Imperial College London
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ProfessorThomasChurcher

Faculty of Medicine, School of Public Health

Professor of Infectious Disease Dynamics
 
 
 
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Contact

 

thomas.churcher

 
 
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Location

 

G35Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Martin:2022:10.1186/s12936-022-04119-4,
author = {Martin, JL and Messenger, LA and Mosha, FW and Lukole, E and Mosha, JF and Kulkarni, M and Churcher, TS and Sherrard-Smith, E and Manjurano, A and Protopopoff, N and Rowland, M},
doi = {10.1186/s12936-022-04119-4},
journal = {Malaria Journal},
pages = {96--96},
title = {Durability of three types of dual active ingredient long-lasting insecticidal net compared to a pyrethroid-only LLIN in Tanzania: methodology for a prospective cohort study nested in a cluster randomized controlled trial.},
url = {http://dx.doi.org/10.1186/s12936-022-04119-4},
volume = {21},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Progress achieved by long-lasting insecticidal nets (LLINs) against malaria is threatened by widespread selection of pyrethroid resistance among vector populations. LLINs with non-pyrethroid insecticides are urgently needed. This study aims to assess the insecticide and textile durability of three classes of dual-active ingredient (A.I.) LLINs using techniques derived from established WHO LLIN testing methods to set new standards of evaluation. METHODS: A WHO Phase 3 active ingredients and textile durability study will be carried out within a cluster randomized controlled trial in 40 clusters in Misungwi district, Tanzania. The following treatments will be evaluated: (1) Interceptor®G2 combining chlorfenapyr and the pyrethroid alpha-cypermethrin, (2) Royal Guard® treated with pyriproxyfen and alpha-cypermethrin, (3) Olyset™ Plus which incorporates a synergist piperonyl butoxide and the pyrethroid permethrin, and (4) a reference standard alpha-cypermethrin only LLIN (Interceptor®). 750 nets will be followed in 5 clusters per intervention arm at 6, 12, 24 and 36 months post distribution for survivorship and hole index assessment. A second cohort of 1950 nets per net type will be identified in 10 clusters, of which 30 LLINs will be withdrawn for bio-efficacy and chemical analysis every 6 months up to 36 months and another 30 collected for experimental hut trials every year. Bio-efficacy will be assessed using cone bioassays and tunnel tests against susceptible and resistant laboratory strains of Anopheles gambiae sensu stricto. Efficacy of field-collected nets will be compared in six experimental huts. The main outcomes will be Anopheles mortality up to 72 h post exposure, blood feeding and egg maturation using ovary dissection to assess impact on fecundity. CONCLUSIONS: Study findings will help develop bio-efficacy and physical durability criteria for partner A.I., in relation to the cRCT epidemiological and entomologi
AU  - Martin,JL
AU  - Messenger,LA
AU  - Mosha,FW
AU  - Lukole,E
AU  - Mosha,JF
AU  - Kulkarni,M
AU  - Churcher,TS
AU  - Sherrard-Smith,E
AU  - Manjurano,A
AU  - Protopopoff,N
AU  - Rowland,M
DO  - 10.1186/s12936-022-04119-4
EP  - 96
PY  - 2022///
SN  - 1475-2875
SP  - 96
TI  - Durability of three types of dual active ingredient long-lasting insecticidal net compared to a pyrethroid-only LLIN in Tanzania: methodology for a prospective cohort study nested in a cluster randomized controlled trial.
T2  - Malaria Journal
UR  - http://dx.doi.org/10.1186/s12936-022-04119-4
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35305667
UR  - https://malariajournal.biomedcentral.com/articles/10.1186/s12936-022-04119-4#Fun
UR  - http://hdl.handle.net/10044/1/96014
VL  - 21
ER  -
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