-7-driven T cell proliferation. These data indicate that in T cells p38MAP kinase has a role in transducing the mitogenic signal.
AU  - Crawley,JB
AU  - Rawlinson,L
AU  - Lali,FV
AU  - Page,TH
AU  - Saklatvala,J
AU  - Foxwell,BM
DO  - 10.1074/jbc.272.23.15023
EP  - 15027
PY  - 1997///
SN  - 0021-9258
SP  - 15023
TI  - T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation.
T2  - J Biol Chem
UR  - http://dx.doi.org/10.1074/jbc.272.23.15023
UR  - https://www.ncbi.nlm.nih.gov/pubmed/9169478
VL  - 272
ER  -
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