Imperial College London
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ProfessorThomasChurcher

Faculty of Medicine, School of Public Health

Professor of Infectious Disease Dynamics
 
 
 
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Contact

 

thomas.churcher

 
 
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Location

 

G35Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gansané:2022:10.1186/s12936-021-04026-0,
author = {Gansané, A and Candrinho, B and Mbituyumuremyi, A and Uhomoibhi, P and NFalé, S and Mohammed, AB and Guelbeogo, WM and Sanou, A and Kangoye, D and Debe, S and Kagone, M and Hakizimana, E and Uwimana, A and Tuyishime, A and Ingabire, CM and Singirankabo, JH and Koenker, H and Marrenjo, D and Abilio, AP and Salvador, C and Savaio, B and Okoko, OO and Maikore, I and Obi, E and Awolola, ST and Adeogun, A and Babarinde, D and Ali, O and Guglielmo, F and Yukich, J and Scates, S and Sherrard-Smith, E and Churcher, T and Fornadel, C and Shannon, J and Kawakyu, N and Beylerian, E and Digre, P and Tynuv, K and Gogue, C and Mwesigwa, J and Wagman, J and Adeleke, M and Adeolu, AT and Robertson, M},
doi = {10.1186/s12936-021-04026-0},
journal = {Malaria Journal},
pages = {1--20},
title = {Design and methods for a quasi-experimental pilot study to evaluate the impact of dual active ingredient insecticide-treated nets on malaria burden in five regions in sub-Saharan Africa},
url = {http://dx.doi.org/10.1186/s12936-021-04026-0},
volume = {21},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundVector control tools have contributed significantly to a reduction in malaria burden since 2000, primarily through insecticidal-treated bed nets (ITNs) and indoor residual spraying. In the face of increasing insecticide resistance in key malaria vector species, global progress in malaria control has stalled. Innovative tools, such as dual active ingredient (dual-AI) ITNs that are effective at killing insecticide-resistant mosquitoes have recently been introduced. However, large-scale uptake has been slow for several reasons, including higher costs and limited evidence on their incremental effectiveness and cost-effectiveness. The present report describes the design of several observational studies aimed to determine the effectiveness and cost-effectiveness of dual-AI ITNs, compared to standard pyrethroid-only ITNs, at reducing malaria transmission across a variety of transmission settings.MethodsObservational pilot studies are ongoing in Burkina Faso, Mozambique, Nigeria, and Rwanda, leveraging dual-AI ITN rollouts nested within the 2019 and 2020 mass distribution campaigns in each country. Enhanced surveillance occurring in select study districts include annual cross-sectional surveys during peak transmission seasons, monthly entomological surveillance, passive case detection using routine health facility surveillance systems, and studies on human behaviour and ITN use patterns. Data will compare changes in malaria transmission and disease burden in districts receiving dual-AI ITNs to similar districts receiving standard pyrethroid-only ITNs over three years. The costs of net distribution will be calculated using the provider perspective including financial and economic costs, and a cost-effectiveness analysis will assess incremental cost-effectiveness ratios for Interceptor® G2, Royal Guard®, and piperonyl butoxide ITNs in comparison to standard pyrethroid-only ITNs, based on incidence rate ratios calculated from routine data.ConclusionsEvidence
AU  - Gansané,A
AU  - Candrinho,B
AU  - Mbituyumuremyi,A
AU  - Uhomoibhi,P
AU  - NFalé,S
AU  - Mohammed,AB
AU  - Guelbeogo,WM
AU  - Sanou,A
AU  - Kangoye,D
AU  - Debe,S
AU  - Kagone,M
AU  - Hakizimana,E
AU  - Uwimana,A
AU  - Tuyishime,A
AU  - Ingabire,CM
AU  - Singirankabo,JH
AU  - Koenker,H
AU  - Marrenjo,D
AU  - Abilio,AP
AU  - Salvador,C
AU  - Savaio,B
AU  - Okoko,OO
AU  - Maikore,I
AU  - Obi,E
AU  - Awolola,ST
AU  - Adeogun,A
AU  - Babarinde,D
AU  - Ali,O
AU  - Guglielmo,F
AU  - Yukich,J
AU  - Scates,S
AU  - Sherrard-Smith,E
AU  - Churcher,T
AU  - Fornadel,C
AU  - Shannon,J
AU  - Kawakyu,N
AU  - Beylerian,E
AU  - Digre,P
AU  - Tynuv,K
AU  - Gogue,C
AU  - Mwesigwa,J
AU  - Wagman,J
AU  - Adeleke,M
AU  - Adeolu,AT
AU  - Robertson,M
DO  - 10.1186/s12936-021-04026-0
EP  - 20
PY  - 2022///
SN  - 1475-2875
SP  - 1
TI  - Design and methods for a quasi-experimental pilot study to evaluate the impact of dual active ingredient insecticide-treated nets on malaria burden in five regions in sub-Saharan Africa
T2  - Malaria Journal
UR  - http://dx.doi.org/10.1186/s12936-021-04026-0
UR  - https://malariajournal.biomedcentral.com/articles/10.1186/s12936-021-04026-0
UR  - http://hdl.handle.net/10044/1/93866
VL  - 21
ER  -
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