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@article{Willcocks:1993:10.1002/eji.1830230322,
author = {Willcocks, JL and Hales, A and Page, TH and Foxwell, BM},
doi = {10.1002/eji.1830230322},
journal = {Eur J Immunol},
pages = {716--720},
title = {The murine T cell line CT6 provides a novel bioassay for interleukin-7.},
url = {http://dx.doi.org/10.1002/eji.1830230322},
volume = {23},
year = {1993}
}

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TY  - JOUR
AB  - Like interleukin (IL)-2 and IL-4, IL-7 can act as a growth factor for activated T lymphocytes. Upon screening a panel of growth factor-dependent T cell lines, we found that only the cell line CT6 responded to IL-7, indeed as vigorously as to IL-2. Obviously, these findings challenge the validity of previous results on IL-2 production obtained using the CT6 cell line. However, they also demonstrate a novel and sensitive system for the bioassay of IL-7. The ability of the surveyed T cell lines to proliferate to IL-7 corresponded with the expression of IL-7 receptors (IL-7R) on the cell surface. The murine IL-7R on CT6 was shown to bind IL-7 with dual affinity and was visualized as an affinity cross-linked complex of 93 kDa. This IL-7R appears similar to that seen on murine splenic T cells and on 70Z/3, the pre-B cell line from which the murine IL-7R was cloned.
AU  - Willcocks,JL
AU  - Hales,A
AU  - Page,TH
AU  - Foxwell,BM
DO  - 10.1002/eji.1830230322
EP  - 720
PY  - 1993///
SN  - 0014-2980
SP  - 716
TI  - The murine T cell line CT6 provides a novel bioassay for interleukin-7.
T2  - Eur J Immunol
UR  - http://dx.doi.org/10.1002/eji.1830230322
UR  - https://www.ncbi.nlm.nih.gov/pubmed/8449219
VL  - 23
ER  -

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