Imperial College London
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DrTimothyDawes

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 3298tim.dawes Website

 
 
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Location

 

MRC London Institute of Medical Sciences, 111 ISDRobert Steiner MR unitHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Corden:2016:10.1186/s12968-016-0251-4,
author = {Corden, B and de, Marvao A and Dawes, T and Shi, W and Rueckert, D and Cook, S and O'Regan, DP},
doi = {10.1186/s12968-016-0251-4},
journal = {Journal of Cardiovascular Magnetic Resonance},
title = {Relationship between body composition and left ventricular geometry using three dimensional cardiovascular magnetic resonance},
url = {http://dx.doi.org/10.1186/s12968-016-0251-4},
volume = {18},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundAlthough obesity is associated with alterations in left ventricular (LV) mass and volume which are of prognostic significance, widely differing patterns of remodelling have been attributed to adiposity. Our aim was to define the relationship between body composition and LV geometry using three-dimensional cardiovascular magnetic resonance.MethodsIn an observational study 1530 volunteers (55 % female, mean age 41.3 years) without known cardiovascular disease underwent investigation including breath-hold high spatial resolution 3D cines. Atlas-based segmentation and co-registration was used to create a statistical model of wall thickness (WT) and relative wall thickness (RWT) throughout the LV. The relationship between bio-impedence body composition and LV geometry was assessed using 3D regression models adjusted for age, systolic blood pressure (BP), gender, race and height, with correction to control the false discovery rate.ResultsLV mass was positively associated with fat mass in women but not in men (LV mass: women β = 0.11, p < 0.0001; men β = −0.01, p = 0.82). The 3D models revealed that in males fat mass was strongly associated with a concentric increase in relative wall thickness (RWT) throughout most of the LV (β = 0.37, significant area = 96 %) and a reduced mid-ventricular cavity (β = −0.22, significant area = 91 %). In women the regional concentric hypertrophic association was weaker, and the basal lateral wall showed an inverse relationship between RWT and fat mass (β = −0.11, significant area = 4.8 %).ConclusionsIn an adult population without known cardiovascular disease increasing body fat is predominately associated with asymmetric concentric hypertrophy independent of systolic BP, with women demonstrating greater cavity dilatation than men. Conventional mass
AU  - Corden,B
AU  - de,Marvao A
AU  - Dawes,T
AU  - Shi,W
AU  - Rueckert,D
AU  - Cook,S
AU  - O'Regan,DP
DO  - 10.1186/s12968-016-0251-4
PY  - 2016///
SN  - 1532-429X
TI  - Relationship between body composition and left ventricular geometry using three dimensional cardiovascular magnetic resonance
T2  - Journal of Cardiovascular Magnetic Resonance
UR  - http://dx.doi.org/10.1186/s12968-016-0251-4
UR  - http://hdl.handle.net/10044/1/32689
VL  - 18
ER  -
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