Imperial College London
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DrTimothyDawes

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 3298tim.dawes Website

 
 
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Location

 

MRC London Institute of Medical Sciences, 111 ISDRobert Steiner MR unitHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2015:10.1016/j.jcmg.2015.08.007,
author = {de, Marvao A and Dawes, TJW and Shi, W and Durighel, G and Rueckert, D and Cook, SA and O'Regan, DP},
doi = {10.1016/j.jcmg.2015.08.007},
journal = {JACC: Cardiovascular Imaging},
pages = {1260--1269},
title = {Precursors of the hypertensive heart phenotype develop in normotensive adults: a high resolution 3D MRI study},
url = {http://dx.doi.org/10.1016/j.jcmg.2015.08.007},
volume = {8},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesThis study used high-resolution 3-dimensional cardiac magnetic resonance to define the anatomical and functional left ventricular (LV) properties associated with increasing systolic blood pressure (SBP) in a drug-naïve cohort.BackgroundLV hypertrophy and remodeling occur in response to hemodynamic stress but little is known about how these phenotypic changes are initiated in the general population.MethodsIn this study, 1,258 volunteers (54% women, mean age 40.6 ± 12.8 years) without self-reported cardiovascular disease underwent 3-dimensional cardiac magnetic resonance combined with computational modeling. The relationship between SBP and wall thickness (WT), relative WT, end-systolic wall stress (WS), and fractional wall thickening were analyzed using 3-dimensional regression models adjusted for body surface area, sex, race, age, and multiple testing. Significantly associated points in the LV model (p < 0.05) were identified and the relationship with SBP reported as mean β coefficients.ResultsThere was a continuous relationship between SBP and asymmetric concentric hypertrophic adaptation of the septum and anterior wall that was associated with normalization of wall stress. In the lateral wall an increase in wall stress with rising SBP was not balanced by a commensurate hypertrophic relationship. In normotensives, SBP was positively associated with WT (β = 0.09) and relative WT (β = 0.07) in the septal and anterior walls, and this regional hypertrophic relationship was progressively stronger among pre-hypertensives (β = 0.10) and hypertensives (β = 0.30).ConclusionsThese findings show that the precursors of the hypertensive heart phenotype can be traced to healthy normotensive adults and that an independent and continuous relationship exists between adverse LV remodeling and SBP in a low-risk population. These adaptations show distinct regional variations with concentric hypertrophy of the septum and eccentric hyper
AU  - de,Marvao A
AU  - Dawes,TJW
AU  - Shi,W
AU  - Durighel,G
AU  - Rueckert,D
AU  - Cook,SA
AU  - O'Regan,DP
DO  - 10.1016/j.jcmg.2015.08.007
EP  - 1269
PY  - 2015///
SN  - 1936-878X
SP  - 1260
TI  - Precursors of the hypertensive heart phenotype develop in normotensive adults: a high resolution 3D MRI study
T2  - JACC: Cardiovascular Imaging
UR  - http://dx.doi.org/10.1016/j.jcmg.2015.08.007
UR  - http://hdl.handle.net/10044/1/26025
VL  - 8
ER  -
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