Environmentally exposed surfaces in humans are colonized by a vast number of foreign microbes (the commensal microbiota) and these organisms play a key role in regulating mucosal and systemic immune function. Disruption of this relationship is linked to a wide variety of diseases and immune dysfunctions, including chronic inflammatory conditions at the mucosa, autoimmunity and increased susceptibility to infection by bacteria, viruses and parasites. There remains, however, a major gap in understanding the mechanistic basis for the influence of the commensal microbiota on immune function, especially systemic immunity. The broad theme of my research, therefore, is to understand how programming of innate immunity by the microbiota influences host responses to bacterial infection and vaccination, and how changes to the composition of the microbiota disrupts these responses.
et al., 2023, Symbiotic Firmicutes establish mutualism with the host via innate tolerance and resistance to control systemic immunity., Cell Host Microbe, Vol:31, Pages:1433-1449.e9
et al., 2023, Antibiotics promote intestinal growth of carbapenem-resistant Enterobacteriaceae by enriching nutrients and depleting microbial metabolites, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-20
et al., 2022, Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease., Journal of Clinical Investigation, Vol:132, ISSN:0021-9738, Pages:1-16
Panwar RB, Sequeira RP, Clarke TB, 2021, Microbiota-mediated protection against antibiotic-resistant pathogens, Genes and Immunity, Vol:22, ISSN:1466-4879, Pages:255-267
et al., 2021, Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane, Elife, Vol:10, ISSN:2050-084X, Pages:1-26