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@article{Dawes:2016:10.1148/radiol.2016151527,
author = {Dawes, TJW and Gandhi, A and de, Marvao A and Buzaco, R and Tokarczuk, P and Quinlan, M and Durighel, G and Diamond, T and Monje, Garcia L and de, Cesare A and Cook, SA and O'Regan, DP},
doi = {10.1148/radiol.2016151527},
journal = {Radiology},
title = {Pulmonary artery stiffness is independently associated with right ventricular mass and function: a cardiac magnetic resonance study.},
url = {http://dx.doi.org/10.1148/radiol.2016151527},
volume = {280},
year = {2016}
}

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TY  - JOUR
AB  - PurposeTo determine the relationship between pulmonary artery (PA) stiffness and both right ventricular (RV) mass and function with cardiac magnetic resonance (MR) imaging.Materials and MethodsThe study was approved by the local research ethics committee, and all participants gave written informed consent. Cardiac MR imaging was performed at 1.5 T in 156 healthy volunteers (63% women; age range, 19–61 years; mean age, 36.1 years). High-temporal-resolution phase-contrast imaging was performed in the main and right PAs. Pulmonary pulse wave velocity (PWV) was determined by the interval between arterial systolic upslopes. RV function was assessed with feature tracking to derive peak systolic strain and strain rate, as well as peak early-diastolic strain rate. RV volumes, ejection fraction (RVEF), and mass were measured from the cine images. The association of pulmonary PWV with RV function and mass was quantified with univariate linear regression. Interstudy repeatability was assessed with intraclass correlation.ResultsThe repeatability coefficient for pulmonary PWV was 0.96. Increases in pulmonary PWV and RVEF were associated with increases in age (r = 0.32, P < .001 and r = 0.18, P = .025, respectively). After adjusting for age (P = .090), body surface area (P = .073), and sex (P = .005), pulmonary PWV demonstrated an independent positive association with RVEF (r = 0.34, P = .026). Significant associations were also seen with RV mass (r = 0.41, P = .004), RV radial strain (r = 0.38, P = .022), and strain rate (r = 0.35, P = .002), and independent negative associations were seen with radial (r = 0.27, P = .003), longitudinal (r = 0.40, P = .007), and circumferential (r = 0.31, P = .005) peak early-diastolic strain rate with the same covariates.ConclusionPulmonary PWV is reliably assessed with cardiac MR imaging. In subjects with no known cardiovascular disease, increasing PA stiffness is associated with increasing age and is also moderately associated with bo
AU  - Dawes,TJW
AU  - Gandhi,A
AU  - de,Marvao A
AU  - Buzaco,R
AU  - Tokarczuk,P
AU  - Quinlan,M
AU  - Durighel,G
AU  - Diamond,T
AU  - Monje,Garcia L
AU  - de,Cesare A
AU  - Cook,SA
AU  - O'Regan,DP
DO  - 10.1148/radiol.2016151527
PY  - 2016///
SN  - 1527-1315
TI  - Pulmonary artery stiffness is independently associated with right ventricular mass and function: a cardiac magnetic resonance study.
T2  - Radiology
UR  - http://dx.doi.org/10.1148/radiol.2016151527
UR  - http://hdl.handle.net/10044/1/29835
VL  - 280
ER  -

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